{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:34:10Z","timestamp":1766086450285,"version":"3.48.0"},"reference-count":23,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>Ten patients with ampullary carcinoma, not suitable for surgery, were treated with endoscopic photodynamic therapy (PDT) to evaluate the feasibility and safety of treatment. Patients received 4 mg kg-1 of haematoporphyrin derivative intravenously. Two days later, a duodenoscopy was performed and red (630 nm) light delivered to the tumour at fixed energy densities of 50 J or 200 J cm-1 per application, depending on the type of optical fibre used. The tumours were treated by three or four light applications at each session. Treatment was repeated up to five times at intervals of three to six months. The sole complication of PDT was moderate skin photosensitivity, which occurred in three patients. Tumour size was assessed at four to eight weekly intervals. In the absence of macroscopic tumour, biopsy specimens were taken. In three patients with small tumours confined to the ampulla, remission was obtained for periods ranging from eight to 12 months. In a further four patients with small tumours bulk was greatly reduced. There was little response in three patients with extensive duodenal involvement. Therefore PDT for ampullary carcinoma is both feasible and safe, and with refinement may prove curative for small tumours.<\/jats:p>","DOI":"10.1136\/gut.36.6.853","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"853-856","source":"Crossref","is-referenced-by-count":47,"title":["Photodynamic therapy for malignant tumours of the ampulla of Vater."],"prefix":"10.1136","volume":"36","author":[{"given":"A M","family":"Abulafi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J T","family":"Allardice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N S","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"van Someren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C P","family":"Swain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ainley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"ref_1","first-page":"297","article-title":"Carcinoma of the ampulla of Vater","volume":"156","author":"Barton, R.M.; Copeland, E.M.","year":"1983","unstructured":"Barton RM, Copeland EM. Carcinoma of the ampulla of Vater. Surg Gynecol Obstet 1983; 156: 297-301.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0002-9610(89)90201-8","article-title":"Significance of tumour spread in adenocarcinoma of the ampulla of Vater","volume":"158","author":"Delcore, M.; Connor, C.S.; Thomas, J.H.; Friesen, SR, Hermreck; A.S.","year":"1989","unstructured":"Delcore M, Connor CS, Thomas JH, Friesen SR, Hermreck AS. Significance of tumour spread in adenocarcinoma of the ampulla of Vater. AmJ Surg 1989; 158: 593-6.","journal-title":"AmJ Surg"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/00000658-193510000-00023","article-title":"Treatment of carcinoma of the ampulla of Vater","volume":"102","author":"Whipple, A.O.; Parsons, W.B.; Mullins, C.R.","year":"1935","unstructured":"Whipple AO, Parsons WB, Mullins CR. Treatment of carcinoma of the ampulla of Vater. Ann Surg 1935; 102: 763-79.","journal-title":"Ann Surg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0002-9610(85)80008-8","article-title":"Periampullary tumours: which ones should be resected?","volume":"149","author":"Jones, B.A.; Langer, B.; Girotti, M.","year":"1985","unstructured":"Jones BA, Langer B, Girotti M. Periampullary tumours: which ones should be resected? Am Jf Surg 1985; 149: 46-51.","journal-title":"Am Jf Surg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0002-9610(86)90024-3","article-title":"Decreased morbidity and mortality after pancreaticoduodenectomy","volume":"151","author":"Grace, P.A.; Pitt, H.A.; Tomkins, R.K.; DenBester, L.; Longmire, W.P.","year":"1986","unstructured":"Grace PA, Pitt HA, Tomkins RK, DenBester L, Longmire WP. Decreased morbidity and mortality after pancreaticoduodenectomy Am J Surg 1986; 151: 141-9.","journal-title":"Am J Surg"},{"key":"ref_6","first-page":"716","article-title":"Results of surgical treatment of periampullary turnours: a thirty-five year experience","volume":"100","author":"Tarazi, R.Y.; Hermann, R.E.; Vogt, D.P.; Hoerr, S.O.; CB, Jr, Esselstyn; Cooperman, A.M.","year":"1986","unstructured":"Tarazi RY, Hermann RE, Vogt DP, Hoerr SO, Esselstyn CB Jr, Cooperman AM, et al. Results of surgical treatment of periampullary turnours: a thirty-five year experience. Surgery 1986; 100: 716-23.","journal-title":"Surgery"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/bjs.1800741025","article-title":"Treatment and outcome in 52 consecutive cases of ampullary carcinoma","volume":"74","author":"Neoptolemos, J.P.; Talbot, I.C.; Carr-Locke, D.L.; Shaw, D.E.; Cockleburgh, R.; Hall, A.W.","year":"1987","unstructured":"Neoptolemos JP, Talbot IC, Carr-Locke DL, Shaw DE, Cockleburgh R, Hall AW, et al. Treatment and outcome in 52 consecutive cases of ampullary carcinoma. BrJ Surg 1987; 74: 957-61.","journal-title":"BrJ Surg"},{"key":"ref_8","first-page":"544","article-title":"Experience with 647 consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct","volume":"210","author":"Michelassi, F.; Erroi, F.; Dawson, P.J.; Pietrabissa, A.; Noda, S.; Handcock, M.","year":"1989","unstructured":"Michelassi F, Erroi F, Dawson PJ, Pietrabissa A, Noda S, Handcock M, et al. Experience with 647 consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct. Ann Surg 1989; 210: 544-54."},{"key":"ref_9","first-page":"353","article-title":"Radical resection for carcinoma of the ampulla of Vater","volume":"126","author":"Monson, J.R.T.; Donohue, J.H.; McEntee, G.P.; McIlrath, D.C.; van Heerden, J.A.; Shorter, R.G.","year":"1990","unstructured":"Monson JRT, Donohue JH, McEntee GP, McIlrath DC, van Heerden JA, Shorter RG, et al. Radical resection for carcinoma of the ampulla of Vater. Arch Surg 1990; 126: 353-7.","journal-title":"Arch Surg"},{"key":"ref_10","first-page":"1169","article-title":"Wide local excision as an alternative treatment for periampullary carcinoma","volume":"82","year":"1987","unstructured":"Goldberg M, Zamir 0, Hadary A. Wide local excision as an alternative treatment for periampullary carcinoma. AmJ Gastroenterol 1987; 82: 1169-71.","journal-title":"AmJ Gastroenterol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/archsurg.1991.01410290128026","article-title":"Indications for and the technique of local resection of tumors of the papilla of Vater","volume":"126","author":"Farouk, M.; Niotis, M.; Branum, G.D.; Cotton, P.B.; Meyers, W.C.","year":"1991","unstructured":"Farouk M, Niotis M, Branum GD, Cotton PB, Meyers WC. Indications for and the technique of local resection of tumors of the papilla of Vater. Arch Surg 1991; 126: 650-2.","journal-title":"Arch Surg"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/1097-0142(19890701)64:1<161::AID-CNCR2820640127>3.0.CO;2-D","article-title":"Contribution of endoscopy to diagnosis and treatment of tumors of the ampulla of Vater","volume":"64","author":"Ponchon, T.; Berger, F.; Chavaillon, A.; Bory, R.; Lambert, R.","year":"1989","unstructured":"Ponchon T, Berger F, Chavaillon A, Bory R, Lambert R. Contribution of endoscopy to diagnosis and treatment of tumors of the ampulla of Vater. Cancer 1989; 64: 161-7.","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00000658-196806000-00002","article-title":"Haematoporphyrin-derived fluorescence in malignant neoplasms","volume":"167","author":"Gregorie, H.B.; Horger, E.O.; Ward, J.L.; Green, J.F.; Richards, T.; Robertson, H.C.","year":"1968","unstructured":"Gregorie HB, Horger EO, Ward JL, Green JF, Richards T, Robertson HC, et al. Haematoporphyrin-derived fluorescence in malignant neoplasms. Ann Surg 1968; 167: 820-8.","journal-title":"Ann Surg"},{"key":"ref_14","first-page":"83","article-title":"Photoradiation therapy (PRT) of malignant tumours","volume":"2","author":"Dougherty, T.J.","year":"1984","unstructured":"Dougherty TJ. Photoradiation therapy (PRT) of malignant tumours. CRC Crit Rev 1984; 2: 83-116.","journal-title":"CRC Crit Rev"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1751-1097.1987.tb04850.x","article-title":"The contrasting mechanisms of colonic damage between photodynamic therapy and thermal injury","volume":"46","author":"Barr, H.; Tralau, C.J.; Boulos, P.B.; MacRobert, A.J.; Tilly, R.; Bown, S.G.","year":"1987","unstructured":"Barr H, Tralau CJ, Boulos PB, MacRobert AJ, Tilly R, Bown SG. The contrasting mechanisms of colonic damage between photodynamic therapy and thermal injury. Photochem Photobiol 1987; 46: 795-800.","journal-title":"Photochem Photobiol"},{"issue":"26","key":"ref_16","first-page":"1","article-title":"The use of a derivative of haematoporphyrin in tumour detection","volume":"1961","author":"Lipson, R.L.; Baldes, E.J.; Olsen, A.M.","unstructured":"Lipson RL, Baldes EJ, Olsen AM. The use of a derivative of haematoporphyrin in tumour detection. Jf Natd Cancer Inst 1961; 26: 1-11.","journal-title":"Jf Natd Cancer Inst"},{"key":"ref_17","first-page":"146","article-title":"Determination of 3H and 14C HpD distribution in malignant and normal tissue","volume":"39","author":"Gomer, C.J.; Dougherty, T.J.","year":"1979","unstructured":"Gomer CJ, Dougherty TJ. Determination of 3H and 14C HpD distribution in malignant and normal tissue. Cancer Res 1979; 39: 146-51.","journal-title":"Cancer Res"},{"key":"ref_18","first-page":"3053","article-title":"Biological and biophysical properties of the tumor-localising component of haematoporphyrin derivative","volume":"45","author":"Kessel, D.; Cheng, M.","year":"1985","unstructured":"Kessel D, Cheng M. Biological and biophysical properties of the tumor-localising component of haematoporphyrin derivative. Cancer Res 1985; 45: 3053-7.","journal-title":"Cancer Res"},{"issue":"47","key":"ref_19","first-page":"2042","article-title":"Theraputischen Versuche mit fluorescierenden Stoffen","volume":"1903","author":"H, Von Tappeiner; A, Jesionek","unstructured":"Von Tappeiner H, Jesionek A. Theraputischen Versuche mit fluorescierenden Stoffen. Munchener Medizinische Wochenschrift 1903; 47: 2042-4.","journal-title":"Munchener Medizinische Wochenschrift"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0016-5085(92)91800-J","article-title":"Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography","volume":"102","author":"Rosch, T.; Braig, C.; Gain, T.; Feuerbach, S.; Rudiger Siewert, J.","year":"1992","unstructured":"Rosch T, Braig C, Gain T, Feuerbach S, Rudiger Siewert J, et al. Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography. Gastroenterology 1992; 102: 188-99.","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/bjc.1991.474","article-title":"Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results","volume":"64","author":"Ris, H.B.; Altermat, H.J.; Inderbitzi, R.; Hess, R.; Nachbur, B.; Stewart, J.C.M.","year":"1991","unstructured":"Ris HB, Altermat HJ, Inderbitzi R, Hess R, Nachbur B, Stewart JCM, et al. Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. BrJ Cancer 1991; 64: 1116-20.","journal-title":"BrJ Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/bjc.1991.473","article-title":"Distribution and photodynamic effect of disulphonated aluminium phthalocyanine in the pancreas and adjacent tissues in the Syrian golden hamster","volume":"64","author":"Nuutinen, P.J.O.; Chatiani, P.T.; Bedwell, J.; MacRobert, A.J.; Philips, D.; Bown, S.G.","year":"1991","unstructured":"Nuutinen PJO, Chatiani PT, Bedwell J, MacRobert AJ, Philips D, Bown SG. Distribution and photodynamic effect of disulphonated aluminium phthalocyanine in the pancreas and adjacent tissues in the Syrian golden hamster. BrJ Cancer 1991; 64: 1108-15.","journal-title":"BrJ Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1001\/archsurg.1991.01410250119022","article-title":"Photodynamic therapy to treat tumors of the extrahepatic bile ducts","volume":"126","author":"McCaughan, J.S.; Mertens, B.F.; Cho, C.; Barabash, R.D.; Payton, H.W.","year":"1991","unstructured":"McCaughan JS, Mertens BF, Cho C, Barabash RD, Payton HW. Photodynamic therapy to treat tumors of the extrahepatic bile ducts. Arch Surg 1991; 126: 111-3.","journal-title":"Arch Surg"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.36.6.853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:38:37Z","timestamp":1765651117000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.36.6.853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1995,6,1]]},"published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1136\/gut.36.6.853"],"URL":"https:\/\/doi.org\/10.1136\/gut.36.6.853","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}