{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:15:37Z","timestamp":1770822937973,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>Cytomegalovirus (CMV) colitis may cause symptoms and signs identical to those of idiopathic inflammatory bowel disease. Although difficult to diagnose with certainty, the histological finding of cytomegalovirus inclusions in tissue from a case of suspected inflammatory bowel disease is strongly suggestive. CMV colitis is an entity almost entirely confined to cases of severe immunosuppression. The case of a 79 year old widower who was admitted to hospital with symptoms suggestive of inflammatory bowel disease is presented. Despite medical treatment his condition worsened and he developed toxic dilatation of the colon requiring colectomy. Histological examination showed a mild superficial pancolitis, with focal severe inflammation, deep fissuring ulceration, and pseudopolyposis. Abundant CMV inclusions were seen in cells associated with the ulcerating inflammatory tissue. A diagnosis of indeterminate colitis with CMV was made. The patient's condition worsened after surgery and he died a few days later despite intensive treatment, including antiviral chemotherapy directed against CMV. After death HIV serology was found to be positive. Regardless of the age and perceived lifestyle of the patient, a diagnosis of CMV colitis in someone not known to be immunosuppressed raises the possibility of HIV infection.<\/jats:p>","DOI":"10.1136\/gut.37.1.148","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"148-150","source":"Crossref","is-referenced-by-count":24,"title":["HIV associated cytomegalovirus colitis as a mimic of inflammatory bowel disease."],"prefix":"10.1136","volume":"37","author":[{"given":"D E","family":"Roskell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Hyde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1136\/gut.27.12.1419","article-title":"Incidence and clinical significance of colonic cytomegalovirus infection in idiopathic inflammatory bowel disease requiring colectomy","volume":"27","author":"Eyre-Brook, I.A.; Dundas, S.","year":"1986","unstructured":"Eyre-Brook IA, Dundas S. Incidence and clinical significance of colonic cytomegalovirus infection in idiopathic inflammatory bowel disease requiring colectomy. Gut 1986; 27: 1419-25.","journal-title":"Gut"},{"key":"ref_2","first-page":"355","article-title":"Cytomegalovirus infections of the colon: a possible role in exacerbations of Roskell, Hyde, Campbell, J7ewell, Gray inflammatory bowel disease","volume":"80","author":"Berk, T.; Gordon, S.J.; Choi, H.Y.; Cooper, H.S.","year":"1985","unstructured":"Berk T, Gordon SJ, Choi HY, Cooper HS. Cytomegalovirus infections of the colon: a possible role in exacerbations of Roskell, Hyde, Campbell, J7ewell, Gray inflammatory bowel disease. Am J Gastroenterol 1985; 80: 355-60.","journal-title":"Am J Gastroenterol"},{"key":"ref_3","first-page":"794","article-title":"Toxic megacolon in cytomegalovirus colitis","volume":"84","author":"Orloff, J.J.; Saito, R.; Lasky, S.; Dave, H.","year":"1989","unstructured":"Orloff JJ, Saito R, Lasky S, Dave H. Toxic megacolon in cytomegalovirus colitis. Am J Gastroenterol 1989; 84: 794-7.","journal-title":"Am J Gastroenterol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jmv.1890380306","article-title":"Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction","volume":"38","author":"Wakefield, A.J.; Fox, J.D.; Sawyerr, A.M.; Taylor, J.E.; Sweenie, C.H.; Smith, A.D.","year":"1992","unstructured":"Wakefield AJ, Fox JD, Sawyerr AM, Taylor JE, Sweenie CH, Smith AD, et al. Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction. J Med Virol 1992; 38: 183-90.","journal-title":"J Med Virol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/BF01540440","article-title":"Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome","volume":"33","author":"Rene, E.; Marche, C.; Chevalier, T.; Rouzioux, C.; Reignier, B.; Saimot, A.G.","year":"1988","unstructured":"Rene E, Marche C, Chevalier T, Rouzioux C, Reignier B, Saimot AG, et al. Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome. Dig Dis Sci 1988; 33: 741-50.","journal-title":"Dig Dis Sci"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/00313028909061066","article-title":"Cytomegalovirus vasculitis and colon perforation in a patient with the acquired immunodeficiency syndrome","volume":"21","author":"Tatum, E.T.; Sun, P.C.; Cohn, D.L.","year":"1989","unstructured":"Tatum ET, Sun PC, Cohn DL. Cytomegalovirus vasculitis and colon perforation in a patient with the acquired immunodeficiency syndrome. Pathology 1989; 21: 235-8.","journal-title":"Pathology"},{"issue":"1","key":"ref_7","first-page":"29","article-title":"Cytomegalovirus colitis in AIDS: presentation in 44 patients and a review of the literature","volume":"4","author":"Dieterich, D.T.; Rahmin, M.","year":"1991","unstructured":"Dieterich DT, Rahmin M. Cytomegalovirus colitis in AIDS: presentation in 44 patients and a review of the literature. Journal of Acquired Immune Deficiency Syndrome 1991; 4 (suppl 1): S29-35.","journal-title":"Journal of Acquired Immune Deficiency Syndrome"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/BF02139220","article-title":"Intestinal perforation due to cytomegalovirus infection in patients with AIDS","volume":"33","author":"Kram, H.B.; Schoemaker, W.C.","year":"1990","unstructured":"Kram HB, Schoemaker WC. Intestinal perforation due to cytomegalovirus infection in patients with AIDS. Dis Colon Rectum 1990; 33: 1037-40.","journal-title":"Dis Colon Rectum"},{"key":"ref_9","first-page":"67","article-title":"The pathology of AIDS: an update","volume-title":"Recent advances in histopathology. Vol 15","author":"Millard, P.R.; Esiri, M.M.","year":"1992","unstructured":"Millard PR, Esiri MM. The pathology of AIDS: an update. In: Anthony PP, Macsween RNM, eds. Recent advances in histopathology. Vol 15. Edinburgh: Churchill Livingstone, 1992: 67-92."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.37.1.148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:29:07Z","timestamp":1765618147000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.37.1.148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1995,7,1]]},"published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1136\/gut.37.1.148"],"URL":"https:\/\/doi.org\/10.1136\/gut.37.1.148","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}