{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:40:35Z","timestamp":1787319635302,"version":"build-2736575974"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>Omeprazole plus amoxicillin cures Helicobacter pylori infection. The hypothesis was tested that low acidity is a predictor of outcome. Fifty patients with relapsing or complicated, or both H pylori positive duodenal (n = 25) or gastric ulcer (n = 25) were randomly treated with either omeprazole 20 mg twice daily plus amoxicillin 1 g twice daily or with omeprazole 40 mg twice daily plus amoxicillin 1 g twice daily over two weeks. After one week of combined treatment, a 24 hour gastric pH measurement was performed in all patients. H pylori cure rate was 67%. Patients who later turned out to be cured had higher pH values during night time and after meals (p &lt; 0.05). In an explorative analysis drug compliance, smoking, location of the ulcer (duodenum versus stomach), age, and grade of body gastritis were additional predictors of the outcome. Smoking (p = 0.006), compliance (p = 0.037), duodenal ulcer disease (p = 0.065), and young age (p = 0.021) were related to high acidity. In conclusion, the success of eradication treatment with omeprazole and amoxicillin in ulcer patients infected with H pylori depends on intragastric pH. Drug compliance, smoking habits, location of ulcer, age, and activity of body gastritis are other predictors and in part related to intragastric acidity.<\/jats:p>","DOI":"10.1136\/gut.37.1.39","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"39-43","source":"Crossref","is-referenced-by-count":89,"title":["Intragastric acidity as a predictor of the success of Helicobacter pylori eradication: a study in peptic ulcer patients with omeprazole and amoxicillin."],"prefix":"10.1136","volume":"37","author":[{"given":"J","family":"Labenz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Blum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Jorias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Leverkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sollb\u00f6hmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bertrams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"B\u00f6rsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"ref_1","first-page":"697","article-title":"High dose omeprazole treatment combined with amoxicillin eradicates Helicobacter pylori","volume-title":"European Journal of Gastroenterology and Hepatology 1992; 4","author":"Bayerdorffer, E.; Mannes, G.A.; Sommer, A.; Hochter, W.; Weingart, J.; Hatz, R.","unstructured":"Bayerdorffer E, Mannes GA, Sommer A, Hochter W, Weingart J, Hatz R, et al. High dose omeprazole treatment combined with amoxicillin eradicates Helicobacter pylori. European Journal of Gastroenterology and Hepatology 1992; 4: 697-702."},{"key":"ref_2","first-page":"491","article-title":"Omeprazole plus amoxicillin: efficacy of various treatment regimens to eradicate Helicobacter pylori","volume":"88","author":"Labenz, J.; Gyenes, E.; Riihl, G.H.; Borsch, G.","year":"1993","unstructured":"Labenz J, Gyenes E, Riihl GH, Borsch G. Omeprazole plus amoxicillin: efficacy of various treatment regimens to eradicate Helicobacter pylori. 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Gut 1993; 34: 1167-70.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0140-6736(92)90502-T","article-title":"Clarithromycin and omeprazole for Helicobacter pylori","volume":"340","author":"Logan, R.P.H.; Gummett, P.A.; Hegarty, B.T.; Walker, M.M.; Baron, J.H.; Misiewicz, J.J.","year":"1992","unstructured":"Logan RPH, Gummett PA, Hegarty BT, Walker MM, Baron JH, Misiewicz JJ. Clarithromycin and omeprazole for Helicobacter pylori. Lancet 1992; 340: 239.","journal-title":"Lancet"},{"key":"ref_5","first-page":"325","article-title":"Amoxicillin added to omeprazole prevents relapse in the treatment of duodenal ulcer patients","volume-title":"European Journal of Gastroenterology and Hepatology 1993; 5","author":"Unge, P.; Gad, A.; Eriksson, K.; Bergman, B.; Carling, L.; Ekstrom, P.","unstructured":"Unge P, Gad A, Eriksson K, Bergman B, Carling L, Ekstrom P, et al. Amoxicillin added to omeprazole prevents relapse in the treatment of duodenal ulcer patients. European Journal of Gastroenterology and Hepatology 1993; 5: 325-31."},{"key":"ref_6","first-page":"437","article-title":"Qualitative and semiquantitative invasive and non-invasive assessment of Helicobacter pylori colonisation of the gastric mucosa","volume":"31","year":"1993","unstructured":"Labenz J, Stolte M, Aygen S, Hennemann 0, Bertrams J, Borsch G. Qualitative and semiquantitative invasive and non-invasive assessment of Helicobacter pylori colonisation of the gastric mucosa. Z Gastroenterol 1993; 31: 437-43.","journal-title":"Z Gastroenterol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/BF01963775","article-title":"Moellering Jr RC. 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Effect of gastric secretory inhibitors and cisapride on gastric volume in healthy volunteers. European Journal of Gastroenterology and Hepatology 1992; 4: 635-8."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/gut.35.4.455","article-title":"Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds","volume":"35","author":"Verdu, E.; Viani, F.; Armstrong, D.; Fraser, R.; Siegrist, H.H.; Pignatelli, B.","year":"1994","unstructured":"Verdu E, Viani F, Armstrong D, Fraser R, Siegrist HH, Pignatelli B, et al. Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds. Gut 1994; 35: 455-60.","journal-title":"Gut"},{"key":"ref_12","first-page":"481","article-title":"pH and Hp - gastric acid secretion and Helicobacter pylori: implications for ulcer healing and eradication of the organism","volume":"88","author":"Hunt, R.H.","year":"1993","unstructured":"Hunt RH. pH and Hp - gastric acid secretion and Helicobacter pylori: implications for ulcer healing and eradication of the organism. Am J Gastroenterol 1993; 88: 481-3.","journal-title":"Am J Gastroenterol"},{"key":"ref_13","first-page":"726","article-title":"Mediumor high-dose omeprazole plus amoxicillin eradicates Helicobacter pylori in gastric ulcer disease","volume":"89","author":"Labenz, J.; Ruhl, G.H.; Bertrams, J.; Borsch, G.","year":"1994","unstructured":"Labenz J, Ruhl GH, Bertrams J, Borsch G. Mediumor high-dose omeprazole plus amoxicillin eradicates Helicobacter pylori in gastric ulcer disease. 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Schweiz Med Wochenschr 1994; 124: 1391-7.","journal-title":"Schweiz Med Wochenschr"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.37.1.39","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:58:41Z","timestamp":1765637921000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.37.1.39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1995,7,1]]},"published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1136\/gut.37.1.39"],"URL":"https:\/\/doi.org\/10.1136\/gut.37.1.39","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}