{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:45:23Z","timestamp":1765079123540,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>The objective of this study was to conduct a survey of the opinions and practices of gastroenterologists in the United Kingdom concerning the impact of Helicobacter pylori infection on the management of upper gastrointestinal diseases. A postal questionnaire was sent to all medically qualified members of the British Society of Gastroenterology working in the UK. Replies were received from 670 of 1037 eligible BSG members (65%). Of these, 73% thought that H pylori was a cause of duodenal ulcer and 84% thought that eradication of H pylori decreased ulcer recurrence in comparison with acid suppression. While 80% used anti-H pylori therapy for a chronic relapsing duodenal ulcer, only 25% used such therapy for an ulcer at first presentation and 17% never used anti-H pylori therapy for patients with duodenal ulcer. Although 75% of respondents did not agree that H pylori was a cause of non-ulcer dyspepsia, 69% used anti-H pylori therapy to treat a patient with this condition. At the time of the survey, 69% of those who used anti-H pylori therapy adopted some variant of standard triple therapy. Only 7% routinely tested for bacterial sensitivity to antibiotics and only 22% assessed their patients for eradication after treatment. There was a lack of consensus about whether H pylori was a cause of gastric ulcer or gastric cancer with only 47% and 17% respectively believing in these associations. In conclusion, at the time of the survey, the use of anti-H pylori therapy had been accepted by a majority of specialist UK gastroenterologists in the management of upper gastrointestinal disease. There was, however, a substantial degree of uncertainty and divergence about which patients should be treated.<\/jats:p>","DOI":"10.1136\/gut.37.3.314","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"314-318","source":"Crossref","is-referenced-by-count":14,"title":["Helicobacter pylori and upper gastrointestinal disease: a survey of gastroenterologists in the United Kingdom."],"prefix":"10.1136","volume":"37","author":[{"given":"R","family":"Milne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R P","family":"Logan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Harwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Misiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,9,1]]},"reference":[{"key":"ref_1","article-title":"The general confusion about which eradication regimen to adopt was partly shown in the diversity of responses to the open ended question on this subject in the survey. Some of the stated regimens being used were without obvious rationale while others would have resulted in sub-optimal effectiveness (for example, the use of a bismuth drug with a nitroimadozole drug as dual therapy, mentioned by six respondents, or the use of antibiotics in the absence of bismuth or a proton pump inhibitor, mentioned by 22 respondents). Provision of clear advice based on adequately controlled studies may encourage more widespread adoption of eradication therapy","year":"1993","unstructured":"The general confusion about which eradication regimen to adopt was partly shown in the diversity of responses to the open ended question on this subject in the survey. Some of the stated regimens being used were without obvious rationale while others would have resulted in sub-optimal effectiveness (for example, the use of a bismuth drug with a nitroimadozole drug as dual therapy, mentioned by six respondents, or the use of antibiotics in the absence of bismuth or a proton pump inhibitor, mentioned by 22 respondents). Provision of clear advice based on adequately controlled studies may encourage more widespread adoption of eradication therapy. In 1993 the recommended triple therapy was a complex regimen, involving up to 15 tablets a day for two weeks, with widely variable published eradication success rates and major problems of bacterial resistance to nitroimadozoles and adverse side effects.","journal-title":"In; the recommended triple therapy was a complex regimen, involving up to 15 tablets a day for two weeks, with widely variable published eradication success rates and major problems of bacterial resistance to nitroimadozoles and adverse side effects"},{"key":"ref_2","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"i:","author":"Marshall, B.J.","year":"1983","unstructured":"Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; i: 1273-5.","journal-title":"Lancet"},{"key":"ref_3","first-page":"124","article-title":"Helicobacter pylori and chronic gastritis","volume-title":"pylori and gastroduodenal disease","author":"Dixon, M.F.","year":"1992","unstructured":"Dixon MF. Helicobacter pylori and chronic gastritis. In: Rathbone BJ, Heatley RV, eds. Helicobacter pylori and gastroduodenal disease. Oxford: Blackwell Scientific, 1992: 124-39."},{"key":"ref_4","first-page":"140","article-title":"Helicobacter pylori, duodenitis and duodenal ulceration","volume-title":"pylon and gastroduodenal disease","author":"Wyatt, J.I.","year":"1992","unstructured":"Wyatt JI. Helicobacter pylori, duodenitis and duodenal ulceration. In: Rathbone BJ, Heatley RV, eds. Helicobacter pylon and gastroduodenal disease. 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In: Hunt RH, Tytgat GNJ, eds. Helicobacter pylon: basic mechanisms to clinical cure. Dordrecht: Kluwer, 1994: 550-69."},{"key":"ref_8","article-title":"Diffusion of innovations","author":"Rogers, E.M.","year":"1993","unstructured":"Rogers EM. Diffusion of innovations. 3rd ed. New York: Free Press, 1993.","edition":"3rd ed"},{"key":"ref_9","first-page":"727","article-title":"Maintenance therapy in duodenal and gastric ulcer disease: survey of practice amongst British gastroenterologists","volume":"6","author":"Boyd, E.J.S.; Penston, J.G.; Wormsley, K.G.","year":"1992","unstructured":"Boyd EJS, Penston JG, Wormsley KG. Maintenance therapy in duodenal and gastric ulcer disease: survey of practice amongst British gastroenterologists. Aliment Pharmacol Ther 1992; 6: 727-37.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.34.2.284","article-title":"Consultant staffing and career prospects in gastroenterology for England and Wales","volume":"34","author":"Neale, G.; Williams, R.","year":"1993","unstructured":"Neale G, Williams R. Consultant staffing and career prospects in gastroenterology for England and Wales. Gut 1993; 34: 284-7.","journal-title":"Gut"},{"key":"ref_11","first-page":"1716","article-title":"Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori","volume":"87","author":"Chiba, N.; Rao, B.; Rademaker, J.W.; Hunt, R.H.","year":"1992","unstructured":"Chiba N, Rao B, Rademaker JW, Hunt RH. Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori. Am Jf Gastroenterol 1992; 87: 1716-27.","journal-title":"Am Jf Gastroenterol"},{"key":"ref_12","first-page":"36","article-title":"Helicobacter pylon: causal agent in peptic ulcer disease? Working Party Reports: World Congress of Gastroenterology","author":"Tytgat, G.N.J.; Axon, A.T.; Dixon, M.F.; Graham, D.Y.; Lee, A.; Marshall, B.J.","year":"1990","unstructured":"Tytgat GNJ, Axon AT, Dixon MF, Graham DY, Lee A, Marshall BJ. Helicobacter pylon: causal agent in peptic ulcer disease? Working Party Reports: World Congress of Gastroenterology, Sydney. Oxford: Blackwell Scientific, 1990: 36-45."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1136\/bmj.302.6782.919","article-title":"Duodenal ulcer: the villain unmasked","volume":"302","author":"Axon, A.T.R.","year":"1991","unstructured":"Axon ATR. Duodenal ulcer: the villain unmasked. BMJ 1991; 302: 919-21.","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1365-2036.1994.tb00304.x","article-title":"Helicobacter pylori eradication - understandable caution but no cause for inertia","volume":"8","author":"Penston, J.G.","year":"1994","unstructured":"Penston JG. Helicobacter pylori eradication - understandable caution but no cause for inertia. Aliment Pharmacol Ther 1994; 8: 369-89.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref_15","first-page":"773","article-title":"Short term low dose triple therapy for the eradication of Helicobacter pylori","volume-title":"European J7ournal of Gastroenterology and Hepatology","volume":"6","author":"Bazzoli, F.; Zagari, R.M.; Fossi, S.; Pozzato, P.; Alampi, G.; Simoni, P.","year":"1994","unstructured":"Bazzoli F, Zagari RM, Fossi S, Pozzato P, Alampi G, Simoni P, et al. Short term low dose triple therapy for the eradication of Helicobacter pylori. European J7ournal of Gastroenterology and Hepatology 1994; 6: 773-7."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/gut.35.3.323","article-title":"Eradication of Helicobacter pylori with clarithromycin and omeprazole","volume":"35","author":"Logan, R.P.H.; Gummett, P.A.; Schaufelberger, H.D.; Greaves, R.R.F.H.; Mendelson, G.M.; Walker, M.M.","year":"1994","unstructured":"Logan RPH, Gummett PA, Schaufelberger HD, Greaves RRFH, Mendelson GM, Walker MM, et al. Eradication of Helicobacter pylori with clarithromycin and omeprazole. Gut 1994; 35: 323-6.","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/0016-5085(94)90007-8","article-title":"A critique of therapeutic trials in Helicobacter pylori positive functional dyspepsia","volume":"106","author":"Talley, N.J.","year":"1994","unstructured":"Talley NJ. A critique of therapeutic trials in Helicobacter pylori positive functional dyspepsia. Gastroenterology 1994; 106: 1174-83.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.37.3.314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T07:20:10Z","timestamp":1757316010000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.37.3.314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1995,9,1]]},"published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1136\/gut.37.3.314"],"URL":"https:\/\/doi.org\/10.1136\/gut.37.3.314","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}