{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:06:19Z","timestamp":1765634779737,"version":"3.48.0"},"reference-count":32,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>Fifty patients with suspected intra-abdominal abscess were investigated prospectively with ultrasound and with 99mTc-hexamethylpropylene-amine oxime (HMPAO) isotope labelled mixed leucocytes, using 111-In tropolonate granulocyte scanning as the reference standard. Twenty five patients had inflammatory bowel disease (three were postoperative): 21 of these had Crohn's disease and four had ulcerative colitis. The remainder comprised nine with postoperative fever and 16 with fever and abdominal pain. An abscess was diagnosed when focal activity on serial 111-In tropolonate and 99m-Tc-HMPOA images at one, three, and 24 hours resulted in activity at least equal to liver activity at 24 hours. Thirteen abscesses were diagnosed using each type of white cell scanning, resulting in 100% sensitivity for 99m-Tc-HMPAO compared with 111-In tropolonate. Bowel inflammation was easily distinguished from abscess on serial images. Eight of these 13 abscesses were detected by ultrasound. Altogether 17 abscesses were found. Ultrasound detected 12, including four liver abscesses which were not purulent and had not been detected by white cell scanning. Ultrasound had a sensitivity of 71% (12 of 17) and a specificity of 87% (33 of 38) using all confirmed abscesses as the reference standard. White cell scanning showed a sensitivity of 76% (13 of 17: as a result of the four non-purulent liver abscesses) and a specificity of 100%. 99m-Tc-HMPAO scanning is as accurate as 111-In tropolonate scanning, and has several advantages including simplicity, availability, superior image quality, and reduced radiation dose. Both methods are more sensitive and specific than ultrasound for intra-abdominal abscess detection but ultrasound is advisable if a neutrophil infiltrate is not suspected.<\/jats:p>","DOI":"10.1136\/gut.37.4.557","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"557-564","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess."],"prefix":"10.1136","volume":"37","author":[{"given":"M J","family":"Weldon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"French","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S H","family":"Saverymuttu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"ref_1","first-page":"517","article-title":"Determinants of death in patients with intraabdominal abscess","volume":"88","author":"Fry, D.E.; Garrison, R.N.; Heitsch, R.C.; Calhoun, K.; Polk, H.C.","year":"1980","unstructured":"Fry DE, Garrison RN, Heitsch RC, Calhoun K, Polk HC. 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Eiur 7 Radiol 1989; 9: 134-6."},{"key":"ref_15","first-page":"946","article-title":"Clinical experience with 'QmTchexamethylpropylene-amineoxime for labelling leucocvtes and imaging inflammation","volume":"ii:","author":"Peters, A.M.; Danpure, H.J.; Osman, S.; Hawker, R.J.; Henderson, B.L.; Hodgson, H.J.","year":"1986","unstructured":"Peters AM, Danpure HJ, Osman S, Hawker RJ, Henderson BL, Hodgson HJ, et al. Clinical experience with 'QmTchexamethylpropylene-amineoxime for labelling leucocvtes and imaging inflammation. Lanicet 1986; ii: 946-9.","journal-title":"Lanicet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00006231-198806000-00008","article-title":"Comparison of 9`Tcm-HMPAO andlIn-oxine labelled granulocytes in man: first clinical results","volume":"9","author":"Becker, W.; Schomann, E.; Fischbach, W.; Borner, W.; Gruner, K.R.","year":"1988","unstructured":"Becker W, Schomann E, Fischbach W, Borner W, Gruner KR. 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B7 Radiol 1982; 55: 247-9."},{"key":"ref_19","first-page":"465","article-title":"The development of a clinical protocol for the radiolabelling of mixed leucocvtes with 99mTc hexamethyl propylene amine oxime","volume":"9","author":"Danpure, H.J.; Osman, S.; Carroll, M.J.","year":"1988","unstructured":"Danpure HJ, Osman S, Carroll MJ. The development of a clinical protocol for the radiolabelling of mixed leucocvtes with 99mTc hexamethyl propylene amine oxime. Nucl Mcd Comnunim 1988; 9: 465-75.","journal-title":"Nucl Mcd Comnunim"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0016-5085(86)90376-8","article-title":"Indium 111 -granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. 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Ani _7 Suirg 1980, 140: 675-8."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.37.4.557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:02:19Z","timestamp":1765634539000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.37.4.557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1995,10,1]]},"published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1136\/gut.37.4.557"],"URL":"https:\/\/doi.org\/10.1136\/gut.37.4.557","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}