{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:42:05Z","timestamp":1770507725575,"version":"3.49.0"},"reference-count":22,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:p>BACKGROUND: The precise site of intestinal permeability changes in patients with coeliac and inflammatory bowel disease is unknown. AIMS: To design a non-invasive technique for the localisation of altered gastrointestinal permeability to 51chromium labelled EDTA (51CrEDTA). The method depends on comparing and defining concentration\/time profiles in serum of a series of simultaneously ingested indicators with a well defined absorption site (3-0-methyl-D-glucose (jejunal indicator), 57cobalt labelled vitamin B12 (ileal indicator), and sulphasalazine (caecal-colonic indicator)) in relation to simultaneously ingested 51CrEDTA. SUBJECTS: Five normal controls, six patients with untreated coeliac disease, five with Crohn's ileitis, and five with pan-ulcerative colitis underwent study, which entailed the simultaneous ingestion of the above four test substances followed, during the next 24 hours, by timed serial collection of urine and serum for marker analysis. RESULTS: Urinary excretion of 51CrEDTA was significantly increased in all patient groups. Analysis of serum appearances and profiles of the markers suggested that the increased intestinal permeation of 51CrEDTA took place in the diseased jejunum in patients with coeliac disease, predominantly in the ileum in Crohn's disease and in the colon in the patients with pan-ulcerative colitis. CONCLUSION: A new non-invasive technique has been assessed that permits the localisation of the site of permeability changes with the gastrointestinal tract.<\/jats:p>","DOI":"10.1136\/gut.38.6.864","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"864-869","source":"Crossref","is-referenced-by-count":26,"title":["Assessing the site of increased intestinal permeability in coeliac and inflammatory bowel disease."],"prefix":"10.1136","volume":"38","author":[{"given":"K","family":"Teahon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Somasundaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Menzies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Bjarnason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,6,1]]},"reference":[{"key":"ref_1","first-page":"527","article-title":"Transmucosal passages of inert molecules in health and disease","author":"Menzies, I.S.","year":"1984","unstructured":"Menzies IS. Transmucosal passages of inert molecules in health and disease. In: Skadhauge E, Heintze K, eds. Intestinal absorption and secretion. Falk Symposium 36. Lancaster: MTP Press, 1984: 527-43."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/0016-5085(95)90708-4","article-title":"Intestinal permeability: an overview","volume":"108","author":"Bjarnason, I.; Macpherson, A.; Hollander, D.","year":"1995","unstructured":"Bjarnason I, Macpherson A, Hollander D. Intestinal permeability: an overview. Gastroenterology 1995; 108: 1566-81.","journal-title":"Gastroenterology"},{"key":"ref_3","first-page":"630","article-title":"Catt 5, Peters TJ, Menzies IS. A comparison of 4 markers of intestinal permeability in control subjects and patients with coeliac disease","volume":"26","author":"Bjarnason, I.; Maxton, D.; Reynolds, A.P.","year":"1993","unstructured":"Bjarnason I, Maxton D, Reynolds AP, Catt 5, Peters TJ, Menzies IS. A comparison of 4 markers of intestinal permeability in control subjects and patients with coeliac disease. ScandJf Gastroenterol 1993; 26: 630-9.","journal-title":"ScandJf Gastroenterol"},{"issue":"7","key":"ref_4","first-page":"1","article-title":"Lactulose, 51 GrEDTA, L-rhamnose and polyethylene glycol 400 as probe markers for 'in vivo' assessment of human intestinal permeability","volume":"71","author":"Maxton, D.G.; Bjarnason, I.; Reynolds, A.P.; Catt, S.D.; Peters, T.J.; Menzies, I.S.","year":"1986","unstructured":"Maxton DG, Bjarnason I, Reynolds AP, Catt SD, Peters TJ, Menzies IS. Lactulose, 51 GrEDTA, L-rhamnose and polyethylene glycol 400 as probe markers for 'in vivo' assessment of human intestinal permeability. Clin Sci 1986; 71: 7 1-80.","journal-title":"Clin Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3109\/00365529209011181","article-title":"Simultaneous administration of lactulose and 51 Cr-ethylenediaminetetraacetic acid. A test to distinguish colonic from small-intestinal permeability change","volume":"27","author":"Jenkins, A.P.; Nukajam, W.S.; Menzies, I.S.; Creamer, B.","year":"1992","unstructured":"Jenkins AP, Nukajam WS, Menzies IS, Creamer B. Simultaneous administration of lactulose and 51 Cr-ethylenediaminetetraacetic acid. A test to distinguish colonic from small-intestinal permeability change. Scand Jf Gastroenterol 1992; 27: 769-73.","journal-title":"Scand Jf Gastroenterol"},{"key":"ref_6","first-page":"430","article-title":"The effect of pelvic irradiation on small and large intestinal absorption","volume-title":"and permeability in man. Gastroenterology","volume":"106","author":"Qvist, H.; Somasundaram, S.; Macpherson, A.; Menzies, I.S.; Giercksky, K.; Bjarnason, I.","year":"1994","unstructured":"Qvist H, Somasundaram S, Macpherson A, Menzies IS, Giercksky K, Bjarnason I. The effect of pelvic irradiation on small and large intestinal absorption and permeability in man. Gastroenterology 1994; 106: A430."},{"issue":"57","key":"ref_7","first-page":"883","article-title":"Sugar absorption tests, with special reference to 3-0-methyl-Dglucose and D-xylose","volume":"1962","author":"Fordtran, J.S.; Clodi, P.H.; Soergel, K.H.; Ingelfinger, J.F.","unstructured":"Fordtran JS, Clodi PH, Soergel KH, Ingelfinger JF. Sugar absorption tests, with special reference to 3-0-methyl-Dglucose and D-xylose. Ann Intern Med 1962; 57: 883-91.","journal-title":"Ann Intern Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1172\/JCI110788","article-title":"Intrinsic-factor mediated absorption of cobalamine by pig ileal cells","volume":"71","author":"Kapadia, C.R.; Serfilippi, C.; Voloshin, K.D.R.","year":"1983","unstructured":"Kapadia CR, Serfilippi C, Voloshin KDR. Intrinsic-factor mediated absorption of cobalamine by pig ileal cells. Jf Clin Invest 1983; 71: 440-7.","journal-title":"Jf Clin Invest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0016-5085(86)90574-3","article-title":"Sulphapyridine appearance in plasma after salicylazosulfapyridine","volume":"91","author":"Kellow, J.E.; Borody, T.J.; Phillips, S.F.; Haddad, A.C.; Brown, M.L.","year":"1986","unstructured":"Kellow JE, Borody TJ, Phillips SF, Haddad AC, Brown ML. Sulphapyridine appearance in plasma after salicylazosulfapyridine. Gastroenterology 1986; 91: 396-400.","journal-title":"Gastroenterology"},{"key":"ref_10","first-page":"439","article-title":"Development of a Crohn's disease activity index","volume":"70","author":"Best, W.R.; Becktel, J.M.; Singleton, J.W.; Kern, F.","year":"1975","unstructured":"Best WR, Becktel JM, Singleton JW, Kern F. Development of a Crohn's disease activity index. Gastroenterology 1975; 70: 439-44.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","article-title":"Cortisone in ulcerative colitis. Final report on a therapeutic trial","volume":"2","author":"Truelove, S.C.; Witts, U.","year":"1955","unstructured":"Truelove SC, Witts U. Cortisone in ulcerative colitis. Final report on a therapeutic trial. BMJ 1955; 2: 1041-8.","journal-title":"BMJ"},{"key":"ref_12","first-page":"434","article-title":"Delay of absorption of radiolabelled cyanocobalamine in the intestinal wall in the presence of intrinsic factor","volume":"54","author":"Doscherholmen, A.; Hagen, P.S.","year":"1959","unstructured":"Doscherholmen A, Hagen PS. Delay of absorption of radiolabelled cyanocobalamine in the intestinal wall in the presence of intrinsic factor. 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Absorption of vitamin B 12 by the guinea pig. I subcellular localisation ofvitamin B 12 in ileal enterocyte during absorption. Br J Haematol 1970; 19: 369-82.","journal-title":"Br J Haematol"},{"key":"ref_17","first-page":"617","article-title":"The subcellular localisation of vitamin B 12 during absorption in guinea pig ileum","volume":"22","author":"Jenkins, W.I.; Empsow, R.; Jewel, D.P.; Taylor, K.B.","year":"1982","unstructured":"Jenkins WI, Empsow R, Jewel DP, Taylor KB. The subcellular localisation of vitamin B 12 during absorption in guinea pig ileum. Gut 1982; 22: 617-23.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gut.25.2.145","article-title":"In vitro determination of intestinal permeability: demonstration of a persisting defect in patients with coeliac disease","volume":"25","author":"Bjamason, I.; Peters, T.J.","year":"1984","unstructured":"Bjamason I, Peters TJ. In vitro determination of intestinal permeability: demonstration of a persisting defect in patients with coeliac disease. Gut 1984; 25: 145-50.","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/cs0740427","article-title":"Changes in jejunal permeability and passive permeation of sugars in intestinal biopsies in coeliac disease and Crohn's disease","volume":"74","author":"Dawson, D.J.; Lobley, R.W.; Burrows, P.C.; Notman, J.A.; Mahon, M.; Holmes, R.","year":"1988","unstructured":"Dawson DJ, Lobley RW, Burrows PC, Notman JA, Mahon M, Holmes R. Changes in jejunal permeability and passive permeation of sugars in intestinal biopsies in coeliac disease and Crohn's disease. Clin Sci 1988; 74: 427-31.","journal-title":"Clin Sci"},{"key":"ref_20","first-page":"254","article-title":"Structural abnormalities of jejunal epithelial cell membranes in coeliac sprue","volume":"43","author":"Madara, J.L.; Trier, J.S.","year":"1980","unstructured":"Madara JL, Trier JS. Structural abnormalities of jejunal epithelial cell membranes in coeliac sprue. Lab Invest 1980; 43: 254-61.","journal-title":"Lab Invest"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/00365521.1970.12096604","article-title":"Absorption of 51 CrEDTA in ulcerative colitis following rectal instillation","volume":"5","author":"Rask-Madsen, J.; Schwartz, M.","year":"1979","unstructured":"Rask-Madsen J, Schwartz M. Absorption of 51 CrEDTA in ulcerative colitis following rectal instillation. Scand J Gastroenterol 1979; 5: 361-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_22","first-page":"430","article-title":"Das KM.51CrEDTA a useful test in the assessment of inflammatory bowel disease","volume":"108","author":"O'Morain, C.; Abelon, A.C.; Chervli, L.R.; Fleischner, G.M.","year":"1986","unstructured":"O'Morain C, Abelon AC, Chervli LR, Fleischner GM, Das KM.51CrEDTA a useful test in the assessment of inflammatory bowel disease. 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