{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:20:39Z","timestamp":1775121639002,"version":"3.50.1"},"reference-count":32,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:p>BACKGROUND: In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) provides biochemical information about phosphorus metabolism. AIM: To assess 31P MRS as a prognostic marker in patients with primary biliary cirrhosis (PBC) in relation to the current clinical prognostic models. PATIENTS AND METHODS: Twenty three patients with PBC of varying functional severity and 16 matched healthy volunteers were studied using in vivo 31P MRS. Spectra were acquired using a 1.5 T spectroscopy system. Peak area ratios of phosphomonoesters (PME), inorganic phosphate (Pi), and phosphodiesters (PDE) and nucleotide triphosphate (NTP) were calculated. Pugh score, Christensen prognostic index, and R value according to the Mayo model were calculated from the clinical data. RESULTS: The PME\/NTP, Pi\/NTP, PME\/PDE, and PME\/Pi ratios and the PME signal height ratio (SHR) were significantly higher, while the PDE\/NTP and PDE\/SHR were significantly lower in PBC patients compared with healthy volunteers (p &lt; 0.01). Significant correlations were seen between PME\/Pi ratio and the prognostic index according to Christensen (r = 0.63, p &lt; 0.001), R value according to the Mayo model (r = 0.45, p &lt; 0.03), and with the Pugh score (r = 0.55, p &lt; 0.007). CONCLUSIONS: This study shows that PME\/Pi ratio obtained from 31P MRS correlates well with all three of the commonly used models of prognosis in patients with PBC. A longitudinal study with larger number of patients is required to confirm these findings and elucidate the biochemical changes underlying this phenomenon.<\/jats:p>","DOI":"10.1136\/gut.39.1.141","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"141-146","source":"Crossref","is-referenced-by-count":34,"title":["Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models."],"prefix":"10.1136","volume":"39","author":[{"given":"R","family":"Jalan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sargentoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G A","family":"Coutts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Rolles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Burroughs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Taylor Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.7326\/0003-4819-99-4-500","article-title":"Primary biliary cirrhosis: A model autoimmune disease","volume":"99","author":"James, S.P.; Hoofnagle, J.H.; Strober, W.; Jones, E.A.","year":"1983","unstructured":"James SP, Hoofnagle JH, Strober W, Jones EA. 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Anti-mitochondrial antibody profiles determined at early stages of primary biliary cirrhosis differentiate between a benign and a progressive course of disease. J Hepatol 1991; 21: 21-7.","journal-title":"J Hepatol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/hep.1840100402","article-title":"Frequency of IgG and IgM antibodies to four specific M 2 mitochondrial auto antigens in primary biliary cirrhosis","volume":"10","author":"Mutimer, D.J.; Fussey, S.P.M.; Yeaman, S.J.; Kelly, P.J.; James, O.F.W.; Bassendine, M.F.","year":"1989","unstructured":"Mutimer DJ, Fussey SPM, Yeaman SJ, Kelly PJ, James OFW, Bassendine MF. Frequency of IgG and IgM antibodies to four specific M 2 mitochondrial auto antigens in primary biliary cirrhosis. 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Accurate prediction of death by serial determination of galactose elimination capacity in primary biliary cirrhosis: A comparison with the Mayo model. 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