{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:58:37Z","timestamp":1772816317591,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p>BACKGROUND\/AIMS: Calcium and vitamin D malabsorption in coeliac disease predispose to skeletal demineralisation. This study aimed to determine bone mineral density in patients studied in the first year after diagnosis of coeliac disease, and to detect changes in bone mineral density over the subsequent year. METHODS: Lumbar spine and femoral neck bone mineral density was measured in 21 adults with coeliac disease, diagnosed and started on a gluten free diet during the preceding year, with dual energy x ray absorptiometry and repeated after 12 months. RESULTS: Bone mineral density was significantly lower in patients than in paired controls (matched for age and sex), at lumbar spine (0.819 g\/cm2 compared with 1.021 g\/cm2, p &lt; 0.001 Wilcoxon signed rank test) and femoral neck (0.663 g\/cm2 compared with 0.794 g\/cm2, p &lt; 0.001). Repeat measurement after 12 months demonstrated that patients had a significant gain in bone mineral density at lumbar spine (16.6%\/year), and femoral neck (15.5%\/year, p &lt; 0.002, Wilcoxon signed rank test at both sites), whereas no significant change in bone mineral density was detected in controls. CONCLUSIONS: Treatment of coeliac disease with a gluten free diet is associated with a significant increase in bone mineral density, although patients still had lower bone mineral density than controls.<\/jats:p>","DOI":"10.1136\/gut.39.2.180","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"180-184","source":"Crossref","is-referenced-by-count":90,"title":["Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease."],"prefix":"10.1136","volume":"39","author":[{"given":"X A","family":"McFarlane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,8,1]]},"reference":[{"key":"ref_1","first-page":"1078","article-title":"Celiac sprue. In: Sleisenger MH, Fordtran JF. Gastrointestinal diseases. Pathophysiology, diagnosis, management","author":"Trier, J.S.","year":"1993","unstructured":"Trier JS. Celiac sprue. In: Sleisenger MH, Fordtran JF. Gastrointestinal diseases. Pathophysiology, diagnosis, management. Philadelphia: W B Saunders, 1993: 1078-96."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-196401000-00001","article-title":"Adult coeliac disease with emphasis on the response to the gluten free diet","volume":"43","author":"Benson, G.D.; Kowlessar, O.D.; Sleisenger, M.H.","year":"1964","unstructured":"Benson GD, Kowlessar OD, Sleisenger MH. Adult coeliac disease with emphasis on the response to the gluten free diet. Medicine 1964; 43: 1-40.","journal-title":"Medicine"},{"key":"ref_3","first-page":"51","article-title":"BMD in adult coeliac patients and the effect of a gluten free diet from childhood","volume":"85","author":"Molteni, N.; Caraceni, M.P.; Bardella, M.T.; Ortolani, S.; Gandolini, G.G.; Bianchi, P.","year":"1990","unstructured":"Molteni N, Caraceni MP, Bardella MT, Ortolani S, Gandolini GG, Bianchi P. BMD in adult coeliac patients and the effect of a gluten free diet from childhood. Am J Gastroenterol 1990; 85: 51-3.","journal-title":"Am J Gastroenterol"},{"key":"ref_4","first-page":"274","article-title":"Bone and mineral metabolism in adult coeliac disease","volume":"83","author":"Caraceni, M.P.; Molteni, N.; Bardella, M.T.; Ortolani, S.; Nogara, A.; Bianchi, P.A.","year":"1988","unstructured":"Caraceni MP, Molteni N, Bardella MT, Ortolani S, Nogara A, Bianchi PA. Bone and mineral metabolism in adult coeliac disease. Am J Gastroenterol 1988; 83: 274-7.","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"ref_5","first-page":"1","article-title":"A patient with osteomalacia as a single presenting symptom of gluten sensitive enteropathy","volume":"232","author":"WA, De Boer; GN, Tytgat","year":"1992","unstructured":"De Boer WA, Tytgat GN. A patient with osteomalacia as a single presenting symptom of gluten sensitive enteropathy. J Intern Med 1992; 232: 8 1-5.","journal-title":"J Intern Med"},{"key":"ref_6","first-page":"82","article-title":"Calcium metabolism and bone pathology in adult coeliac disease","volume":"39","author":"Melvin, K.; Hepner, G.; Bordier, P.; Neale, G.; Joplin, G.","year":"1970","unstructured":"Melvin K, Hepner G, Bordier P, Neale G, Joplin G. Calcium metabolism and bone pathology in adult coeliac disease. QJ Med 1970; 39: 82-113.","journal-title":"QJ Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02555705","article-title":"The definition and diagnosis of osteoporosis","volume":"40","author":"Editorial, Nordin B.E.C.","year":"1987","unstructured":"Nordin BEC. Editorial. The definition and diagnosis of osteoporosis. Calif Tissue Int 1987; 40: 57-8.","journal-title":"Calif Tissue Int"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"Perspective: The diagnosis of osteoporosis","volume":"9","author":"Kanis, J.A.; Melton, J.; Christiansen, C.; Johnston, C.C.; Khaltev, N.","year":"1994","unstructured":"Kanis JA, Melton J, Christiansen C, Johnston CC, Khaltev N. Perspective: The diagnosis of osteoporosis. Y Bone Miner Res 1994; 9: 1137-41.","journal-title":"Y Bone Miner Res"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0140-6736(93)92555-8","article-title":"Bone density at various sites for prediction of hip fractures. The study of osteoporotic fractures research group","volume":"341","author":"Cummings, SR, Black; DM, Nevitt; MC, Browner; W, Cauley; J, Ensrud; K.","year":"1993","unstructured":"Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, et al. Bone density at various sites for prediction of hip fractures. The study of osteoporotic fractures research group. Lancet 1993; 341: 72-5.","journal-title":"Lancet"},{"key":"ref_10","first-page":"2","article-title":"Uses and limitations of bone biopsy in management of metabolic bone disease","volume":"1988","author":"Boyce, B.F.","unstructured":"Boyce BF. Uses and limitations of bone biopsy in management of metabolic bone disease. Ballieres Clin Endocrinol Metab 1988: 2: 31-57.","journal-title":"Ballieres Clin Endocrinol Metab"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.36.5.710","article-title":"Osteoporosis in treated adult coeliac disease","volume":"36","author":"McFarlane, X.A.; Bhalla, A.K.; Reeves, D.E.; Morgan, L.M.; Robertson, D.A.F.","year":"1995","unstructured":"McFarlane XA, Bhalla AK, Reeves DE, Morgan LM, Robertson DAF. Osteoporosis in treated adult coeliac disease. Gut 1995; 36: 710-4.","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/8756-3282(94)00034-W","article-title":"Body composition and bone mineral density in treated and untreated patients with coeliac disease","volume":"16","author":"Gonzalez, D.; Mazure, R.; Mautalen, C.; Vazquez, H.; Bai, J.","year":"1995","unstructured":"Gonzalez D, Mazure R, Mautalen C, Vazquez H, Bai J. Body composition and bone mineral density in treated and untreated patients with coeliac disease. Bone 1995; 16: 231-4.","journal-title":"Bone"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/ajcn\/57.2.224","article-title":"Effect of gluten free diet on bone mineral content in growing patients with coeliac disease","volume":"57","author":"Mora, S.; Weber, G.; Barera, G.; Bellini, G.; Bellini, A.; Pasolini, D.","year":"1993","unstructured":"Mora S, Weber G, Barera G, Bellini G, Bellini A, Pasolini D, et al. Effect of gluten free diet on bone mineral content in growing patients with coeliac disease. Am Y Clin Nutr 1993; 57: 224-8.","journal-title":"Am Y Clin Nutr"},{"key":"ref_14","first-page":"398","article-title":"The female osteoporotic syndrome(s)","volume-title":"SM. Metabolic bone disease and clinically related disorders","author":"Avioli, L.V.; Lindsay, R.","year":"1990","unstructured":"Avioli LV, Lindsay R. The female osteoporotic syndrome(s). In: Avioli LV, Krane SM. Metabolic bone disease and clinically related disorders. Philadelphia: W B Saunders, 1990: 398-451."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/edrv-7-4-379","article-title":"Normal and pathological remodelling of human trabecular bone: three dimensional reconstruction of the remodelling sequence in normal and in metabolic bone disease","volume":"7","author":"Eriksen, E.F.","year":"1986","unstructured":"Eriksen EF. Normal and pathological remodelling of human trabecular bone: three dimensional reconstruction of the remodelling sequence in normal and in metabolic bone disease. Endocr Rev 1986; 7: 379-408.","journal-title":"Endocr Rev"},{"key":"ref_16","first-page":"827","article-title":"Measurement of the 10,000 molecular weight calcium binding protein in small intestinal biopsy specimens from patients with malabsorption syndromes","volume":"23","author":"Staun, M.; Jarnum, S.","year":"1988","unstructured":"Staun M, Jarnum S. Measurement of the 10,000 molecular weight calcium binding protein in small intestinal biopsy specimens from patients with malabsorption syndromes. ScandJrGastroenterol 1988; 23: 827-32.","journal-title":"ScandJrGastroenterol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0016-5085(95)27269-0","article-title":"Intestinal strontium absorption and bone mineral density in treated adult coeliac disease","volume":"108","author":"McFarlane, X.A.; Bhalla, A.K.; Robertson, D.A.F.","year":"1995","unstructured":"McFarlane XA, Bhalla AK, Robertson DAF. Intestinal strontium absorption and bone mineral density in treated adult coeliac disease. Gastroenterology 1995; 108: A739.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.39.2.180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:36:55Z","timestamp":1765651015000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.39.2.180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1996,8,1]]},"published-print":{"date-parts":[[1996,8]]}},"alternative-id":["10.1136\/gut.39.2.180"],"URL":"https:\/\/doi.org\/10.1136\/gut.39.2.180","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8]]}}}