{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:56:22Z","timestamp":1773100582878,"version":"3.50.1"},"reference-count":31,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:p>BACKGROUND: The occurrence of gall stones has repeatedly been associated with an increased risk for cancer of the colon, but risk associated with cholecystectomy remains unclear. AIMS: To evaluate the hypothesis in a nationwide cohort of more than 40,000 gall stone patients with complete follow up including information of cholecystectomy and obesity. PATIENTS: In the population based study described here, 42,098 patients with gall stones in 1977-1989 were identified in the Danish Hospital Discharge Register. METHODS: These patients were linked to the Danish Cancer Registry to assess their risks for colorectal and other cancers during follow up to the end of 1992. RESULTS: The analysis showed a modest increase in the number of cancers at all sites combined (n = 3940; RR, 1.07; 95% confidence intervals (CI), 1.0 to 1.1). A weak association was found for cancer of the colon (n = 360; RR, 1.09; 95% CI 1.0 to 1.2), which remained unchanged when analysed by sex, anatomical subsite, and duration of follow up. Multivariate analysis with adjustment for cholecystectomy and clinically defined obesity did not change these estimates to any significant extent. Excess risks were found for cancers of the pancreas and the small intestine. A non-significant increased risk for breast cancer was seen in women five years after initial discharge for gall stones. CONCLUSION: A borderline significant association was seen between gall stones and cancer of the colon, and for cancer of pancreas and small intestine as well as for breast cancer in women.<\/jats:p>","DOI":"10.1136\/gut.39.3.439","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"439-443","source":"Crossref","is-referenced-by-count":63,"title":["Risk of colorectal cancer and other cancers in patients with gall stones."],"prefix":"10.1136","volume":"39","author":[{"given":"C","family":"Johansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W H","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mellemkjaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Engholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,9,1]]},"reference":[{"key":"ref_1","first-page":"535","article-title":"Faecal bile-acids and Clostridia in patients with cancer of the large bowel","volume":"i:","author":"Hill, M.J.; Drasar, B.S.; Williams, R.E.O.","year":"1975","unstructured":"Hill MJ, Drasar BS, Williams REO, et al. 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Cholelitihasis - cholezystektomie und kolonkarzinom. Zentralbl Chir 1983; 108: 449-56.","journal-title":"Zentralbl Chir"},{"key":"ref_7","first-page":"51","article-title":"Gallbladder disease: risk factor for colorectal carcinoma?","volume":"6","author":"Allende, H.; Ona, F.V.; Davis, H.T.","year":"1984","unstructured":"Allende H, Ona FV, Davis HT. Gallbladder disease: risk factor for colorectal carcinoma? Jf Clin Gastroenterol 1984; 6: 51-5.","journal-title":"Jf Clin Gastroenterol"},{"key":"ref_8","first-page":"22","article-title":"Explorative untersuchungen zum gemeinsamen vorkommen von cholelithiasis zustand nach cholezystectomie und kolonkarzinom","volume":"46","author":"Machnik, V.G.; Fuller, C.; Fuller, J.","year":"1986","unstructured":"Machnik VG, Fuller C, Fuller J, et al. Explorative untersuchungen zum gemeinsamen vorkommen von cholelithiasis zustand nach cholezystectomie und kolonkarzinom. Dtsch Z Verdau-Stoffwechs 1986; 46: 22-9.","journal-title":"Dtsch Z Verdau-Stoffwechs"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/BF02561690","article-title":"Prevention of colorectal cancer","volume":"30","author":"Gafa, M.; Sarli, L.; Sansebastiano, G.","year":"1987","unstructured":"Gafa M, Sarli L, Sansebastiano G. Prevention of colorectal cancer. Dis Colon Rectum 1987; 30: 692-6.","journal-title":"Dis Colon Rectum"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.7326\/0003-4819-107-1-30","article-title":"Gallstones, gallbladder cancer, and other gastrointestinal malignancies","volume":"107","author":"Maringhini, A.; Moreau, J.A.; Melton, U.","year":"1987","unstructured":"Maringhini A, Moreau JA, Melton U, et al. Gallstones, gallbladder cancer, and other gastrointestinal malignancies. 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N Engl Jf Med 1973; 289: 1213-6.","journal-title":"N Engl Jf Med"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.2910140203","article-title":"Baanders-van Halewiju EA. A prospective study in general practise on breast cancer risk in postmenopausal women","volume":"14","author":"F, De Ward","year":"1974","unstructured":"De Ward F, Baanders-van Halewiju EA. A prospective study in general practise on breast cancer risk in postmenopausal women. IntJ Cancer 1974; 14: 153-60.","journal-title":"IntJ Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1136\/jech.36.4.274","article-title":"Risk factors for gallbladder disease: a cohort study of young women attending family planning clinics","volume":"36","author":"Layde, P.M.; Vessey, M.P.; Yeates, D.","year":"1982","unstructured":"Layde PM, Vessey MP, Yeates D. Risk factors for gallbladder disease: a cohort study of young women attending family planning clinics. Jf Epidemiol Community Health 1982; 36: 274-8.","journal-title":"Jf Epidemiol Community Health"},{"key":"ref_21","article-title":"The activity in the hospital care system","author":"Danish National Board of Health","year":"1981","unstructured":"Danish National Board of Health. The activity in the hospital care system. Copenhagen: Danish National Board of Health, 1981 [In Danish]."},{"key":"ref_22","article-title":"Classification of diseases","author":"Danish National Board of Health","year":"1976","unstructured":"Danish National Board of Health. Classification of diseases (1976). Copenhagen: Danish National Board of Health, 1986. [In Danish]."},{"key":"ref_23","article-title":"Cancer incidence in Denmark 1990","author":"Storm, H.H.; Manders, T.; Friis, S.","year":"1992","unstructured":"Storm HH, Manders T, Friis S, et al. Cancer incidence in Denmark 1990. Copenhagen: Danish Cancer Society, 1992."},{"key":"ref_24","article-title":"Epidemiologic analysis with a programmable calculator (DHHS Publication No (NIH) 79-1649)","author":"Rothman, K.J.; Boice, J.D.","year":"1979","unstructured":"Rothman KJ, Boice JD. Epidemiologic analysis with a programmable calculator (DHHS Publication No (NIH) 79-1649). Washington DC: US Government Printing Office, 1979."},{"key":"ref_25","article-title":"Statistical methods in cancer research. Vol. II. The design and analysis of cohort studies","volume":"82","author":"Breslow, N.E.; Day, N.E.","year":"1987","unstructured":"Breslow NE, Day NE. Statistical methods in cancer research. Vol. II. The design and analysis of cohort studies. IARC Sci Pub No 82. Lyon: International Agency for Research on Cancer, 1987.","journal-title":"IARC Sci Pub No"},{"key":"ref_26","article-title":"Epicure","author":"Preston, D.L.; Lukin, J.H.; Pierce, D.A.","year":"1993","unstructured":"Preston DL, Lukin JH, Pierce DA, et al. Epicure. Seattle, USA: Hirosoft International Corporation, 1993."},{"key":"ref_27","first-page":"336","article-title":"An epidemiological investigation (thesis)","volume":"37","author":"Gallstones, Joergensen T.","year":"1990","unstructured":"Joergensen T. Gallstones. An epidemiological investigation (thesis). Dan Med Bulletin 1990; 37: 336-46.","journal-title":"Dan Med Bulletin"},{"key":"ref_28","first-page":"113","article-title":"Cancer incidence after cholecystectomy - a cohort study with 30 years follow-up","volume":"15","author":"Gudmundsson, G.; M6ller, T.R.; Olsson, H.","year":"1989","unstructured":"Gudmundsson G, M6ller TR, Olsson H. Cancer incidence after cholecystectomy - a cohort study with 30 years follow-up. EurJ Surg Oncol 1989; 15: 113-7.","journal-title":"EurJ Surg Oncol"},{"key":"ref_29","first-page":"235","article-title":"Cholecystectomy and the incidence of breast cancer: a cohort study","volume":"49","author":"true","year":"1984","unstructured":"Adami H-O, Meirik 0, Gustavsson S, et al. Cholecystectomy and the incidence of breast cancer: a cohort study. BrJrCancer 1984; 49: 235-9.","journal-title":"BrJrCancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1080\/00365521.1984.12005843","article-title":"Lack of relationship between cholecystectomy and colorectal cancer. A case-control study in a defined population","volume":"19","author":"Eriksson, S.G.; Lindstr6, C.G.","year":"1984","unstructured":"Eriksson SG, Lindstr6 CG. Lack of relationship between cholecystectomy and colorectal cancer. A case-control study in a defined population. ScandJ Gastroenterol 1984; 19: 977-82.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/oxfordjournals.aje.a114268","article-title":"A study of a possible association between breast cancer and gallbladder disease","volume":"123","author":"Wysowski, D.K.; Goldberg, E.L.; Comstock, G.W.","year":"1986","unstructured":"Wysowski DK, Goldberg EL, Comstock GW, et al. A study of a possible association between breast cancer and gallbladder disease. 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