{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:56:05Z","timestamp":1765040165448,"version":"3.45.0"},"reference-count":23,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:p>BACKGROUND: Palliation of malignant dysphagia is possible by a variety of methods although all have significant drawbacks. Laser therapy is an effective and safe treatment but has to be repeated at four to five weekly intervals to maintain palliation. A means of augmenting the benefits while reducing the need for repeat treatments would be highly beneficial to these patients. AIMS: To prospectively explore the safety and efficacy of intraluminal radiotherapy (brachytherapy) when used to augment laser recanalisation for malignant dysphagia. PATIENTS: Nineteen patients with dysphagia due to advanced adenocarcinoma of the oesophagus or cardia were recruited. METHODS: All patients received laser recanalisation until able to swallow a soft diet or better, before the application of a single dose of brachytherapy (10 Gy at 1 cm from the source). Patients were followed up and treated promptly by further endoscopic means in the event of their dysphagia worsening. RESULTS: Six patients (32%) required no further treatment until death at a median of 10 weeks (range 1-20 weeks). Further therapy was required at a median of 11 weeks (range 4-37 weeks) after brachytherapy for those 13 patients with recurrent dysphagia. Subsequent symptom control required endoscopic intervention at an average of once every nine weeks. There was no mortality associated with laser or brachytherapy. Median survival from initial treatment and including the one survivor was 36 weeks (range 5-132 weeks). CONCLUSIONS: Laser plus brachytherapy offers a safe and effective means of palliating malignant dysphagia due to adenocarcinoma, with a longer dysphagia free interval than historical controls treated with laser alone.<\/jats:p>","DOI":"10.1136\/gut.39.5.726","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"726-731","source":"Crossref","is-referenced-by-count":24,"title":["Laser and brachytherapy in the palliation of adenocarcinoma of the oesophagus and cardia."],"prefix":"10.1136","volume":"39","author":[{"given":"G M","family":"Spencer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Thorpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I R","family":"Sargeant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Blackman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Solano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Tobias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S G","family":"Bown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/bmj.304.6828.711","article-title":"Oesophageal cancer in Britain (letter)","volume":"304","author":"Cheng, K.K.; Day, N.E.","year":"1992","unstructured":"Cheng KK, Day NE. Oesophageal cancer in Britain (letter). BMJ 1992; 304: 711.","journal-title":"BMJ"},{"key":"ref_2","first-page":"167","article-title":"Therapeutic options and patient selection in the management of oesophageal carcinoma","volume-title":"Disorders of the oesophagus","author":"Watson, A.","year":"1984","unstructured":"Watson A. Therapeutic options and patient selection in the management of oesophageal carcinoma. In: Watson A, Celestin L R, eds. Disorders of the oesophagus. London: Pitman, 1984: 167-86."},{"issue":"64","key":"ref_3","first-page":"860","article-title":"Surgery for carcinoma of the oesophagus","volume":"1988","author":"Watson, A.","unstructured":"Watson A. Surgery for carcinoma of the oesophagus. PostgradMedJ7 1988; 64: 860-4.","journal-title":"PostgradMedJ7"},{"key":"ref_4","first-page":"275","article-title":"Treatment policy for management of carcinoma of the oesophagus","volume-title":"BrJ7Surg","volume":"75","author":"Desa, L.; Raghunath, A.S.; Chawla, S.L.; Peel, A.L.; Dellipiani, A.W.","year":"1988","unstructured":"Desa L, Raghunath AS, Chawla SL, Peel AL, Dellipiani AW. Treatment policy for management of carcinoma of the oesophagus. BrJ7Surg 1988; 75: 275-8."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1136\/gut.33.12.1602","article-title":"Endoscopic palliation for inoperable malignant dysphagia: long term follow up","volume":"33","author":"Maunour, V.; Brunetaud, J.M.; Cochelard, P.","year":"1992","unstructured":"Maunour V, Brunetaud JM, Cochelard P. Endoscopic palliation for inoperable malignant dysphagia: long term follow up. Gut 1992; 33: 1602-7.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1136\/gut.33.12.1597","article-title":"Radiation enhancement of laser palliation for malignant dysphagia: a pilot study","volume":"33","author":"Sargeant, I.R.; Loizou, L.A.; Tobias, J.S.; Blackman, G.; Thorpe, S.; Bown, S.G.","year":"1992","unstructured":"Sargeant IR, Loizou LA, Tobias JS, Blackman G, Thorpe S, Bown SG. Radiation enhancement of laser palliation for malignant dysphagia: a pilot study. Gut 1992; 33: 1597-601.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0016-5107(91)70775-X","article-title":"Laser versus laser plus afterloading with iridium-192 in the palliative treatment of malignant stenosis of the esophagus: a prospective, randomised and controlled study","volume":"37","author":"Sander, R.; Hagenmueller, F.; Sander, C.; Riess, G.; Classen, M.","year":"1991","unstructured":"Sander R, Hagenmueller F, Sander C, Riess G, Classen M. Laser versus laser plus afterloading with iridium-192 in the palliative treatment of malignant stenosis of the esophagus: a prospective, randomised and controlled study. Gastrointest Endosc 1991; 37: 433-40.","journal-title":"Gastrointest Endosc"},{"key":"ref_8","first-page":"334","article-title":"Present status and future potential of radiotherapy in the management of oesophageal cancer","volume-title":"Carcinoma of the oesophagus","author":"Pearson, J.G.","year":"1978","unstructured":"Pearson JG. Present status and future potential of radiotherapy in the management of oesophageal cancer. In: Silber F, ed. Carcinoma of the oesophagus. Rotterdam: Balkema, 1978: 334-9."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0167-8140(88)90188-0","article-title":"The effect of radiotherapy on dysphagia and survival in patients with oesophageal cancer","volume":"12","author":"Caspers, R.J.L.; Welvaart, K.; Verkes, J.; Hermans, J.; Leer, J.W.H.","year":"1988","unstructured":"Caspers RJL, Welvaart K, Verkes J, Hermans J, Leer JWH. The effect of radiotherapy on dysphagia and survival in patients with oesophageal cancer. Radiother Oncol 1988; 12: 15-23.","journal-title":"Radiother Oncol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0016-5107(87)71638-1","article-title":"Palliative endoscopic management of obstructive esophagogastric cancer: laser or prosthesis","volume":"33","author":"Buset, M.; des Marez, B.; Baize, M.; Bourgeois, N.; de Boelpaepe, C.; de Toeuf, J.; Cremer, M.","year":"1987","unstructured":"Buset M, des Marez B, Baize M, Bourgeois N, de Boelpaepe C, de Toeuf J, Cremer M. Palliative endoscopic management of obstructive esophagogastric cancer: laser or prosthesis. Gastrointest Endosc 1987; 33: 357-61.","journal-title":"Gastrointest Endosc"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1136\/gut.28.7.792","article-title":"Palliative laser therapy for malignant dysphagia","volume":"28","author":"Krasner, N.; Barr, H.; Skidmore, C.; Al, Morris","year":"1987","unstructured":"Krasner N, Barr H, Skidmore C, Morris Al. Palliative laser therapy for malignant dysphagia. Gut 1987; 28: 792-8.","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2007-1018404","article-title":"Palliative laser treatment of malignant stenoses in the upper gastrointestinal tract","volume":"18","author":"Ell, C.; Riemann, J.F.; Luxt, G.; Demling, L.","year":"1986","unstructured":"Ell C, Riemann JF, Luxt G, Demling L. Palliative laser treatment of malignant stenoses in the upper gastrointestinal tract. Endoscopy 1986; 18: 21-6.","journal-title":"Endoscopy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/1097-0142(19920715)70:2<386::AID-CNCR2820700203>3.0.CO;2-H","article-title":"A prospective assessment of quality of life after endoscopic intubation and laser therapy for malignant dysphagia","volume":"70","author":"Loizou, L.A.; Rampton, D.; Atikinson, M.; Robertson, C.; Bown, S.G.","year":"1992","unstructured":"Loizou LA, Rampton D, Atikinson M, Robertson C, Bown SG. A prospective assessment of quality of life after endoscopic intubation and laser therapy for malignant dysphagia. Cancer 1992; 70: 386-91.","journal-title":"Cancer"},{"article-title":"Intracavity irradiation in the palliation of carcinoma of the oesophagus and cardia. Lancet 1985; ii: 981-2. Palliation of adenocarcinoma ofoesophagus and cardia","author":"Rowland, C.G.; Pagliero, K.M.","key":"ref_14","unstructured":"Rowland CG, Pagliero KM. Intracavity irradiation in the palliation of carcinoma of the oesophagus and cardia. Lancet 1985; ii: 981-2. Palliation of adenocarcinoma ofoesophagus and cardia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0022-5223(19)34850-0","article-title":"Prospective randomised clinical trial comparing brachytherapy and laser photoablation for palliation of esophageal cancer","volume":"104","author":"Low, D.E.; Pagliero, K.M.","year":"1992","unstructured":"Low DE, Pagliero KM. Prospective randomised clinical trial comparing brachytherapy and laser photoablation for palliation of esophageal cancer. J Thorac Cardiovasc Surg 1992; 104: 173-9.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2007-1018405","article-title":"Palliative treatment of malignant stenoses of the upper gastrointestinal tract using a combination of laser and afterloading therapy","volume":"18","author":"Bader, M.; Dittler, H.J.; Ultsch, B.; Ries, G.; Siewert, JR","year":"1986","unstructured":"Bader M, Dittler HJ, Ultsch B, Ries G, Siewert JR. Palliative treatment of malignant stenoses of the upper gastrointestinal tract using a combination of laser and afterloading therapy. Endoscopy 1986; 18: 27-31.","journal-title":"Endoscopy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/gut.35.3.299","article-title":"Palliation of malignant dysphagia by ethanol induced tumour necrosis","volume":"35","author":"Nwokolo, C.U.; Payne-James, J.J.; Silk, D.B.A.; Misiewicz, J.J.; Loft, D.E.","year":"1994","unstructured":"Nwokolo CU, Payne-James JJ, Silk DBA, Misiewicz JJ, Loft DE. Palliation of malignant dysphagia by ethanol induced tumour necrosis. Gut 1994; 35: 299-303.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0016-5085(91)90782-G","article-title":"A prospective comparison of laser therapy and intubation in endoscopic palliation for malignant dysphagia","volume":"100","author":"Loizou, L.A.; Grigg, D.; Atkinson, M.; Robertson, B.; Bown, S.G.","year":"1991","unstructured":"Loizou LA, Grigg D, Atkinson M, Robertson B, Bown SG. A prospective comparison of laser therapy and intubation in endoscopic palliation for malignant dysphagia. Gastroenterology 1991; 100: 1303-10.","journal-title":"Gastroenterology"},{"issue":"57","key":"ref_19","first-page":"252","article-title":"Upper intestinal and biliary tract endoprostheses","volume":"31","author":"Tytgat, G.N.J.; Bartelsman, J.F.W.M.; Den Hartog Jager, F.C.A.; Huibregtse, K.; Mathus-Vliegen, E.M.H.","year":"1986","unstructured":"Tytgat GNJ, Bartelsman JFWM, Den Hartog Jager FCA, Huibregtse K, Mathus-Vliegen EMH. Upper intestinal and biliary tract endoprostheses. Dig Dis Sci 1986; 31: 57S-75S. 21 Barr H, Krasner N, Raouf A, Walker RJ. Prospective randomised trial of laser therapy only and laser therapy followed by endoscopic intubation for the palliation of malignant dysphagia. Gut 1990; 31: 252-8.","journal-title":"Dig Dis Sci; Prospective randomised trial of laser therapy only and laser therapy followed by endoscopic intubation for the palliation of malignant dysphagia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0009-9260(05)81831-8","article-title":"The Strecker esophageal stent in the management of oesophageal strictures: Technique of insertion and early clinical experience","volume":"49","author":"Grundy, A.","year":"1994","unstructured":"Grundy A. The Strecker esophageal stent in the management of oesophageal strictures: Technique of insertion and early clinical experience. Clin Radiol 1994; 49: 421-4.","journal-title":"Clin Radiol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJM199310283291803","article-title":"A controlled trial of an expansile metal stent for palliation of esophageal obstruction due to inoperable cancer","volume":"329","author":"Knyrim, K.; Wagner, H.J.; Bethge, N.; Keymling, M.; Vakil, N.","year":"1993","unstructured":"Knyrim K, Wagner HJ, Bethge N, Keymling M, Vakil N. A controlled trial of an expansile metal stent for palliation of esophageal obstruction due to inoperable cancer. N EnglJ3Med 1993; 329: 1302-7.","journal-title":"N EnglJ3Med"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1055\/s-2007-1005753","article-title":"Highly flexible selfexpanding meshed metal stents for palliation of malignant esophagogastric obstruction","volume":"27","author":"Grund, K.E.; Storek, D.; Becker, H.D.","year":"1995","unstructured":"Grund KE, Storek D, Becker HD. Highly flexible selfexpanding meshed metal stents for palliation of malignant esophagogastric obstruction. Endoscopy 1995; 27: 486-94.","journal-title":"Endoscopy"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1055\/s-2007-1005754","article-title":"Gianturco-Z stents in the palliative treatment of malignant esophageal obstruction and esophagotracheal fistulas","volume":"27","author":"Ell, C.; May, A.; Hahn, E.G.","year":"1995","unstructured":"Ell C, May A, Hahn EG. Gianturco-Z stents in the palliative treatment of malignant esophageal obstruction and esophagotracheal fistulas. Endoscopy 1995; 27: 495-500.","journal-title":"Endoscopy"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.39.5.726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:07:51Z","timestamp":1763744871000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.39.5.726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1996,11,1]]},"published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1136\/gut.39.5.726"],"URL":"https:\/\/doi.org\/10.1136\/gut.39.5.726","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}