{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:15:40Z","timestamp":1791281740632,"version":"4.1.0"},"reference-count":44,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1996,11,1]]},"DOI":"10.1136\/gut.39.5.741","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:41:31Z","timestamp":1190151691000},"page":"741-747","source":"Crossref","is-referenced-by-count":98,"title":["Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome."],"prefix":"10.1136","volume":"39","author":[{"given":"D","family":"Louvel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Delvaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Felez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fioramonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Lazorthes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Frexinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"480","article-title":"Evaluation of colonic myoelectric activity in health and in functional disorders","volume-title":"Gut","volume":"21","author":"Bueno, L.; Fioramonti, J.; Rukebusch, Y.; Frexinos, J.; Coulon, P.","year":"1985","unstructured":"Bueno L, Fioramonti J, Rukebusch Y, Frexinos J, Coulon P. Evaluation of colonic myoelectric activity in health and in functional disorders. Gut 1985; 21: 480-5."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1136\/gut.28.12.1613","article-title":"Colonic myoelectrical activity in IBS painless diarrhoea","volume":"28","author":"Frexinos, J.; Fioramonti, J.; Bueno, L.","year":"1987","unstructured":"Frexinos J, Fioramonti J, Bueno L. Colonic myoelectrical activity in IBS painless diarrhoea. Gut 1987; 28: 1613-8.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/BF01395503","article-title":"Irritable bowel syndrome: physiological and psychological difference between diarrhea-predominant and constipationpredominant patients","volume":"35","author":"Whitehead, W.E.; Engle, B.J.; Schuster, M.M.","year":"1980","unstructured":"Whitehead WE, Engle BJ, Schuster MM. Irritable bowel syndrome: physiological and psychological difference between diarrhea-predominant and constipationpredominant patients. Dig Dis Sci 1980; 35: 404-13.","journal-title":"Dig Dis Sci"},{"key":"ref_4","first-page":"1150","article-title":"Effect of anger on colon motor and myoelectric activity in the irritable bowel syndrome","volume":"14","author":"Welgan, P.; Meshkinpour, H.; Beeler, M.","year":"1988","unstructured":"Welgan P, Meshkinpour H, Beeler M. Effect of anger on colon motor and myoelectric activity in the irritable bowel syndrome. Gastroenterology 1988; 14: 1150-6.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/BF01540058","article-title":"Motility disorders and stress","volume":"34","author":"Camilleri, M.; Neri, M.","year":"1989","unstructured":"Camilleri M, Neri M. Motility disorders and stress. Dig Dis Sci 1989; 34: 1777-86.","journal-title":"Dig Dis Sci"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1056\/NEJM197804202981604","article-title":"Cohen 5, Snape WJ Jr. Colonic myoelectrical activity in irritable bowel syndrome. Effect of eating and anticholinergics","volume":"298","author":"Sullivan, M.A.","year":"1978","unstructured":"Sullivan MA, Cohen 5, Snape WJ Jr. Colonic myoelectrical activity in irritable bowel syndrome. Effect of eating and anticholinergics. NEnglJffMed 1978; 298: 878-83.","journal-title":"NEnglJffMed"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/0016-5085(90)90289-D","article-title":"Postprandial colonic transit and motor activity in chronic constipation","volume":"98","author":"Bazzocchi, G.; Ellis, J.; Villanueva-Meyer, J.; Jing, J.; Reddy, S.N.; Meno, I.","year":"1990","unstructured":"Bazzocchi G, Ellis J, Villanueva-Meyer J, Jing J, Reddy SN, Meno I, et al. Postprandial colonic transit and motor activity in chronic constipation. Gastroenterology 1990; 98: 686-93.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"69","article-title":"Irritable bowel syndrome. In: Cohen 5, Soloway RD, eds. Functional disorders of the gastrointestinal tract","author":"WI, Jr, Snape","year":"1987","unstructured":"Snape WI Jr. Irritable bowel syndrome. In: Cohen 5, Soloway RD, eds. Functional disorders of the gastrointestinal tract. New York: Churchill Livingstone, 1987: 69-83."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0016-5085(86)90685-2","article-title":"Abnormal sensory perception in patients with esophageal chest pain","volume":"91","author":"Richter, J.E.; Barish, C.F.; Castell, D.O.","year":"1986","unstructured":"Richter JE, Barish CF, Castell DO. Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986; 91: 845-52.","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/gut.33.5.580","article-title":"Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain","volume":"33","author":"JJ, De Caestecker; A, Pryde; RC, Hedding","year":"1992","unstructured":"De Caestecker JJ, Pryde A, Hedding RC. Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain. Gut 1992; 33: 580-6.","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF01300087","article-title":"Visceral perception in health and in functional dyspepsia. A cross-over study of gastric distension with placebo and domperidone","volume":"36","author":"Bradette, M.; Pare, P.","year":"1991","unstructured":"Bradette M, Pare P. Visceral perception in health and in functional dyspepsia. A cross-over study of gastric distension with placebo and domperidone. Dig Dis Sci 1991; 36: 52-8.","journal-title":"Dig Dis Sci"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/BF01307517","article-title":"Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia","volume":"36","author":"Lemann, M.; Dederding, J.P.; Flourie, B.; Franchiesseur, C.; Rambaud, J.C.; Jian, R.","year":"1991","unstructured":"Lemann M, Dederding JP, Flourie B, Franchiesseur C, Rambaud JC, Jian R. Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia. Dig Dis Sci 1991; 36: 1249-54.","journal-title":"Dig Dis Sci"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.14.2.125","article-title":"Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome","volume":"14","author":"Ritchie, J.","year":"1973","unstructured":"Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973; 14: 125-32.","journal-title":"Gut"},{"key":"ref_14","first-page":"443","article-title":"Site ofpain from the irritable bowel","volume":"ii:","author":"Swarbrich, E.T.; Bat, L.; HegortyJE, Williams; C.B.","year":"1980","unstructured":"Swarbrich ET, Bat L, HegortyJE, Williams CB. Site ofpain from the irritable bowel. Lancet 1980; ii: 443-6.","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0016-5085(90)90332-U","article-title":"Tolerance for rectosigmoid distension in irritable bowel syndrome","volume":"98","author":"WhiteheadWE, HoltkotterB; EnckP, Hoelzl R.; KO, Holmes; J, Anthony","year":"1990","unstructured":"WhiteheadWE, HoltkotterB, EnckP, Hoelzl R, Holmes KO, Anthony J, et al. Tolerance for rectosigmoid distension in irritable bowel syndrome. Gastroenterology 1990; 98: 1187-92.","journal-title":"Gastroenterology"},{"key":"ref_16","first-page":"163","article-title":"Mechanisms of pain in irritable bowel syndrome","volume":"1985","author":"Ritchie, J.","unstructured":"Ritchie J. Mechanisms of pain in irritable bowel syndrome. In: Read NW, ed. Irritable bowel syndrome. Philadelphia, Grune and Stratton, 1985: 163-72.","journal-title":"Philadelphia, Grune and Stratton; bowel syndrome"},{"key":"ref_17","first-page":"155","article-title":"Origin ofpain in the irritable bowel syndrome","volume":"1985","author":"Dawson, A.M.","unstructured":"Dawson AM. Origin ofpain in the irritable bowel syndrome. In: Read NW, ed. Irritable bowel syndrome. Philadelphia: Grune and Stratton, 1985: 155-62.","journal-title":"Philadelphia: Grune and Stratton; bowel syndrome"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF02088327","article-title":"Evaluation of colonic sensory thresholds in IBS patients using a barostat: definition of optimal conditions and comparison with healthy subjects","volume":"39","author":"BradetteM, DelvauxM; StaumontG, FioramontiJ; BuenoL, Frexinos J.","year":"1994","unstructured":"BradetteM, DelvauxM, StaumontG, FioramontiJ, BuenoL, Frexinos J. Evaluation of colonic sensory thresholds in IBS patients using a barostat: definition of optimal conditions and comparison with healthy subjects. Dig Dis Sci 1994; 39: 449-57.","journal-title":"Dig Dis Sci"},{"key":"ref_19","first-page":"3","article-title":"Functional bowel disorders and the visceral hyperalgesia hypothesis","volume-title":"clinical aspects of chronic abdominal pain","author":"Mayer, E.A.; Gebhart, G.F.","year":"1993","unstructured":"Mayer EA, Gebhart GF. Functional bowel disorders and the visceral hyperalgesia hypothesis. In: Mayer EA, Raybould HE, eds. Basic and clinical aspects of chronic abdominal pain. New York: Elsevier, 1993: 3-28."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/BF02093780","article-title":"Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone","volume":"39","author":"BradetteM, StaumontG; DelvauxM, FioramontiJ; BuenoL, Frexinos J.","year":"1994","unstructured":"BradetteM, StaumontG, DelvauxM, FioramontiJ, BuenoL, Frexinos J. Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone. Dig Dis Sci 1994; 39: 1171-8.","journal-title":"Dig Dis Sci"},{"key":"ref_21","first-page":"327","article-title":"Central nervous system distribution of vasopressin, oxytocin and neurophysin","volume-title":"peptides and learning and memory processes","author":"Sofroniew, M.V.; Weindl, A.","year":"1981","unstructured":"Sofroniew MV, Weindl A. Central nervous system distribution of vasopressin, oxytocin and neurophysin. In: Martinez JL, Jensen RA, Messing RB, Rigter H, McGaugh JL, eds. Endogenous peptides and learning and memory processes. New York: Academic Press, 1981: 327-69."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(93)91456-3","article-title":"Oxytocin modulates the effects of galanin in carrageenaninduced hyperalgesia in rats","volume":"608","author":"Lundeberg, T.; Meister, B.; Bjorkstrand, E.; Uvnas-Moberg, K.","year":"1993","unstructured":"Lundeberg T, Meister B, Bjorkstrand E, Uvnas-Moberg K. Oxytocin modulates the effects of galanin in carrageenaninduced hyperalgesia in rats. Brain Res 1993; 608: 181-5.","journal-title":"Brain Res"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0196-9781(84)90017-2","article-title":"Vasopressin analgesia: specificity of action and non-opioid effects","volume":"5","author":"Kordower, J.H.; Bodnar, R.J.","year":"1984","unstructured":"Kordower JH, Bodnar RJ. Vasopressin analgesia: specificity of action and non-opioid effects. Peptides 1984; 5: 747-56.","journal-title":"Peptides"},{"key":"ref_24","first-page":"93","article-title":"oxytocin and their related neurophysins","volume-title":"neuropeptides in the CNS, part 1","author":"Vasopressin, Sofroniew M.V.","year":"1985","unstructured":"Sofroniew MV. Vasopressin, oxytocin and their related neurophysins. In: Bj6rklund A, Hokfelt T, eds. GABA and neuropeptides in the CNS, part 1. Amsterdam: Elsevier, 1985: 93-165."},{"key":"ref_25","first-page":"427","article-title":"Intraventricular somatostatin-14, arginin vasopressin and oxytocin: analgesic effect in a patient with intractable cancer pain","volume":"50","author":"Madrazo, I.; Franco-Bourland, R.E.; Leon-Meza, V.M.; Mena, I.","year":"1987","unstructured":"Madrazo I, Franco-Bourland RE, Leon-Meza VM, Mena I. Intraventricular somatostatin-14, arginin vasopressin and oxytocin: analgesic effect in a patient with intractable cancer pain. JAppl Neurophysiol 1987; 50: 427-31.","journal-title":"JAppl Neurophysiol"},{"key":"ref_26","first-page":"92","article-title":"Irritable bowel syndrome: guidelines for the diagnosis","volume":"2","author":"Thompson, W.S.; Dotterval, G.; Drossman, D.A.; Heaton, K.W.; Kruis, S.W.","year":"1989","unstructured":"Thompson WS, Dotterval G, Drossman DA, Heaton KW, Kruis SW. Irritable bowel syndrome: guidelines for the diagnosis. Gastroenterol Int 1989; 2: 92-5.","journal-title":"Gastroenterol Int"},{"key":"ref_27","first-page":"347","article-title":"A multifunction and programmable computerized barostat","volume":"17","author":"Hachet, T.; Caussette, M.","year":"1993","unstructured":"Hachet T, Caussette M. A multifunction and programmable computerized barostat. Gastroenterol Clin Biol 1993; 17: 347-51.","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0304-3959(77)90036-7","article-title":"Comparative study of perceived pain and nociceptive flexion reflex in man","volume":"3","author":"Wller, J.C.","year":"1977","unstructured":"Wller JC. Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 1977; 3: 69-80.","journal-title":"Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-8993(79)90489-X","article-title":"Supraspinal influences on nociceptive flexion reflex and pain sensation in man","volume":"179","author":"Wilier, J.C.; Boureau, F.; Albe-Fessard, D.","year":"1979","unstructured":"Wilier JC, Boureau F, Albe-Fessard D. Supraspinal influences on nociceptive flexion reflex and pain sensation in man. Brain Res 1979; 179: 61-8.","journal-title":"Brain Res"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/brain\/107.4.1095","article-title":"Psychophysical and electrophysiological approaches to the pain-relieving effects of heterotopic nociceptive stimuli","volume":"107","author":"Willer, J.C.; Roby, A.; Le Bars, D.","year":"1984","unstructured":"Willer JC, Roby A, Le Bars D. Psychophysical and electrophysiological approaches to the pain-relieving effects of heterotopic nociceptive stimuli. Brain 1984; 107: 1095-112.","journal-title":"Brain"},{"key":"ref_31","first-page":"457","article-title":"Somatostatin analog inhibits sensory afferent response to rectal distension in irritable bowel patients with rectal urgency","volume":"102","author":"Hasler, W.; Soudah, H.; Owyang, C.","year":"1992","unstructured":"Hasler W, Soudah H, Owyang C. Somatostatin analog inhibits sensory afferent response to rectal distension in irritable bowel patients with rectal urgency. Gastroenterology 1992; 102: 457.","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0016-5085(95)26671-2","article-title":"The K-agonist fedotozine increases thresholds of first sensation and pain perception to colonic distension in patients with irritable bowel syndrome","volume":"108","author":"Delvaux, M.; Louvel, D.; Scherrer, B.; Fraitag, B.; Frexinos, J.","year":"1995","unstructured":"Delvaux M, Louvel D, Scherrer B, Fraitag B, Frexinos J. The K-agonist fedotozine increases thresholds of first sensation and pain perception to colonic distension in patients with irritable bowel syndrome. Gastroenterology 1995; 108: A590.","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2036.1993.tb00087.x","article-title":"Reduction of rectal sensitivity and postprandial motility by granisetron, a 5-HT3 receptor antagonist, in patients with irritable bowel syndrome","volume":"7","author":"Prior, A.; Read, N.","year":"1993","unstructured":"Prior A, Read N. Reduction of rectal sensitivity and postprandial motility by granisetron, a 5-HT3 receptor antagonist, in patients with irritable bowel syndrome. Aliment Pharnacol Ther 1993; 7: 175-80.","journal-title":"Aliment Pharnacol Ther"},{"key":"ref_34","first-page":"38","article-title":"Effect of suckling on gastric motility in lactating rats","volume":"261","author":"Helmreich, D.L.; Thiels, E.; SvedAF, VerbalisJG; StrickerEM","year":"1991","unstructured":"Helmreich DL, Thiels E, SvedAF, VerbalisJG, StrickerEM. Effect of suckling on gastric motility in lactating rats. Am J3Physiol 1991; 261: R38-43.","journal-title":"Am J3Physiol"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0196-9781(87)90017-9","article-title":"Oxytocin, oxytocin antagonist, TRH and hypothalamic paraventricular nucleus stimulation effects on gastric motility","volume":"8","author":"Rogers, R.C.; Hermann, G.E.","year":"1987","unstructured":"Rogers RC, Hermann GE. Oxytocin, oxytocin antagonist, TRH and hypothalamic paraventricular nucleus stimulation effects on gastric motility. Peptides 1987; 8: 505-13.","journal-title":"Peptides"},{"key":"ref_36","first-page":"384","article-title":"Vasopression and oxytocin in the rat spinal cord: analysis of their role in the control of nociception","volume":"309","author":"Millan, M.J.; Schmauss, C.; Millan, M.H.; Herz, A.","year":"1984","unstructured":"Millan MJ, Schmauss C, Millan MH, Herz A. Vasopression and oxytocin in the rat spinal cord: analysis of their role in the control of nociception. Brain Res 1984; 309: 384-8.","journal-title":"Brain Res"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0024-3205(80)90165-4","article-title":"Antinociceptive effects of intraventricular or systemic administration of vasopressin in the rat","volume":"26","author":"Bemtson, G.G.; Berson, B.S.","year":"1980","unstructured":"Bemtson GG, Berson BS. Antinociceptive effects of intraventricular or systemic administration of vasopressin in the rat. Life Sci 1980; 26: 455-9.","journal-title":"Life Sci"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0143-4179(93)90075-L","article-title":"Influence of oxytocin on nociception and morphine antinociception","volume":"24","author":"Arletti, R.; Benelli, A.; Bertolini, A.","year":"1993","unstructured":"Arletti R, Benelli A, Bertolini A. Influence of oxytocin on nociception and morphine antinociception. Neuropeptides 1993; 24: 125-9.","journal-title":"Neuropeptides"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/0306-4522(84)90296-3","volume":"13","author":"Yamazoe, M.; Shiosaka, S.; Shibasaki, T.; Ling, N.; Tateishi, K.; Hashimura, E.","year":"1984","unstructured":"Yamazoe M, Shiosaka S, Shibasaki T, Ling N, Tateishi K, Hashimura E, et al. Neuroscience 1984; 13: 1243-66.","journal-title":"et al. Neuroscience"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0016-5085(87)90434-3","article-title":"Patients with irritable bowel syndrome have greater pain tolerance than normal subjects","volume":"93","author":"Cook, I.J.; Van Eeden, A.; Collins, S.M.","year":"1987","unstructured":"Cook IJ, Van Eeden A, Collins SM. Patients with irritable bowel syndrome have greater pain tolerance than normal subjects. Gastroenterology 1987; 93: 727-33.","journal-title":"Gastroenterology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0028-3908(85)90026-7","article-title":"Oxytocin and a C-terminal derivate (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain","volume":"24","author":"Kovacs, G.L.; Horvath, Z.S.; Sarnyai, Z.; Faludi, M.; Telegdy, G.","year":"1985","unstructured":"Kovacs GL, Horvath ZS, Sarnyai Z, Faludi M, Telegdy G. Oxytocin and a C-terminal derivate (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain. Neuropharmacology 1985; 24: 413-9.","journal-title":"Neuropharmacology"},{"key":"ref_42","first-page":"369","article-title":"Development of morphine tolerance is under tonic control of the brain oxytocin","volume-title":"DrugAlcohol Depend","volume":"17","author":"Kovacs, G.L.; Samyai, Z.; Szabo, G.; Telegdy, G.","year":"1986","unstructured":"Kovacs GL, Samyai Z, Szabo G, Telegdy G. Development of morphine tolerance is under tonic control of the brain oxytocin. DrugAlcohol Depend 1986; 17: 369-75."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/BF02093778","article-title":"Effect of leuprolide acetate in patients with moderate to severe functional bowel disease. Double-blind, placebocontrolled study","volume":"39","author":"Mathias, JR, Clench; MH, Reeves-Darby; V.G.","year":"1994","unstructured":"Mathias JR, Clench MH, Reeves-Darby VG et al. Effect of leuprolide acetate in patients with moderate to severe functional bowel disease. Double-blind, placebocontrolled study. Dig Dis Sci 1994; 39: 1155-62.","journal-title":"Dig Dis Sci"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/BF02093779","article-title":"Effect of leuprolide acetate in patients with functional bowel disease long-term follow-up after double-blind, placebo-controlled study","volume":"39","author":"Mathias, JR, Clench; MH, Roberts; PH, Reeves-Darby; V.G.","year":"1994","unstructured":"Mathias JR, Clench MH, Roberts PH, Reeves-Darby VG. Effect of leuprolide acetate in patients with functional bowel disease long-term follow-up after double-blind, placebo-controlled study. Dig Dis Sci 1994; 39: 1163-70.","journal-title":"Dig Dis Sci"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.39.5.741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:28:50Z","timestamp":1601090930000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.39.5.741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11,1]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/gut.39.5.741","relation":{},"ISSN":["0017-5749"],"issn-type":[{"value":"0017-5749","type":"print"}],"subject":[],"published":{"date-parts":[[1996,11,1]]}}}