{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:13:54Z","timestamp":1792264434353,"version":"4.4.0"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1996,12]]},"abstract":"<jats:p>BACKGROUND AND AIMS: Laparoscopic cholecystectomy is the standard treatment for symptomatic gall stone disease. This study aimed to assess the effect of the operation on patients' symptoms. METHODS: One hundred consecutive patients undergoing laparoscopic cholecystectomy between June 1994 and June 1995 were evaluated using standard questionnaires examining demographic details, indication for laparoscopic cholecystectomy, characteristics of pain, and other associated dyspeptic and colonic symptoms. A history of psychiatric disturbances and of hysterectomy were also recorded. The same questionnaires were administered again six months after the operation. Operation notes and histological reports were reviewed. RESULTS: Three patients were converted to open surgery and were excluded from analysis. The median age of the remaining 97 patients was 50.9 (19-85) years; 19 were men. There was one complication each of bleeding and biliary leak. Indications for laparoscopic cholecystectomy were biliary type pain (66 patients) and complicated gall stone disease (acute cholecystitis 21, cholestatic jaundice six, and pancreatitis four). Thirteen patients (13%) had persistent pain and two (3%) developed diarrhoea at follow up. Only one patient with persistent pain after laparoscopic cholecystectomy originated from the complicated gall stone disease group. Logistic discriminant analysis showed that bloating (p &lt; 0.001), constipation (p &lt; 0.05), and previous and current use of psychotrophic drugs (p &lt; 0.001) were significantly more common among those with a poor outcome after laparoscopic cholecystectomy. Heartburn was unaffected. Of patients with persistent symptoms after cholecystectomy 77% had no or mild histological changes of cholecystitis as compared with 30% in the pain free group. CONCLUSIONS: The incidence of persistent pain after laparoscopic cholecystectomy was 13%. Abdominal bloating and psychiatric medications were predictive for persistence of pain after laparoscopic cholecystectomy.<\/jats:p>","DOI":"10.1136\/gut.39.6.863","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"863-866","source":"Crossref","is-referenced-by-count":73,"title":["Incidence of persistent symptoms after laparoscopic cholecystectomy: a prospective study."],"prefix":"10.1136","volume":"39","author":[{"given":"W","family":"Luman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W H","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S N","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I M","family":"Mcintyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Hamer-Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K R","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1996,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/bjs.1800780209","article-title":"Reduced postoperative hospitalization after laporoscopic cholecystecomy","volume":"78","author":"Grace, P.A.; Qureshi, A.; Coleman, J.E.","year":"1991","unstructured":"Grace PA, Qureshi A, Coleman JE. Reduced postoperative hospitalization after laporoscopic cholecystecomy. Br Jf Surg 1991; 78: 160-2.","journal-title":"Br Jf Surg"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/bjs.1800780208","article-title":"Laporoscopic cholecystectomy: the Dundee technique","volume":"78","author":"Nathanson, L.K.; Shimi, S.; Cushieri, A.","year":"1991","unstructured":"Nathanson LK, Shimi S, Cushieri A. Laporoscopic cholecystectomy: the Dundee technique. BrJ Surg 1991; 78: 155-9.","journal-title":"BrJ Surg"},{"key":"ref_3","first-page":"552","article-title":"Laporoscopic cholecystectomy","volume-title":"BrJSurg","volume":"80","author":"Macintyre, I.M.C.; Wilson, R.G.","year":"1993","unstructured":"Macintyre IMC, Wilson RG. Laporoscopic cholecystectomy. BrJSurg 1993; 80: 552-9."},{"key":"ref_4","first-page":"349","article-title":"Postcholecystectomy symptoms after laporoscopic cholecystectomy","volume":"75","author":"Qureshi, M.A.; Brindley, N.M.; Osborne, D.H.","year":"1993","unstructured":"Qureshi MA, Brindley NM, Osborne DH, et al. Postcholecystectomy symptoms after laporoscopic cholecystectomy. Ann R Coll Surg Engl 1993; 75: 349-53.","journal-title":"Ann R Coll Surg Engl"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00000658-199101000-00002","article-title":"Safety and efficacy of laporoscopic cholecystectomy. A prospective analysis of 100 initial patients","volume":"213","author":"Peters, J.H.; Ellison, C.; Innes, J.E.","year":"1991","unstructured":"Peters JH, Ellison C, Innes JE. Safety and efficacy of laporoscopic cholecystectomy. A prospective analysis of 100 initial patients. Ann Surg 1991; 213: 3-12.","journal-title":"Ann Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/bjs.1800800410","article-title":"Symptomatic outcome after laporoscopic cholecystectomy","volume":"89","author":"Wilson, R.G.; MacIntyre, I.M.","year":"1993","unstructured":"Wilson RG, MacIntyre IM. Symptomatic outcome after laporoscopic cholecystectomy. Br Jf Surg 1993; 89: 439-41.","journal-title":"Br Jf Surg"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/gut.34.10.1448","article-title":"Outcome after cholecystectomy for symptomatic gall stone disease and effect of surgical access: laparoscopic v open approach","volume":"34","author":"Velpen, G.C.V.; Shimi, S.M.; Cushieri, A.","year":"1993","unstructured":"Velpen GCV, Shimi SM, Cushieri A. Outcome after cholecystectomy for symptomatic gall stone disease and effect of surgical access: laparoscopic v open approach. Gut 1993; 34: 1448-51.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1136\/gut.28.11.1500","article-title":"Postcholecystectomy symptoms. A prospective study of gall stone patients before and two years after surgery","volume":"28","author":"Ros, E.; Zambon, D.","year":"1987","unstructured":"Ros E, Zambon D. Postcholecystectomy symptoms. A prospective study of gall stone patients before and two years after surgery. Gut 1987; 28: 1500-4.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/bjs.1800800132","article-title":"Long-term follow-up after open cholecystectomy","volume":"80","author":"Kinsten, J.; Gouma, D.J.; von Meyenfeldt, M.F.; Menheere, P.","year":"1993","unstructured":"Kinsten J, Gouma DJ, von Meyenfeldt MF, Menheere P. Long-term follow-up after open cholecystectomy. Br J Surg 1993; 80: 100-2.","journal-title":"Br J Surg"},{"key":"ref_10","first-page":"39","article-title":"Modern standards for comparison of cholecystectomy with alternative treatments for symptomatic cholelithiasis with emphasis on long term relief of symptoms","volume":"170","author":"Gilliland, T.M.; Traverso, L.W.","year":"1990","unstructured":"Gilliland TM, Traverso LW. Modern standards for comparison of cholecystectomy with alternative treatments for symptomatic cholelithiasis with emphasis on long term relief of symptoms. Surg Gynaecol Obstet 1990; 170: 39-44.","journal-title":"Surg Gynaecol Obstet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/bjs.1800821028","article-title":"Symptomatic outcome 1 year after laparoscopic and minilaparotomy cholecystectomy: a randomised trial","volume":"82","author":"McMahon, A.J.; Ross, S.; Baxter, J.N.","year":"1995","unstructured":"McMahon AJ, Ross S, Baxter JN, et al. Symptomatic outcome 1 year after laparoscopic and minilaparotomy cholecystectomy: a randomised trial. BrJ Surg 1995; 82: 1378-82.","journal-title":"BrJ Surg"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3109\/00365529509089784","article-title":"Life events and stress in patients with functional dyspepsia compared with patients with duodenal ulcer and healthy controls","volume":"30","author":"T, Tangen Haug; I, Wilhelmsen; A, Besrtad; H, Ursin","year":"1995","unstructured":"Tangen Haug T, Wilhelmsen I, Besrtad A, Ursin H. Life events and stress in patients with functional dyspepsia compared with patients with duodenal ulcer and healthy controls. ScandJ Gastroenterol 1995; 30: 524-30.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1136\/gut.38.2.282","article-title":"Increased cholecystectomy rate after the introduction of laparoscopic cholecystectomy in Scotland","volume":"38","author":"Lam, C.M.; Murray, F.E.; Cuschieri, A.","year":"1996","unstructured":"Lam CM, Murray FE, Cuschieri A. Increased cholecystectomy rate after the introduction of laparoscopic cholecystectomy in Scotland. Gut 1996; 38: 282-4.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.39.6.863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:09:55Z","timestamp":1765631395000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.39.6.863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1996,12,1]]},"published-print":{"date-parts":[[1996,12]]}},"alternative-id":["10.1136\/gut.39.6.863"],"URL":"https:\/\/doi.org\/10.1136\/gut.39.6.863","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}