{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:18:11Z","timestamp":1765603091104,"version":"3.48.0"},"reference-count":1,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1963,3]]},"abstract":"<jats:p>The gastric secretory response of dogs with fundal pouches to insulin hypoglycaemia is biphasic in character, the two secretory peaks being separated by some hours. The first response depends on the intact innervation of the pouch and is attributed to direct vagal action on the parietal cell. Experiments have been made to test the hypothesis that the second peak is due to activation of a pituitary adrenal mechanism.<\/jats:p>\n                  <jats:p>The second phasic response does not depend on the intact innervation of the pouch and does not coincide with the period of hypoglycaemia. No relationship has been established with the second phase and plasma cortisol levels nor is this peak abolished by bilateral adrenalectomy. The second acid secretory response, however, is only evident when acid secretion of the main stomach makes prolonged contact with the antral mucosa; it is abolished by antrectomy. The hypothesis is put forward that the pattern of response following insulin hypoglycaemia after the initial vagal response is attributable to an interaction of acid-inhibiting and acid-stimulating mechanisms of gastric acid secretion mediated through the gastric antrum.<\/jats:p>","DOI":"10.1136\/gut.4.1.42","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"42-47","source":"Crossref","is-referenced-by-count":21,"title":["Studies in dogs on the biphasic nature of the gastric secretory response to hypoglycaemia and other stimuli with special reference to the role of the adrenals"],"prefix":"10.1136","volume":"4","author":[{"given":"W.","family":"Sircus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. W.","family":"Huston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Preshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bass\u00f6e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Harkness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1963,3,1]]},"reference":[{"key":"ref_1","article-title":"The pattern of the biphasic response and the relation to gastric innervation and to hypoglycaemia It has been reported that electrode stimulation of the anterior hypothalamus in monkeys results in an immediate secretion of gastric juice which can be prevented by prior vagotomy. Stimulation of the posterior hypothalamus, however, is followed by gastric secretion after a delay of some hours and this delayed response is abolished by prior bilateral adrenalectomy","volume-title":"As an explanation of the latter observations these authors postulated a pituitary-adrenal phase of gastric secretion. In an extension of the study, the injection of insulin was used to stimulate gastric","year":"1953","unstructured":"The pattern of the biphasic response and the relation to gastric innervation and to hypoglycaemia It has been reported that electrode stimulation of the anterior hypothalamus in monkeys results in an immediate secretion of gastric juice which can be prevented by prior vagotomy. Stimulation of the posterior hypothalamus, however, is followed by gastric secretion after a delay of some hours and this delayed response is abolished by prior bilateral adrenalectomy (Porter, Movius, and French, 1953). As an explanation of the latter observations these authors postulated a pituitary-adrenal phase of gastric secretion. In an extension of the study, the injection of insulin was used to stimulate gastric"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.4.1.42","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:15:48Z","timestamp":1765602948000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.4.1.42"}},"subtitle":["<i>1<\/i>\n                    The pattern of the biphasic response and the relation to gastric innervation and to hypoglycaemia"],"short-title":[],"issued":{"date-parts":[[1963,3]]},"references-count":1,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1963,3,1]]},"published-print":{"date-parts":[[1963,3]]}},"alternative-id":["10.1136\/gut.4.1.42"],"URL":"https:\/\/doi.org\/10.1136\/gut.4.1.42","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1963,3]]}}}