{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:46:30Z","timestamp":1765626390287,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1963,9]]},"abstract":"<jats:p>\n                    The effect of a whole pancreas preparation (Viokase) has been investigated in 11 patients with pancreatic steatorrhoea and in five patients with steatorrhoea due to other causes. The appearance of the stool, faecal fat, and stool and blood radioactivity after a given dose of I\n                    <jats:sup>131<\/jats:sup>\n                    triolein (Raolein) were employed in assessing the response to Viokase therapy. Pancreatic steatorrhoea was considerably improved in the majority of patients, and showed some improvement in the remainder. Viokase appeared to be of limited value in the treatment of post-gastrectomy steatorrhoea, and failed to influence fat absorption in steatorrhoea due to disorder of the small intestine.\n                  <\/jats:p>","DOI":"10.1136\/gut.4.3.217","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"217-222","source":"Crossref","is-referenced-by-count":17,"title":["Pancreatic replacement therapy in the treatment of pancreatic steatorrhoea"],"prefix":"10.1136","volume":"4","author":[{"given":"I. N.","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn M.","family":"Airth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1963,9,1]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Collective review. Nutrition following total gastrectomy, with particular reference to fat and protein assimilation","volume":"95","author":"Everson, T.C.","year":"1952","unstructured":"Everson, T. C. (1952). Collective review. Nutrition following total gastrectomy, with particular reference to fat and protein assimilation. Int. Abstr. Surg., 95, 209-230.","journal-title":"Int. Abstr. Surg"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0016-5085(58)80033-5","article-title":"The radio-iodinated triolein test for steatorrhoea","volume":"34","author":"Grossman, M.I.; Jordan, Jr, P.H.","year":"1958","unstructured":"Grossman, M. I., and Jordan, P. H, Jr. (1958). The radio-iodinated triolein test for steatorrhoea. Gastroenterology, 34, 892-900.","journal-title":"Gastroenterology"},{"key":"ref_3","first-page":"215","article-title":"Effect of intestinal hormones on I13l triolein absorption in subtotal gastrectomy patients and intubated normal persons","volume":"41","author":"Johnson, J.H.; Horswell, R.R.; Tyor, M.P.; Owen, E.E.; Ruffin, J.M.","year":"1961","unstructured":"Johnson, J. H., Horswell, R. R., Tyor, M. P., Owen, E. E., and Ruffin, J. M. (1961). Effect of intestinal hormones on I13l triolein absorption in subtotal gastrectomy patients and intubated normal persons. Ibid., 41, 215-219.","journal-title":"Ibid"},{"key":"ref_4","first-page":"\"871","article-title":"Pancreaticoduodenectomy for chronic relapsing pancreatitis. Metabolic effects created by total and subtotal ablations","volume":"74","author":"Jordan, P. H. Jr.; Grossman, M. I","year":"1957","unstructured":"Jordan, P. H. Jr., and Grossman, M. I. (1957). Pancreaticoduodenectomy for chronic relapsing pancreatitis. Metabolic effects created by total and subtotal ablations. A.M.A. Arch. Surg., 74, 871-880. -. (1959). Effect of dosage schedule on the efficacy of substitutiontherapy in pancreaticinsufficiency.Gastroenterology, 36, 447-451.","journal-title":"Arch. Surg; Effect of dosage schedule on the efficacy of substitutiontherapy in pancreaticinsufficiency"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00000658-195610000-00011","article-title":"Experience with resection of the pancreas in the treatment of chronic relapsing pancreatitis","volume":"144","year":"1956","unstructured":"Longmire, W. P. Jr., Jordan, P. H. Jr., and Briggs, J. D. (1956). Experience with resection of the pancreas in the treatment of chronic relapsing pancreatitis. Ann. Surg., 144, 681-695.","journal-title":"Ann. Surg"},{"key":"ref_6","first-page":"431","article-title":"The diagnosis of pancreatic disease, with special reference to a test of pancreatic secretion utilizing both secretin and pancreozymin stimulation","volume":"27","author":"Marks, I.N.; Tompsett, S.L.","year":"1958","unstructured":"Marks, I. N., and Tompsett, S. L. (1958). The diagnosis of pancreatic disease, with special reference to a test of pancreatic secretion utilizing both secretin and pancreozymin stimulation. Quart. J. Med., 27, 431-461.","journal-title":"Quart. J. Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.7326\/0003-4819-52-6-1195","article-title":"131-labelled fat and pancreatin as a differential absorption test in patients with steatorrhoea","volume":"52","author":"Polachek, A.A.; Williard, R.F.","year":"1960","unstructured":"Polachek, A. A., and Williard, R. F. (1960). 131-labelled fat and pancreatin as a differential absorption test in patients with steatorrhoea. Ann. intern Med., 52, 1195-1200.","journal-title":"Ann. intern Med"},{"key":"ref_8","first-page":"197","article-title":"Metabolic studies in patients with cancer of the gastro-intestinal tract; VI. Disorders in alimentary digestion and absorption in patients who have undergone total gastrectomy for carcinoma of stomach","volume":"14","author":"Rekers, P.E.; Pack, G.T.; Rhoads, C.P.","year":"1943","unstructured":"Rekers, P. E., Pack, G. T., and Rhoads, C. P. (1943). Metabolic studies in patients with cancer of the gastro-intestinal tract; VI. Disorders in alimentary digestion and absorption in patients who have undergone total gastrectomy for carcinoma of stomach. Surgery, 14, 197-215.","journal-title":"Surgery"},{"key":"ref_9","first-page":"671","article-title":"Metabolism in surgical patients. III. Effect of drugs and dietary procedures on fat and nitrogen metabolism in totally gastrectomized patients","volume":"40","year":"1956","unstructured":"Schwartz, M. K., Bodansky, 0., and Randall, H. T. (1956). Metabolism in surgical patients. III. Effect of drugs and dietary procedures on fat and nitrogen metabolism in totally gastrectomized patients. Ibid., 40, 671-677.","journal-title":"Ibid"},{"key":"ref_10","first-page":"12","article-title":"Studies on postgastrectomy steatorrhoea using radioactive triolein and oleic acid","volume":"42","author":"Shingleton, W.W.; Isley, J.K.; Floyd, R.D.; Sanders, A.P.; Baylin, G.J.; Postlethwait, R.W.; Ruffin, J.M.","year":"1957","unstructured":"Shingleton, W. W., Isley, J. K., Floyd, R. D., Sanders, A. P., Baylin, G. J., Postlethwait, R. W., and Ruffin, J. M. (1957). Studies on postgastrectomy steatorrhoea using radioactive triolein and oleic acid. Ibid., 42, 12-21.","journal-title":"Ibid"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0021-9258(18)57092-7","article-title":"Rapid method for the determination of fat in the faeces","volume":"177","author":"van de Kamer, J.H.; Huinink, H.ten B.; Weijers, H.A.","year":"1949","unstructured":"van de Kamer, J. H., Huinink, H. ten B., and Weijers, H. A. (1949). Rapid method for the determination of fat in the faeces. J. Biol. Chem., 177, 347-355.","journal-title":"J. Biol. Chem"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.4.3.217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:43:46Z","timestamp":1765626226000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.4.3.217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,9]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1963,9,1]]},"published-print":{"date-parts":[[1963,9]]}},"alternative-id":["10.1136\/gut.4.3.217"],"URL":"https:\/\/doi.org\/10.1136\/gut.4.3.217","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1963,9]]}}}