{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:05:17Z","timestamp":1790726717688,"version":"4.1.0"},"reference-count":58,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,2,20]]},"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is a human pathogen that colonises the gastric mucosa and causes permanent gastric inflammation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To assess the symptoms of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection in an adult unselected population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Subjects<\/jats:italic>\n                    \u2014A random sample of 3589 adult Danes who were examined in 1982 and 1987 (n=2987).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Abdominal symptoms within the preceding year were recorded at both attendances. Circulating IgG antibodies against\n                    <jats:italic>H pylori<\/jats:italic>\n                    in serum samples drawn in 1982 were measured by using in-house indirect enzyme linked immunosorbent assays (ELISA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014People with increased levels of IgG antibodies to\n                    <jats:italic>H pylori<\/jats:italic>\n                    were more likely than uninfected individuals to report heartburn (odds ratio (OR) = 1.26, 95% confidence interval (CI) 1.03\u20131.54) and abdominal pain characterised by daily length (OR = 1.33, 95% CI 0.92\u20131.91), nocturnal occurrence (OR = 1.62, 95% CI 1.19\u20132.19), spring aggravation (OR = 1.68, 95% CI 0.70\u20134.05), and no relation to meals (OR = 0.62, 95% CI 0.43\u20130.91) or stress (OR = 0.69, 95% CI 0.50\u20130.95). The inclusion of people with increased levels of IgG antibodies to\n                    <jats:italic>H pylori<\/jats:italic>\n                    , but without upper dyspepsia, at study entry significantly increased the likelihood of reporting upper dyspepsia at follow up (OR = 1.71, 95% CI 1.24\u20132.36). People with epigastric pain and increased levels of IgM antibodies to\n                    <jats:italic>H pylori<\/jats:italic>\n                    only indicative of acute\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection were more likely to report nocturnal pain, heartburn, nausea, and vomiting.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection may precede the development of dyspepsia and is associated with a variety of gastrointestinal symptoms in people with no history of peptic ulcer disease.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.2.169","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"169-176","source":"Crossref","is-referenced-by-count":65,"title":["Relation between\n                    <i>Helicobacter pylori<\/i>\n                    infection and gastrointestinal symptoms and syndromes"],"prefix":"10.1136","volume":"41","author":[{"given":"S","family":"Rosenstock","sequence":"first","affiliation":[{"name":"aDepartment of Surgery K, Bispebjerg University Hospital, Copenhagen, Denmark, \n\nbGlostrup University Hospital, Glostrup, Denmark, \n\ncNational University Hospital, Copenhagen, Denmark, \n\ndBispebjerg University Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kay","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery K, Bispebjerg University Hospital, Copenhagen, Denmark, \n\nbGlostrup University Hospital, Glostrup, Denmark, \n\ncNational University Hospital, Copenhagen, Denmark, \n\ndBispebjerg University Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Rosenstock","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery K, Bispebjerg University Hospital, Copenhagen, Denmark, \n\nbGlostrup University Hospital, Glostrup, Denmark, \n\ncNational University Hospital, Copenhagen, Denmark, \n\ndBispebjerg University Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L P","family":"Andersen","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery K, Bispebjerg University Hospital, Copenhagen, Denmark, \n\nbGlostrup University Hospital, Glostrup, Denmark, \n\ncNational University Hospital, Copenhagen, Denmark, \n\ndBispebjerg University Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Bonnevie","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery K, Bispebjerg University Hospital, Copenhagen, Denmark, \n\nbGlostrup University Hospital, Glostrup, Denmark, \n\ncNational University Hospital, Copenhagen, Denmark, \n\ndBispebjerg University Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery K, Bispebjerg University Hospital, Copenhagen, Denmark, \n\nbGlostrup University Hospital, Glostrup, Denmark, \n\ncNational University Hospital, Copenhagen, Denmark, \n\ndBispebjerg University Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"2025121223264039000_41.2.169.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.11.1415"},{"key":"2025121223264039000_41.2.169.2","first-page":"192","article-title":"Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH.","volume":"82","author":"Morris","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"2025121223264039000_41.2.169.3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5694\/j.1326-5377.1985.tb113443.x","article-title":"Attempt to fulfil Koch\u2019s postulates for pyloric campylobacter.","volume":"142","author":"Marshall","year":"1985","journal-title":"Med J Aust"},{"key":"2025121223264039000_41.2.169.4","doi-asserted-by":"crossref","unstructured":"Tytgat GNJ, Noach LA, Rauws EAJ. 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