{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:39Z","timestamp":1772168919597,"version":"3.50.1"},"reference-count":0,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p><jats:italic>Background\/Aims<\/jats:italic><jats:italic>\u2014<\/jats:italic>To investigate the effect of the new <jats:italic>Helicobacter pylori<\/jats:italic> eradication regimen, ranitidine bismuth citrate (RBC) and clarithromycin (CLAR) dual therapy, on duodenal ulcer healing and absence of ulcer recurrence during 24 weeks follow up (overall success).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>\u2014Two hundred and thirty two <jats:italic>H pylori<\/jats:italic> positive patients with active duodenal ulcer received four weeks treatment with RBC 400 mg twice daily alone (RBC400) (n=82), or RBC 400 or 800 mg twice daily co-prescribed with clarithromycin 250 mg four times daily for 14 days, followed by 14 days of RBC 400 mg twice daily alone (RBC400+CLAR and RBC 800+CLAR, respectively, n=75 for each).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>\u2014The co-prescription regimens gave high<jats:italic>H pylori <\/jats:italic>eradication rates determined using two tests (CLOtest and <jats:sup>13<\/jats:sup>C-urea breath test) for the presence of the organism. These rates were 92% and 81% for RBC400+CLAR (n=62) and RBC800+CLAR (n=63) respectively, compared with 2% for RBC400 (n=66) (p&lt;0.001). With respect to overall success as estimated by life table analysis, RBC400+CLAR (89%) and RBC800+ CLAR (87%) were significantly more effective than RBC400 alone (51%) (p&lt;0.001). All regimens were safe and well tolerated. Trough plasma bismuth concentrations at week 4 were low (treatment medians less than 6.6\u2009ng bismuth\/ml).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>\u2014Ranitidine bismuth citrate is a well tolerated and efficacious ulcer healing drug which, when co-prescribed with clarithromycin, affords effective <jats:italic>H pylori<\/jats:italic>eradication therapy and prevents ulcer relapse in most patients with duodenal ulcer.<\/jats:p>","DOI":"10.1136\/gut.41.2.181","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T16:46:12Z","timestamp":1277916372000},"page":"181-186","source":"Crossref","is-referenced-by-count":25,"title":["Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer"],"prefix":"10.1136","volume":"41","author":[{"given":"K D","family":"Bardhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Dallaire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Eisold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,8,1]]},"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.41.2.181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:31:08Z","timestamp":1601091068000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.41.2.181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1997,8,1]]},"published-print":{"date-parts":[[1997,8,1]]}},"alternative-id":["10.1136\/gut.41.2.181"],"URL":"https:\/\/doi.org\/10.1136\/gut.41.2.181","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8,1]]}}}