{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:35:08Z","timestamp":1784223308787,"version":"3.55.0"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,4,10]]},"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Barrett\u2019s oesophagus is acquired by severe gastro-oesophageal reflux and is a premalignant condition. Acid suppression or anti-reflux surgery alone do not cause significant regression of the metaplastic mucosa nor reduce the malignant potential. Recent reports have suggested that the combination of mucosal ablation with acid suppression may result in squamous regeneration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To destroy Barrett\u2019s mucosa by thermal ablation (in the setting of acid suppression) and so induce squamous regeneration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients<\/jats:italic>\n                    \u2014Sixteen patients with non-dysplastic Barrett\u2019s oesophagus were recruited from a surveillance programme. All had been on a proton pump inhibitor.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014At intervals, non-circumferential areas of columnar mucosa were ablated using the KTP laser. Acid suppression was obtained with 40\u2009mg omeprazole daily. Multiple biopsy specimens were obtained for histological examination from ablated areas.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Ablation of all areas of glandular mucosa resulted in squamous regeneration. The number of treatments required depended on the length of the Barrett\u2019s segment. In 11 patients there was evidence of squamous regeneration over remaining Barrett\u2019s glands (in some of the post-treatment biopsy specimens) whilst in nine patients squamous metaplasia was seen within Barrett\u2019s glands.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014Mucosal ablation of Barrett\u2019s oesophagus by laser, in the setting of acid suppression, results in squamous regeneration (though some burying of Barrett\u2019s glands did occur).\n                  <\/jats:p>","DOI":"10.1136\/gut.41.3.281","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"281-284","source":"Crossref","is-referenced-by-count":129,"title":["Photothermal laser ablation of Barrett\u2019s oesophagus: endoscopic and histological evidence of squamous re-epithelialisation"],"prefix":"10.1136","volume":"41","author":[{"given":"C P","family":"Barham","sequence":"first","affiliation":[{"name":"Gloucester Gastroenterology Group, Gloucestershire Royal and Cranfield University Institute of Medical Sciences, Gloucestershire Royal Hospital, Gloucester GL1 3NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R L","family":"Jones","sequence":"additional","affiliation":[{"name":"Gloucester Gastroenterology Group, Gloucestershire Royal and Cranfield University Institute of Medical Sciences, Gloucestershire Royal Hospital, Gloucester GL1 3NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L R","family":"Biddlestone","sequence":"additional","affiliation":[{"name":"Gloucester Gastroenterology Group, Gloucestershire Royal and Cranfield University Institute of Medical Sciences, Gloucestershire Royal Hospital, Gloucester GL1 3NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"Hardwick","sequence":"additional","affiliation":[{"name":"Gloucester Gastroenterology Group, Gloucestershire Royal and Cranfield University Institute of Medical Sciences, Gloucestershire Royal Hospital, Gloucester GL1 3NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N A","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Gloucester Gastroenterology Group, Gloucestershire Royal and Cranfield University Institute of Medical Sciences, Gloucestershire Royal Hospital, Gloucester GL1 3NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Barr","sequence":"additional","affiliation":[{"name":"Gloucester Gastroenterology Group, Gloucestershire Royal and Cranfield University Institute of Medical Sciences, Gloucestershire Royal Hospital, Gloucester GL1 3NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"2025121302272074000_41.3.281.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"2025121302272074000_41.3.281.2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(84)90090-8","article-title":"Adenocarcinoma and Barrett\u2019s esophagus: an overrated risk?","volume":"87","author":"Spechler","year":"1984","journal-title":"Gastroenterology"},{"key":"2025121302272074000_41.3.281.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510033131404"},{"key":"2025121302272074000_41.3.281.4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0300-2977(95)00005-8","article-title":"Early detection and treatment of oesophageal and gastric cancer. The Rotterdam oesophageal tumour study group.","volume":"47","author":"Sievsema","year":"1995","journal-title":"Neth J Med"},{"key":"2025121302272074000_41.3.281.5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/bjc.1995.84","article-title":"Oesophageal and gastric cancer in Scotland 1960\u20131990.","volume":"71","author":"Mckinney","year":"1995","journal-title":"Br J Cancer"},{"key":"2025121302272074000_41.3.281.6","first-page":"220","article-title":"Barrett\u2019s esophagus: what\u2019s new and what to do?","volume":"84","author":"Spechler","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"2025121302272074000_41.3.281.7","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1984.01390170059012"},{"key":"2025121302272074000_41.3.281.8","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(90)90298-K"},{"key":"2025121302272074000_41.3.281.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537229"},{"key":"2025121302272074000_41.3.281.10","unstructured":"Castell DO (1985) Medical management of the patient with Barrett\u2019s esophagus. in Barrett\u2019s esophagus: pathophysiology, diagnosis and management. eds Spechler SJ Goyal RK (Elsevier Science, New York), pp 199\u2013209."},{"key":"2025121302272074000_41.3.281.11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2036.1993.tb00143.x","article-title":"The regression of columnar lined (Barrett\u2019s) oesophagus with continuous omeprazole therapy.","volume":"7","author":"Gore","year":"1993","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121302272074000_41.3.281.12","first-page":"A157","article-title":"Effect of 12 months of a proton pump inhibitor (Lansoprazole) on Barrett\u2019s esophagus: a randomized trial [abstract].","volume":"102","author":"Sampliner","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121302272074000_41.3.281.13","first-page":"A924","article-title":"Reversal of experimental Barrett\u2019s esophagus by endoscopic laser ablation and reduction of acid reflux [abstract].","volume":"102","author":"Fink","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121302272074000_41.3.281.14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307557"},{"key":"2025121302272074000_41.3.281.15","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/0016-5085(93)90646-T","article-title":"Restoration of squamous mucosa after ablation of Barrett\u2019s esophageal epithelium.","volume":"104","author":"Berenson","year":"1993","journal-title":"Gastroenterology"},{"key":"2025121302272074000_41.3.281.16","first-page":"A221","article-title":"Thermal imaging to compare three lasers for the photodestruction of superficial tissue in columnar lined oesophagus [abstract].","volume":"9","author":"Dix","year":"1994","journal-title":"Lasers Med Sci"},{"key":"2025121302272074000_41.3.281.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03054-1"},{"key":"2025121302272074000_41.3.281.18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/ssu.2980110508","article-title":"Photodynamic therapy in Barrett\u2019s esophagus: reduction of specialized mucosa, ablation of dysplasia and treatment of superficial esophageal cancer.","volume":"11","author":"Overholt","year":"1995","journal-title":"Semin Surg Oncol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.41.3.281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:27:31Z","timestamp":1765621651000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.41.3.281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9,1]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1997,9,1]]},"published-print":{"date-parts":[[1997,9,1]]}},"alternative-id":["10.1136\/gut.41.3.281"],"URL":"https:\/\/doi.org\/10.1136\/gut.41.3.281","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9,1]]}}}