{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:20:11Z","timestamp":1767666011833,"version":"3.48.0"},"reference-count":33,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,5,12]]},"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Barrett\u2019s metaplasia is a premalignant condition for which screening is recommended.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims\/methods<\/jats:italic>\n                    \u2014Annual screening endoscopies have been performed on all subjects suitable for surgery for many years. To examine the benefits to patients of continuing this policy 10 years\u2019 experience of screening for Barrett\u2019s oesophagus was reviewed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Of the 29\u2009374 endoscopies performed over this period, Barrett\u2019s metaplasia was present in 1.4%. There was an approximate equal sex distribution with the majority of cases being identified in patients over 50 years old. Thirty five per cent of these patients were suitable to enter a yearly screening programme. During screening, the length of oesophagus involved did not vary over time. As a result of 379 endoscopies performed for screening purposes, only one patient was identified as developing carcinoma solely as a result of the screening programme. Two further patients had carcinoma identified as a result of progressive dysphagia requiring additional endoscopies. All three patients who developed carcinoma while in the screening programme had \u201clong segment\u201d (&gt;8\u2009cm) regions of Barrett\u2019s metaplasia with a stricture present at the initial endoscopy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014The poor yield from this screening programme suggests that the policy should be reconsidered. Resources may be better spent on focusing on patients who present with ulceration or stricture in addition to Barrett\u2019s metaplasia.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.3.303","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"303-307","source":"Crossref","is-referenced-by-count":37,"title":["Ten years\u2019 experience of screening patients with Barrett\u2019s oesophagus in a university teaching hospital"],"prefix":"10.1136","volume":"41","author":[{"given":"C E","family":"Macdonald","sequence":"first","affiliation":[{"name":"aUniversity Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK, \n\nbDepartment of Gastroenterology, Leicester General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Wicks","sequence":"additional","affiliation":[{"name":"aUniversity Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK, \n\nbDepartment of Gastroenterology, Leicester General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Playford","sequence":"additional","affiliation":[{"name":"aUniversity Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK, \n\nbDepartment of Gastroenterology, Leicester General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"2025121313323367000_41.3.303.1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003815005"},{"key":"2025121313323367000_41.3.303.2","unstructured":"Rubin CE Haggitt RC Levine DS (1991) Endoscopic mucosal biopsy. in Textbook of gastroenterology. ed Yamada T (JB Lippincott, Philadelphia), pp 2479\u20132523."},{"key":"2025121313323367000_41.3.303.3","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.agast960614"},{"key":"2025121313323367000_41.3.303.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01354551"},{"key":"2025121313323367000_41.3.303.5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/00008469-199206000-00008","article-title":"Barrett\u2019s oesophagus.","volume":"1","author":"Bartlesman","year":"1992","journal-title":"Eur J Cancer Prev"},{"key":"2025121313323367000_41.3.303.6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1994.01420300051007"},{"key":"2025121313323367000_41.3.303.7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308357"},{"key":"2025121313323367000_41.3.303.8","first-page":"1507","article-title":"The prevalance and clinical characteristics of short segments of specialised intestinal metaplasia in the distal esophagus on routine endoscopy.","volume":"91","author":"Johnston","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025121313323367000_41.3.303.9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930815)72:4<1155::AID-CNCR2820720404>3.0.CO;2-C"},{"key":"2025121313323367000_41.3.303.10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00008469-199206000-00009","article-title":"The early diagnosis of oesophageal adenocarcinoma by endoscopic screening.","volume":"1","author":"Atkinson","year":"1992","journal-title":"Eur J Cancer Prev"},{"key":"2025121313323367000_41.3.303.11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-5223(19)34219-9","article-title":"Endoscopic surveillance of Barrett\u2019s esophagus. Does it help?","volume":"105","author":"Streitz","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025121313323367000_41.3.303.12","first-page":"670","article-title":"A guide for surveillance of patients with Barrett\u2019s esophagus.","volume":"89","author":"Provenzale","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025121313323367000_41.3.303.13","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(84)90090-8","article-title":"Adenocarcinoma and Barrett\u2019s esophagus. An overrated risk?","volume":"87","author":"Spechler","year":"1984","journal-title":"Gastroenterology"},{"key":"2025121313323367000_41.3.303.14","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.6.727"},{"key":"2025121313323367000_41.3.303.15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.9.1155"},{"key":"2025121313323367000_41.3.303.16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.4.574"},{"key":"2025121313323367000_41.3.303.17","first-page":"853","article-title":"Early detection of neoplasia of the esophagus and gastroesophageal junction.","volume":"91","author":"Riddell","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025121313323367000_41.3.303.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510033131404"},{"key":"2025121313323367000_41.3.303.19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.1.14"},{"key":"2025121313323367000_41.3.303.20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"2025121313323367000_41.3.303.21","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/0016-5085(90)90607-3","article-title":"Prevalance of columnar-lined (Barrett\u2019s) esophagus.","volume":"99","author":"Cameron","year":"1990","journal-title":"Gastroenterology,"},{"key":"2025121313323367000_41.3.303.22","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010425"},{"key":"2025121313323367000_41.3.303.23","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0016-5085(92)91510-B","article-title":"Barrett\u2019s esophagus: age, prevalence, and extent of columnar epithelium.","volume":"103","author":"Cameron","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121313323367000_41.3.303.24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/00365529309096056","article-title":"The incidence of reflux oesophagitis. A study of endoscopy reports from a defined catchment area in Sweden.","volume":"28","author":"Loof","year":"1993","journal-title":"Scand J Gastroenterol"},{"key":"2025121313323367000_41.3.303.25","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530060048032"},{"key":"2025121313323367000_41.3.303.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80788-3"},{"key":"2025121313323367000_41.3.303.27","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(93)90034-9"},{"key":"2025121313323367000_41.3.303.28","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0022-5223(94)70381-7","article-title":"Surgical treatment of Barrett\u2019s carcinoma. Correlations between morphologic findings and prognosis.","volume":"107","author":"Lerut","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025121313323367000_41.3.303.29","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.5"},{"key":"2025121313323367000_41.3.303.30","first-page":"746","article-title":"Esophageal squamous carcinoma in five patients with Barrett\u2019s esophagus.","volume":"87","author":"Paraf","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"2025121313323367000_41.3.303.31","first-page":"167","article-title":"Carcinoma arising in Barrett\u2019s esophagus.","volume":"175","author":"Li","year":"1992","journal-title":"Surg Gynecol Obstet"},{"key":"2025121313323367000_41.3.303.32","unstructured":"Wilson JMG Junger G (1968) Principles and practice of screening for disease. (World Health Organisation, Geneva)."},{"key":"2025121313323367000_41.3.303.33","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420080085013"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.41.3.303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:32:44Z","timestamp":1765661564000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.41.3.303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9,1]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1997,9,1]]},"published-print":{"date-parts":[[1997,9,1]]}},"alternative-id":["10.1136\/gut.41.3.303"],"URL":"https:\/\/doi.org\/10.1136\/gut.41.3.303","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1997,9,1]]}}}