{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:51:44Z","timestamp":1761929504714,"version":"3.44.0"},"reference-count":46,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1997,10,1]]},"DOI":"10.1136\/gut.41.4.422","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"422-424","source":"Crossref","is-referenced-by-count":53,"title":["The aging oesophagus"],"prefix":"10.1136","volume":"41","author":[{"given":"JAN","family":"TACK","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GASTON","family":"VANTRAPPEN","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,10,1]]},"reference":[{"key":"2025090711372448000_41.4.422.1","first-page":"637","article-title":"The influence of age on esophageal acid defense mechanisms and spontaneous acid gastroesophageal reflux.","volume":"83","author":"Kruse-Andersen","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.2","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1172\/JCI105023","article-title":"Presbyesophagus, esophageal motility in nonagenerians.","volume":"45","author":"Soergel","year":"1964","journal-title":"J Clin Invest"},{"key":"2025090711372448000_41.4.422.3","first-page":"1569","article-title":"Aging-related alterations in human upper esophageal sphincter function.","volume":"85","author":"Fulp","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.4","first-page":"686","article-title":"The effects of age, sex, and smoking on normal pharyngoesophageal motility.","volume":"85","author":"Wilson","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.5","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90164-3"},{"key":"2025090711372448000_41.4.422.6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-3-371"},{"key":"2025090711372448000_41.4.422.7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/BF01072855","article-title":"Esophageal motility in the elderly.","volume":"22","author":"Ali Khan","year":"1977","journal-title":"Dig Dis"},{"key":"2025090711372448000_41.4.422.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02090352"},{"key":"2025090711372448000_41.4.422.9","first-page":"1480","article-title":"Clinical spectrum of esophageal aperistalsis in the elderly.","volume":"89","author":"Meshkinpour","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296157"},{"key":"2025090711372448000_41.4.422.11","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.167.3.8751689"},{"key":"2025090711372448000_41.4.422.12","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/22.1.37"},{"key":"2025090711372448000_41.4.422.13","first-page":"712","article-title":"Age does not affect basal gastric acid secretion in normal subjects and acid-peptic disease.","volume":"89","author":"Collen","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.14","first-page":"G772","article-title":"Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited.","volume":"268","author":"Ren","year":"1995","journal-title":"Am J Physiol"},{"key":"2025090711372448000_41.4.422.15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.8.799"},{"key":"2025090711372448000_41.4.422.16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296120"},{"key":"2025090711372448000_41.4.422.17","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536258"},{"key":"2025090711372448000_41.4.422.18","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300382"},{"key":"2025090711372448000_41.4.422.19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF01072928","article-title":"Esophageal ganglia and smooth muscle in the elderly.","volume":"23","author":"Eckardt","year":"1978","journal-title":"Dig Dis"},{"key":"2025090711372448000_41.4.422.20","doi-asserted-by":"publisher","DOI":"10.1007\/BF02493524"},{"key":"2025090711372448000_41.4.422.21","first-page":"20","article-title":"Dysphagia and its consequences in the elderly.","volume":"6","author":"Tibbing","year":"1991","journal-title":"Dysphagia"},{"key":"2025090711372448000_41.4.422.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1986.tb04202.x"},{"key":"2025090711372448000_41.4.422.23","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341256"},{"key":"2025090711372448000_41.4.422.24","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2214\/ajr.156.6.2028863","article-title":"Altered swallowing function in elderly patients without dysphagia: radiological findings in 56 cases.","volume":"158","author":"Ekberg","year":"1991","journal-title":"AJR Am J Roentgenol"},{"key":"2025090711372448000_41.4.422.25","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300105"},{"key":"2025090711372448000_41.4.422.26","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/23.4.280"},{"key":"2025090711372448000_41.4.422.27","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613045"},{"key":"2025090711372448000_41.4.422.28","doi-asserted-by":"publisher","DOI":"10.1007\/BF02071533"},{"key":"2025090711372448000_41.4.422.29","first-page":"965","article-title":"Prevalence of gastroesophageal reflux in elderly patients in a primary care setting.","volume":"86","author":"Mold","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1983.tb05124.x"},{"key":"2025090711372448000_41.4.422.31","first-page":"G1","article-title":"Evidence for diminished visceral pain with aging: studies using graded intraesophageal balloon distension.","volume":"272","author":"Lasch","year":"1997","journal-title":"Am J Physiol"},{"key":"2025090711372448000_41.4.422.32","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/20.5.365"},{"key":"2025090711372448000_41.4.422.33","first-page":"1053","article-title":"Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy.","volume":"90","author":"Collen","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"2025090711372448000_41.4.422.35","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90011-X"},{"key":"2025090711372448000_41.4.422.36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0016-5085(19)34918-2","article-title":"Basal and histalog-stimulated gastric secretion in control subjects and in patients with peptic ulcer or gastric ulcer.","volume":"45","author":"Grossman","year":"1963","journal-title":"Gastroenterology"},{"key":"2025090711372448000_41.4.422.37","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90123-6"},{"key":"2025090711372448000_41.4.422.38","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/23.2.121"},{"key":"2025090711372448000_41.4.422.39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510033131404"},{"key":"2025090711372448000_41.4.422.40","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0016-5085(92)91510-B","article-title":"Barrett\u2019s esophagus: Age, prevalence, and extent of columnar epithelium.","volume":"103","author":"Cameron","year":"1992","journal-title":"Gastroenterology"},{"key":"2025090711372448000_41.4.422.41","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/0016-5085(93)90420-H","article-title":"Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction.","volume":"104","author":"Pera","year":"1993","journal-title":"Gastroenterology"},{"key":"2025090711372448000_41.4.422.42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90349-2"},{"key":"2025090711372448000_41.4.422.43","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1994.01420300051007"},{"key":"2025090711372448000_41.4.422.44","first-page":"2201","article-title":"Esophageal adenocarcinoma associated with Barrett\u2019s esophagus: long-term management with laser ablation.","volume":"90","author":"Ertan","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2025090711372448000_41.4.422.45","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(95)70246-6"},{"key":"2025090711372448000_41.4.422.46","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1052-5157(18)30483-5","article-title":"Endoscopic diagnosis and treatment of esophageal cancer","volume":"4","author":"Goldschmid","year":"1994","journal-title":"Gastrointest Endosc Clin North Am"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.41.4.422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T18:37:33Z","timestamp":1757270253000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.41.4.422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10,1]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1997,10,1]]},"published-print":{"date-parts":[[1997,10,1]]}},"alternative-id":["10.1136\/gut.41.4.422"],"URL":"https:\/\/doi.org\/10.1136\/gut.41.4.422","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1997,10,1]]}}}