{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:53:48Z","timestamp":1779105228045,"version":"3.51.4"},"reference-count":47,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,6,24]]},"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Gastric acid secretion in Japanese subjects decreases with aging. One of the possible causative mechanisms of this attenuated acid secretion is speculated to be a\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    induced chronic gastritis. The infection rate of this microorganism has decreased recently in Japan.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To investigate whether gastric acid secretion has altered over the past 20 years, and if so, what the influence of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection might be in the Japanese population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Subjects and methods<\/jats:italic>\n                    \u2014Gastric acid secretion, serum gastrin and pepsinogen I and II concentrations, and\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection were determined in 110 Japanese subjects in both the 1970s and 1990s.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Basal acid output as well as maximal acid output have greatly increased over the past 20 years, not only in individuals with\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection but also in those without infection. Furthermore, subjects with\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection tended to show decreased gastric acid secretion in comparison with those without infection, particularly in geriatric subjects. There was a positive correlation between gastric acid secretion and serum pepsinogen I concentrations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014In Japan, both basal and stimulated gastric acid secretion have increased over the past 20 years; some unknown factors other than the decrease in\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection may play an important role in this phenomenon.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.4.452","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"452-458","source":"Crossref","is-referenced-by-count":148,"title":["<i>Helicobacter pylori<\/i>\n                    independent chronological change in gastric acid secretion in the Japanese"],"prefix":"10.1136","volume":"41","author":[{"given":"Y","family":"Kinoshita","sequence":"first","affiliation":[{"name":"aDivision of Gerontology, Department of Medicine, Kobe University School of Medicine, 7\u20135\u20131, Kusunoki-cho, Chuo-ku, Kobe 650, Japan, \n\nbDivision of Gastroenterology and Hepatology, Department of Medicine, \n\ncDepartment of Metabolism and Clinical Nutrition, Kyoto University, Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Kawanami","sequence":"additional","affiliation":[{"name":"aDivision of Gerontology, Department of Medicine, Kobe University School of Medicine, 7\u20135\u20131, Kusunoki-cho, Chuo-ku, Kobe 650, Japan, \n\nbDivision of Gastroenterology and Hepatology, Department of Medicine, \n\ncDepartment of Metabolism and Clinical Nutrition, Kyoto University, Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kishi","sequence":"additional","affiliation":[{"name":"aDivision of Gerontology, Department of Medicine, Kobe University School of Medicine, 7\u20135\u20131, Kusunoki-cho, Chuo-ku, Kobe 650, Japan, \n\nbDivision of Gastroenterology and Hepatology, Department of Medicine, \n\ncDepartment of Metabolism and Clinical Nutrition, Kyoto University, Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nakata","sequence":"additional","affiliation":[{"name":"aDivision of Gerontology, Department of Medicine, Kobe University School of Medicine, 7\u20135\u20131, Kusunoki-cho, Chuo-ku, Kobe 650, Japan, \n\nbDivision of Gastroenterology and Hepatology, Department of Medicine, \n\ncDepartment of Metabolism and Clinical Nutrition, Kyoto University, Graduate School of Medicine, Kyoto, 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