{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:39:04Z","timestamp":1770482344877,"version":"3.49.0"},"reference-count":26,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,6,23]]},"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014The incidence of adenocarcinoma of the oesophagus and gastric cardia is increasing rapidly. Barrett\u2019s oesophagus is the major risk factor. Intestinal metaplasia at the squamocolumnar junction in the absence of Barrett\u2019s oesophagus is common but its relation to adenocarcinoma and gastro-oesophageal reflux disease is unclear.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To study the prevalence and clinical, endoscopic, and histological associations of intestinal metaplasia at the squamocolumnar junction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Biopsy specimens were taken from 120 randomly selected patients undergoing routine diagnostic endoscopy. Eight biopsy specimens, taken from above and below the squamocolumnar junction, gastric fundus, and gastric antrum, were stained with haematoxylin\/eosin, alcian blue\/periodic acid-Schiff, and Gimenez, and graded independently by one pathologist.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Intestinal metaplasia at the squamocolumnar junction was found in 21 patients (18%). Metaplasia was associated with increasing age (p&lt;0.01) and antral intestinal metaplasia (p=0.04). Logistic regression analysis revealed that age was the only independent predictor (p&lt;0.01). There was no association with symptomatic, endoscopic, or histological markers of gastro-oesophageal reflux disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Intestinal metaplasia at the squamocolumnar junction is a common finding. It is associated with increasing age but not gastro-oesophageal reflux disease.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.5.585","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"585-589","source":"Crossref","is-referenced-by-count":107,"title":["Intestinal metaplasia at the squamocolumnar junction in patients attending for diagnostic gastroscopy"],"prefix":"10.1136","volume":"41","author":[{"given":"N J","family":"Trudgill","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology and Histopathology, Northern General Hospital, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Suvarna","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Histopathology, Northern General Hospital, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K C","family":"Kapur","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Histopathology, Northern General Hospital, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Riley","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Histopathology, Northern General Hospital, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"2025112110072056000_41.5.585.1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.314"},{"key":"2025112110072056000_41.5.585.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"2025112110072056000_41.5.585.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajcp\/70.1.1","article-title":"Adenocarcinoma complicating columnar epithelium-lined (Barrett\u2019s) esophagus.","volume":"70","author":"Haggitt","year":"1978","journal-title":"Am J Clin Pathol"},{"key":"2025112110072056000_41.5.585.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80010-8"},{"key":"2025112110072056000_41.5.585.5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.4.574"},{"key":"2025112110072056000_41.5.585.6","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.agast960614"},{"key":"2025112110072056000_41.5.585.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90349-2"},{"key":"2025112110072056000_41.5.585.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308357"},{"key":"2025112110072056000_41.5.585.9","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90123-6"},{"key":"2025112110072056000_41.5.585.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197608262950904"},{"key":"2025112110072056000_41.5.585.11","first-page":"728","article-title":"Barrett esophagus: the columnar-epithelial-lined lower esophagus.","volume":"46","author":"Burgess","year":"1971","journal-title":"Mayo Clin Proc"},{"key":"2025112110072056000_41.5.585.12","unstructured":"Morson BC Dawson IMP Day DW Jass JR Price AB Williams GT (1990) Morson and Dawson\u2019s gastrointestinal pathology. 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