{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:40:17Z","timestamp":1768462817302,"version":"3.49.0"},"reference-count":38,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,5,12]]},"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014It has recently been shown that humoral antigastric autoreactivities occur in a substantial number of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infected patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims\u2014<\/jats:italic>\n                    To analyse the relevance of such antigastric autoantibodies for histological and serological parameters of the infection as well as for the clinical course.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Gastric biopsy samples and sera from 126 patients with upper abdominal complaints were investigated for evidence of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection using histology and serology. Autoantibodies against epitopes in human gastric mucosa were detected by immunohistochemical techniques. Histological and clinical findings of all patients were then correlated with the detection of antigastric autoantibodies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection was significantly associated with antigastric autoantibodies reactive with the luminal membrane of the foveolar epithelium and with canalicular structures within parietal cells. The presence of the latter autoantibodies was significantly correlated with the severity of body gastritis, gastric mucosa atrophy, elevated fasting gastrin concentrations, and a decreased ratio of serum pepsinogen I:II. Furthermore the presence of anticanalicular autoantibodies was associated with a greater than twofold reduced prevalence for duodenal ulcer.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014The data indicate that antigastric autoantibodies play a role in the pathogenesis and outcome of\n                    <jats:italic>H pylori<\/jats:italic>\n                    gastritis, in particular in the development of gastric mucosal atrophy.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.5.619","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"619-623","source":"Crossref","is-referenced-by-count":108,"title":["Antigastric autoantibodies in\n                    <i>Helicobacter pylori<\/i>\n                    infection: implications of histological and clinical parameters of gastritis"],"prefix":"10.1136","volume":"41","author":[{"given":"G","family":"Faller","sequence":"first","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Steininger","sequence":"additional","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kr\u00e4nzlein","sequence":"additional","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Maul","sequence":"additional","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kerkau","sequence":"additional","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hensen","sequence":"additional","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E G","family":"Hahn","sequence":"additional","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kirchner","sequence":"additional","affiliation":[{"name":"aInstitute of Pathology, University of Erlangen-N\u00fcrnberg, Krankenhausstrasse 8\u201310, D-91054 Erlangen, Germany, \n\nbDepartment of Internal Medicine I, University of Erlangen-N\u00fcrnberg, \n\ncInstitute of Virology, University of W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"2025121303481672000_41.5.619.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92719-8"},{"key":"2025121303481672000_41.5.619.2","first-page":"1596","article-title":"New small animal model for human gastric Helicobacter pylori infection: success in both nude and euthymic mice.","volume":"86","author":"Karita","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"2025121303481672000_41.5.619.3","first-page":"721","article-title":"Helicobacter pylori. 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