{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:56:38Z","timestamp":1791280598028,"version":"4.1.0"},"reference-count":21,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,5,29]]},"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Uncontrolled studies of lactose intolerant subjects have shown that symptom severity decreases after chronic lactose consumption. Adaptation of the colonic flora might explain this improvement.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To compare the effects of regular administration of either lactose or sucrose on clinical tolerance and bacterial adaptation to lactose.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Forty six lactose intolerant subjects underwent two 50\u2009g lactose challenges on days 1 and 15. Between these days they were given 34\u2009g of lactose or sucrose per day, in a double blind protocol. Stool samples were obtained on days 0 and 14, to measure faecal \u03b2-galactosidase and pH. Symptoms, breath H\n                    <jats:sub>2<\/jats:sub>\n                    excretion, faecal weight and electrolytes, and orofaecal transit time were assessed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Except for faecal weight, symptoms were significantly milder during the second challenge in both groups, and covariance analysis showed no statistical difference between them. In the lactose group, but not in the sucrose group, faecal \u03b2-galactosidase activity increased, pH dropped, and breath H\n                    <jats:sub>2<\/jats:sub>\n                    excretion decreased.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014Bacterial adaptation occurred when lactose intolerant subjects ingested lactose for 13 days, and all symptoms except diarrhoea regressed. Clinical improvement was also observed in the control group which displayed no signs of metabolic adaptation. This suggests that improved clinical tolerance may be just a placebo effect.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.5.632","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"632-635","source":"Crossref","is-referenced-by-count":90,"title":["Improved clinical tolerance to chronic lactose ingestion in subjects with lactose intolerance: a placebo effect?"],"prefix":"10.1136","volume":"41","author":[{"given":"F","family":"Briet","sequence":"first","affiliation":[{"name":"aINSERM U290, H\u00f4pital Saint-Lazare, 107 bis rue du Faubourg Saint-Denis, 75010 Paris, France, \n\nbChaire de Biologie en Vue des Applications, Coservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pochart","sequence":"additional","affiliation":[{"name":"aINSERM U290, H\u00f4pital Saint-Lazare, 107 bis rue du Faubourg Saint-Denis, 75010 Paris, France, \n\nbChaire de Biologie en Vue des Applications, Coservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Marteau","sequence":"additional","affiliation":[{"name":"aINSERM U290, H\u00f4pital Saint-Lazare, 107 bis rue du Faubourg Saint-Denis, 75010 Paris, France, \n\nbChaire de Biologie en Vue des Applications, Coservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Flourie","sequence":"additional","affiliation":[{"name":"aINSERM U290, H\u00f4pital Saint-Lazare, 107 bis rue du Faubourg Saint-Denis, 75010 Paris, France, \n\nbChaire de Biologie en Vue des Applications, Coservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Arrigoni","sequence":"additional","affiliation":[{"name":"aINSERM U290, H\u00f4pital Saint-Lazare, 107 bis rue du Faubourg Saint-Denis, 75010 Paris, France, \n\nbChaire de Biologie en Vue des Applications, Coservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Rambaud","sequence":"additional","affiliation":[{"name":"aINSERM U290, H\u00f4pital Saint-Lazare, 107 bis rue du Faubourg Saint-Denis, 75010 Paris, France, \n\nbChaire de Biologie en Vue des Applications, Coservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, 75141 Paris Cedex 03, 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