{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:23:23Z","timestamp":1790159003972,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,6,4]]},"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:p>\n                  <jats:italic>Background<\/jats:italic>\u2014In addition to its absorptive function the capacity of the colon to retain fluid might be relevant in compensating for increased fluid loads and prevention of diarrhoea. The distal colon is considered to be mainly a conduit without extensive storage function.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Aims<\/jats:italic>\u2014To evaluate colonic volume capacity in a model of pure osmotic diarrhoea.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Methods<\/jats:italic>\u2014A non-absorbable, iso-osmotic solution (OS) containing polyethylene glycol (500\u2009ml) was infused into the caecum of nine healthy volunteers; the control group (n=5) received an equal amount of an easily absorbable electrolyte solution (ES). Fluids were radiolabelled with technetium-99m and gamma camera images were obtained for 48 hours. Counts in the proximal and distal colon were measured and regional and overall colonic transit and stool output were quantified.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Results<\/jats:italic>\u2014After OS, in contrast to ES, faecal output was increased significantly (p&lt;0.05), but colonic transit after OS was not different from transit after ES (p&gt;0.05). This indicates storage of OS in the colon: after OS infusion, counts in the proximal colon decreased linearly while the distal colon stored approximately 30% of radioactivity for the whole 48 hour study period. After OS, stool output correlated with distal (p&lt;0.01), but not with proximal (p&gt;0.05), colonic transit. In constrast, after ES, stool output was determined by proximal colonic transit (p&lt;0.05) but not by transit through the distal colon (p&gt;0.05).<\/jats:p>\n               <jats:p>\n                  <jats:italic>Conclusion<\/jats:italic>\u2014The distal colon retains non-absorbable fluid volumes extensively. In our model transit through the distal colon\u2014but not the proximal colon\u2014determined the time at which diarrhoea occurred.<\/jats:p>","DOI":"10.1136\/gut.41.5.658","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"658-663","source":"Crossref","is-referenced-by-count":16,"title":["The distal colon provides reserve storage capacity during colonic fluid overload"],"prefix":"10.1136","volume":"41","author":[{"given":"J","family":"Hammer","sequence":"first","affiliation":[{"name":"aAKH Wien, Universit\u00e4tsklinik f\u00fcr Innere Medizin IV, Abteilung f\u00fcr Gastroenterologie und Hepatologie, W\u00e4hringer G\u00fcrtel 18\u201320, A-1090 Vienna, Austria, \n\nbUniversit\u00e4tsklinik f\u00fcr Nuklearmedizin, \n\ncInstitut f\u00fcr Biomedizinische Technik und Physik, Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pruckmayer","sequence":"additional","affiliation":[{"name":"aAKH Wien, Universit\u00e4tsklinik f\u00fcr Innere Medizin IV, Abteilung f\u00fcr Gastroenterologie und Hepatologie, W\u00e4hringer G\u00fcrtel 18\u201320, A-1090 Vienna, Austria, \n\nbUniversit\u00e4tsklinik f\u00fcr Nuklearmedizin, \n\ncInstitut f\u00fcr Biomedizinische Technik und Physik, Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Bergmann","sequence":"additional","affiliation":[{"name":"aAKH Wien, Universit\u00e4tsklinik f\u00fcr Innere Medizin IV, Abteilung f\u00fcr Gastroenterologie und Hepatologie, W\u00e4hringer G\u00fcrtel 18\u201320, A-1090 Vienna, Austria, \n\nbUniversit\u00e4tsklinik f\u00fcr Nuklearmedizin, \n\ncInstitut f\u00fcr Biomedizinische Technik und Physik, Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kletter","sequence":"additional","affiliation":[{"name":"aAKH Wien, Universit\u00e4tsklinik f\u00fcr Innere Medizin IV, Abteilung f\u00fcr Gastroenterologie und Hepatologie, W\u00e4hringer G\u00fcrtel 18\u201320, A-1090 Vienna, Austria, \n\nbUniversit\u00e4tsklinik f\u00fcr Nuklearmedizin, \n\ncInstitut f\u00fcr Biomedizinische Technik und Physik, Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gangl","sequence":"additional","affiliation":[{"name":"aAKH Wien, Universit\u00e4tsklinik f\u00fcr Innere Medizin IV, Abteilung f\u00fcr Gastroenterologie und Hepatologie, W\u00e4hringer G\u00fcrtel 18\u201320, A-1090 Vienna, Austria, \n\nbUniversit\u00e4tsklinik f\u00fcr Nuklearmedizin, \n\ncInstitut f\u00fcr Biomedizinische Technik und Physik, Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"2025090800263904000_41.5.658.1","first-page":"733","article-title":"The contribution of the colon to electrolyte and water conservation in man.","volume":"81","author":"Phillips","year":"1973","journal-title":"J Lab Clin Med"},{"key":"2025090800263904000_41.5.658.2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/0016-5085(78)90246-9","article-title":"Capacity of the human colon to absorb fluid.","volume":"74","author":"Debongnie","year":"1978","journal-title":"Gastroenterology"},{"key":"2025090800263904000_41.5.658.3","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0016-5085(19)30508-6","article-title":"Absorption of short chain fatty acids by the colon.","volume":"78","author":"Ruppin","year":"1980","journal-title":"Gastroenterology"},{"key":"2025090800263904000_41.5.658.4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114927"},{"key":"2025090800263904000_41.5.658.5","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0016-5085(86)80004-X","article-title":"Colonic transit scintigraphy. 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