{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:54:15Z","timestamp":1782996855395,"version":"3.54.5"},"reference-count":17,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,5,12]]},"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Peripheral kappa receptor agonists may provide a new therapeutic approach for the treatment of functional dyspepsia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To evaluate, in a large multicentre trial, the use of the kappa receptor agonist fedotozine to improve symptoms associated with functional dyspepsia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Two or more of the following persistent symptoms were required for inclusion: epigastric pain, early satiety, epigastric fullness or distension, nausea, vomiting, and a feeling of slow digestion. On completing a two week placebo washout, 271 patients were randomised into two groups to receive 30\u2009mg fedotozine three times daily or placebo for six weeks under double blind conditions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014The improvement in the overall intensity of dyspeptic symptoms (main efficacy criterion) was significantly more pronounced in the fedotozine group (p=0.002) compared with placebo, as was epigastric pain (p=0.004) and nausea (p=0.01); the improvement in postprandial fullness was nearly significant (p=0.052). Inability to finish a meal and slow digestion were unaffected. The patient global score, the average of the five individual symptoms, was notably ameliorated with fedotozine (p=0.021). The safety of fedotozine was excellent.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Fedotozine at 30\u2009mg three times daily is safe and more effective than placebo for the relief of key symptoms associated with functional dyspepsia.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.5.664","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"664-668","source":"Crossref","is-referenced-by-count":84,"title":["Efficacy and safety of the peripheral kappa agonist fedotozine versus placebo in the treatment of functional dyspepsia"],"prefix":"10.1136","volume":"41","author":[{"given":"N W","family":"Read","sequence":"first","affiliation":[{"name":"aCentre for Human Nutrition, University of Sheffield, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK, \n\nbInstitut de Recherche Jouveinal, Fresnes, France, \n\ncRotherham District General Hospital, Rotherham, UK, \n\ndDepartment of Medicine, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Abitbol","sequence":"additional","affiliation":[{"name":"aCentre for Human Nutrition, University of Sheffield, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK, \n\nbInstitut de Recherche Jouveinal, Fresnes, France, \n\ncRotherham District General Hospital, Rotherham, UK, \n\ndDepartment of Medicine, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K D","family":"Bardhan","sequence":"additional","affiliation":[{"name":"aCentre for Human Nutrition, University of Sheffield, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK, \n\nbInstitut de Recherche Jouveinal, Fresnes, France, \n\ncRotherham District General Hospital, Rotherham, UK, \n\ndDepartment of Medicine, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Whorwell","sequence":"additional","affiliation":[{"name":"aCentre for Human Nutrition, University of Sheffield, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK, \n\nbInstitut de Recherche Jouveinal, Fresnes, France, \n\ncRotherham District General Hospital, Rotherham, UK, \n\ndDepartment of Medicine, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Fraitag","sequence":"additional","affiliation":[{"name":"aCentre for Human Nutrition, University of Sheffield, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK, \n\nbInstitut de Recherche Jouveinal, Fresnes, France, \n\ncRotherham District General Hospital, Rotherham, UK, \n\ndDepartment of Medicine, University Hospital of South Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"2025121220411025000_41.5.664.1","first-page":"47","article-title":"Prevalence of symptoms of dyspepsia in the community.","volume":"i","author":"Jones","year":"1989","journal-title":"Lancet"},{"key":"2025121220411025000_41.5.664.2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/0016-5085(92)90764-P","article-title":"Dyspepsia and dyspepsia subgroups. A population-based study.","volume":"102","author":"Talley","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121220411025000_41.5.664.3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90726-2"},{"key":"2025121220411025000_41.5.664.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307517"},{"key":"2025121220411025000_41.5.664.5","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0016-5085(85)80083-4","article-title":"Manometric evaluation of functional upper gut symptoms.","volume":"88","author":"Malagelada","year":"1985","journal-title":"Gastroenterology"},{"key":"2025121220411025000_41.5.664.6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0016-5085(86)90069-7","article-title":"Interdigestive gastroduodenal motility and serum motilin levels in patients with idiopathic delay in gastric emptying.","volume":"90","author":"Labo","year":"1986","journal-title":"Gastroenterology"},{"key":"2025121220411025000_41.5.664.7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0016-5085(86)90444-0","article-title":"Relationship between impaired gastric emptying and abnormal gastrointestinal motility.","volume":"91","author":"Camilleri","year":"1986","journal-title":"Gastroenterology"},{"key":"2025121220411025000_41.5.664.8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-4-449"},{"key":"2025121220411025000_41.5.664.9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.1.5"},{"key":"2025121220411025000_41.5.664.10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3109\/00365528509088842","article-title":"The association between non-ulcer dyspepsia and other gastrointestinal disorders.","volume":"20","author":"Talley","year":"1985","journal-title":"Scand J Gastroenterol"},{"key":"2025121220411025000_41.5.664.11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.2042-7158.1990.tb07056.x","article-title":"Effects of fedotozine on gastrointestinal motility in dogs: mechanism of action and related pharmacokinetics.","volume":"42","author":"Pascaud","year":"1990","journal-title":"J Pharm Pharmacol"},{"key":"2025121220411025000_41.5.664.12","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90265-8"},{"key":"2025121220411025000_41.5.664.13","first-page":"A538","article-title":"Kappa receptors play a major role in the enhanced antinociceptive effect of fedotozine on colonic hypersensitivity in rat [abstract].","volume":"104","author":"Langlois","year":"1993","journal-title":"Gastroenterology"},{"key":"2025121220411025000_41.5.664.14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2982.1990.tb00033.x","article-title":"Antagonism of stress-induced motor alteration and plasma cortisol release by fedotozine (JO 1196) in dogs.","volume":"2","author":"Gue","year":"1990","journal-title":"J Gastrointest Motil"},{"key":"2025121220411025000_41.5.664.15","first-page":"A437","article-title":"Fedotozine increases threshold of discomfort to gastric distension in healthy subjects [abstract].","volume":"102","author":"Coffin","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121220411025000_41.5.664.16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087560"},{"key":"2025121220411025000_41.5.664.17","doi-asserted-by":"publisher","DOI":"10.1007\/BF02209014"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.41.5.664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:41:20Z","timestamp":1765600880000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.41.5.664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11,1]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1997,11,1]]},"published-print":{"date-parts":[[1997,11,1]]}},"alternative-id":["10.1136\/gut.41.5.664"],"URL":"https:\/\/doi.org\/10.1136\/gut.41.5.664","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11,1]]}}}