{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:47:44Z","timestamp":1778680064086,"version":"3.51.4"},"reference-count":17,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,8,7]]},"published-print":{"date-parts":[[1997,12,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background\u2014<\/jats:italic>\n                    Eradication of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    cures and prevents the relapse of duodenal ulceration and also results in histological resolution of chronic active gastritis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u2014To compare four treatment regimens lasting seven days of a proton pump inhibitor and two antibiotics in the eradication of\n                    <jats:italic>H pylori<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients<\/jats:italic>\n                    \u2014Men or women with\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive duodenal ulceration or gastritis, or both.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014A single blind, prospectively randomised, parallel group, comparative, multicentre study. After a positive CLO test, patients underwent histology,\n                    <jats:italic>H pylori<\/jats:italic>\n                    culture, and a\n                    <jats:sup>13<\/jats:sup>\n                    C urea breath test to confirm\n                    <jats:italic>H pylori<\/jats:italic>\n                    status. Treatment with one of four regimens: LAC, LAM, LCM, or OAM, where L is 30 mg of lansoprazole twice daily, A is 1 g of amoxycillin twice daily, M is 400 mg of metronidazole twice daily, C is 250 mg of clarithromycin twice daily, and O is 20 mg of omeprazole twice daily, was assigned randomly. A follow up breath test was done at least 28 days after completing treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication (intention to treat) was 104\/121 (86.0%) with LAC, 87\/131 (66.4%) with LAM, 103\/118 (87.3%) with LCM, and 94\/126 (74.6%) with OAM. There was a significant difference (p &lt; 0.001) in the proportion of patients in whom eradication was successful between LAC and LCM when compared with LAM, but no significant difference (p = 0.15) between LAM and OAM. Metronidazole resistance before treatment was identified as a significant prognostic factor with regard to eradication of\n                    <jats:italic>H pylori<\/jats:italic>\n                    . The regimens which contained metronidazole were significantly less effective than those without metronidazole in the presence of pretreatment resistant\n                    <jats:italic>H pylori<\/jats:italic>\n                    . There was no difference among the treatment groups with regard to the incidence and severity of adverse events reported.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014All four treatment regimens were safe and effective in eradicating\n                    <jats:italic>H pylori<\/jats:italic>\n                    in the patient population studied. LAC was the most efficacious treatment in patients with pretreatment metronidazole resistant\n                    <jats:italic>H pylori<\/jats:italic>\n                    , and was significantly better than LAM and OAM in this group of patients.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.6.735","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"735-739","source":"Crossref","is-referenced-by-count":128,"title":["One week triple therapy for\n                    <i>Helicobacter pylori<\/i>\n                    : a multicentre comparative study"],"prefix":"10.1136","volume":"41","author":[{"given":"J J","family":"Misiewicz","sequence":"first","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Harris","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K D","family":"Bardhan","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Levi","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"O\u2019Morain","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B T","family":"Cooper","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G D","family":"Kerr","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Dixon","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Langworthy","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Piper","sequence":"additional","affiliation":[{"name":"aCentral Middlesex Hospital, London, \n\nbRotherham District Hospital, \n\ncNorthwick Park Hospital, Slough, \n\ndThe Meath Hospital, Dublin, \n\neRoyal Hospital, Birmingham, \n\nfRoyal Shrewsbury Hospital, \n\ngGeneral Infirmary, Leeds, \n\nhLederle Laboratories, Gosport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Lansoprazole Helicobacter Study 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Is Helicobacter pylori a cause of non-ulcer dyspepsia? In: Malfertheiner P, Ditschumeit H eds. Helicobacter pylori, gastritis and peptic ulcer. Springer Verlag, Berlin 1990. .","DOI":"10.1007\/978-3-642-75315-2_53"},{"key":"2025120519270969000_41.6.735.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91545-5"},{"key":"2025120519270969000_41.6.735.4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0016-5085(88)90606-3","article-title":"Campylobacter pyloridis\u2014associated chronic antral gastritis.","volume":"94","author":"Rauws","year":"1988","journal-title":"Gastroenterology"},{"key":"2025120519270969000_41.6.735.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520010077036"},{"key":"2025120519270969000_41.6.735.6","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199409000-00004"},{"key":"2025120519270969000_41.6.735.7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.Suppl_1.A4"},{"key":"2025120519270969000_41.6.735.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1996.727119000.x"},{"key":"2025120519270969000_41.6.735.9","first-page":"905","article-title":"The European 13C-urea breath test for the detection of H. pylori.","volume":"3","author":"Logan","year":"1991","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025120519270969000_41.6.735.10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.11.1562"},{"key":"2025120519270969000_41.6.735.11","unstructured":"Karim QN, Logan RPH. The epidemiology of Helicobacter pylori (H. pylori) antimicrobial resistance\u2014preliminary findings of a national survey [abstract]. Gut1995;37(suppl 2):A6. ."},{"key":"2025120519270969000_41.6.735.12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2036.1995.tb00349.x","article-title":"Rapid eradication of Helicobacter pylori infection.","volume":"9","author":"Bell","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"2025120519270969000_41.6.735.13","unstructured":"Bateson M, Diffey BL. Radical therapy for duodenal ulcer [abstract]. 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