{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T21:47:26Z","timestamp":1766440046722,"version":"3.48.0"},"reference-count":41,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,6,24]]},"published-print":{"date-parts":[[1997,12,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    gastritis may spread proximally in the stomach during profound acid inhibition.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To examine histological gastric body changes and epithelial cell proliferation before and after treatment with lansoprazole.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and methods<\/jats:italic>\n                    \u2014Patients diagnosed as having reflux oesophagitis grade 1 or 2 were enrolled and treated for 12 weeks with lansoprazole (30 mg every morning). After 12 weeks, 103 of the 118 patients appeared endoscopically healed and were asymptomatic; they then received maintenance treatment with 15 or 30 mg lansoprazole daily. Biopsy specimens obtained from similar sites before and after treatment, were available from 90 patients after a median of 64 weeks (range 15\u201373 weeks). Epithelial cell proliferation was determined by the number of Ki-67 antigen positive cells per gland.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Of these 90 patients, 44 (49%) were found to be infected with\n                    <jats:italic>H pylori<\/jats:italic>\n                    . Their median inflammation score had increased from grade 1 before to grade 2 after treatment (p&lt;0.0001). Initially, the number of Ki-67 antigen positive cells per gland was significantly higher in the\n                    <jats:italic>H pylori<\/jats:italic>\n                    infected than in the uninfected group and increased further after treatment (p&lt;0.0001). In uninfected patients, no significant change in inflammation or proliferation occurred during treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014A marked increase in body gastritis was observed in\n                    <jats:italic>H pylori<\/jats:italic>\n                    infected individuals during long term treatment with the proton pump inhibitor lansoprazole. Epithelial cell proliferation and atrophy also increased in infected but not in uninfected patients.\n                  <\/jats:p>","DOI":"10.1136\/gut.41.6.740","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"740-747","source":"Crossref","is-referenced-by-count":59,"title":["<i>Helicobacter pylori<\/i>\n                    gastritis and epithelial cell proliferation in patients with reflux oesophagitis after treatment with lansoprazole"],"prefix":"10.1136","volume":"41","author":[{"given":"A E","family":"Berstad","sequence":"first","affiliation":[{"name":"aLaboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo,The National Hospital, Rikshospitalet, N-0027 Oslo, Norway, \n\nbDivision of Gastroenterology, Medical Department, \n\ncDepartment of Pathology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Hatlebakk","sequence":"additional","affiliation":[{"name":"aLaboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo,The National Hospital, Rikshospitalet, N-0027 Oslo, Norway, \n\nbDivision of Gastroenterology, Medical Department, \n\ncDepartment of Pathology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Maartmann-Moe","sequence":"additional","affiliation":[{"name":"aLaboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo,The National Hospital, Rikshospitalet, N-0027 Oslo, Norway, \n\nbDivision of Gastroenterology, Medical Department, \n\ncDepartment of Pathology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Berstad","sequence":"additional","affiliation":[{"name":"aLaboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo,The National Hospital, Rikshospitalet, N-0027 Oslo, Norway, \n\nbDivision of Gastroenterology, Medical Department, \n\ncDepartment of Pathology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Brandtzaeg","sequence":"additional","affiliation":[{"name":"aLaboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo,The National Hospital, Rikshospitalet, N-0027 Oslo, Norway, \n\nbDivision of Gastroenterology, Medical Department, \n\ncDepartment of Pathology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,12,1]]},"reference":[{"key":"2025121222131395000_41.6.740.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.1.12"},{"key":"2025121222131395000_41.6.740.2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9041231"},{"key":"2025121222131395000_41.6.740.3","first-page":"2120","article-title":"Helicobacter pylori does not migrate from the antrum to the corpus in response to omeprazole.","volume":"91","author":"Graham","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121222131395000_41.6.740.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-3-199408010-00001"},{"key":"2025121222131395000_41.6.740.5","first-page":"461","article-title":"Local acid production and Helicobacter pylori: a unifying hypothesis of gastroduodenal disease.","volume":"7","author":"Lee","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121222131395000_41.6.740.6","first-page":"1401","article-title":"Increase of Helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety.","volume":"90","author":"Kuipers","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2025121222131395000_41.6.740.7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3109\/00365529409094876","article-title":"Effects of omeprazole and eradication of Helicobacter pylori on gastric and duodenal mucosal enzyme activities and DNA in duodenal ulcer patients.","volume":"29","author":"Vetvik","year":"1994","journal-title":"Scand J Gastroenterol"},{"key":"2025121222131395000_41.6.740.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341603"},{"key":"2025121222131395000_41.6.740.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91084-0"},{"key":"2025121222131395000_41.6.740.10","unstructured":"Sakaki N, Momma K, Egawa N, Yamada Y, Kan T, Ishiwata J. 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