{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:36:25Z","timestamp":1780104985669,"version":"3.54.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,7,16]]},"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Coexistent primary biliary cirrhosis (PBC) and coeliac disease has been recorded but the association has not been systematically studied.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To determine relative prevalences of PBC and coeliac disease in a defined population over a 12 year period.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and methods<\/jats:italic>\n                    \u2014All patients with PBC or coeliac disease in a stable population of 250\u2009000 in South Wales were identified from a clinical register and laboratory records.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Sixty seven patients with PBC and 143 patients with coeliac disease have been diagnosed and followed over a median of 86 (4\u2013135) months; point prevalences in 1996 were 20 per 100\u2009000 for PBC and 54 per 100\u2009000 for coeliac disease. PBC in patients with coeliac disease was sought by investigating abnormal liver function tests. Ten (7%) had persistent abnormalities and three had PBC. Coeliac disease in patients with PBC was sought by investigating malabsorption, haematinic deficiency, positive antigliadin antibody, or coeliac disease family history. Eleven patients underwent duodenal biopsy revealing one further coeliac disease case. Four patients (three women) have both conditions giving a point prevalence for patients with both conditions of 1.6 per 100\u2009000 (95% confidence limits 0.44 to 4.1 per 100\u2009000). Prevalence of PBC in patients with coeliac disease was 3% and of coeliac disease in patients with PBC was 6%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014A 12 year study of a stable 250\u2009000 population revealed a relative prevalence of PBC in 3% of 143 patients with coeliac disease and of coeliac disease in 6% of 67 patients with PBC. PBC and coeliac disease are therefore associated. Screening for PBC in patients with coeliac disease using antimitochondrial antibody testing and screening for coeliac disease in patients with PBC with antigliadin antibody testing or duodenal biopsy are recommended.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.1.120","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"120-122","source":"Crossref","is-referenced-by-count":156,"title":["The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences"],"prefix":"10.1136","volume":"42","author":[{"given":"J G C","family":"Kingham","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Singleton Hospital, Swansea SA2 8QA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Singleton Hospital, Swansea SA2 8QA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"2025121311542500000_42.1.120.1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(78)90480-4","article-title":"Primary biliary cirrhosis and coeliac disease, an association.","volume":"i","author":"Logan","year":"1978","journal-title":"Lancet"},{"key":"2025121311542500000_42.1.120.2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/BF01317215","article-title":"An association between primary biliary cirrhosis and jejunal villous atrophy resembling celiac disease.","volume":"24","author":"Iliffe","year":"1979","journal-title":"Dig Sci"},{"key":"2025121311542500000_42.1.120.3","first-page":"796","article-title":"Adult celiac disease and primary biliary cirrhosis.","volume":"81","author":"Behr","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"2025121311542500000_42.1.120.4","doi-asserted-by":"publisher","DOI":"10.3109\/00365528209181069"},{"key":"2025121311542500000_42.1.120.5","first-page":"547","article-title":"Primary biliary cirrhosis and adult celiac disease.","volume":"156","author":"Ginn","year":"1992","journal-title":"West J Med"},{"key":"2025121311542500000_42.1.120.6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00042737-199403000-00013","article-title":"Primary biliary cirrhosis associated with coeliac disease.","volume":"6","author":"Lohr","year":"1994","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121311542500000_42.1.120.7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/hep.1840110317","article-title":"Epidemiology of primary biliary cirrhosis in a defined rural population in the northern part of Sweden.","volume":"11","author":"Danielsson","year":"1990","journal-title":"Hepatology"},{"key":"2025121311542500000_42.1.120.8","unstructured":"Gardner MJ Altman DG (1989) Statistics with confidence\u2014the confidence interval and statistical guidelines. (BMJ Publishing Group, London)."},{"key":"2025121311542500000_42.1.120.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.281.6250.1258"},{"key":"2025121311542500000_42.1.120.10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0016-5085(86)90929-7","article-title":"Prevalence and \u201cincidence\u201d of celiac disease in Edinburgh and the Lothian region of Scotland.","volume":"90","author":"Logan","year":"1986","journal-title":"Gastroenterology"},{"key":"2025121311542500000_42.1.120.11","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.10.940"},{"key":"2025121311542500000_42.1.120.12","first-page":"377","article-title":"The epidemiology of primary biliary cirrhosis in North-East England: an increasingly common disease.","volume":"276","author":"Myszor","year":"1990","journal-title":"Q J Med"},{"key":"2025121311542500000_42.1.120.13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.Suppl_1.A5"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.42.1.120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:54:34Z","timestamp":1765655674000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.42.1.120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1998,1,1]]},"published-print":{"date-parts":[[1998,1,1]]}},"alternative-id":["10.1136\/gut.42.1.120"],"URL":"https:\/\/doi.org\/10.1136\/gut.42.1.120","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}