{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:50:46Z","timestamp":1764996646210,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,7,31]]},"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Arteriovenous malformations of the liver in Osler\u2019s disease may present as high output cardiac failure. A few case reports suggested that treatment with arterial embolisation may have beneficial effects in such patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To investigate the efficacy and safety of this treatment modality in a prospective pilot study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and methods<\/jats:italic>\n                    \u2014Four women and one man (aged 39\u201359 years) with the dominant hepatic manifestation of Osler\u2019s disease presented with symptoms of cardiac failure and elevated cardiac output. Arteriovenous malformations were treated in three to five sessions with arterial embolisation using coils. The outcome was analysed by measurement of cardiac output and scoring of clinical symptoms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Embolisation was technically feasible in all patients and adequate occlusion of vascular malformations was achieved in four patients. After completion of therapy symptoms improved in four patients, while one patient suffered from abdominal pain due to cholangitis. One patient died seven months after the embolisation treatment from variceal bleeding. Mean cardiac output significantly decreased from 14.2 (range 12\u201317.3) l\/min to 8 (range 5.9\u201310.6) l\/min (p=0.043). After a median follow up of 23 months (range 7\u201350 months), three of five patients had a long lasting improvement of clinical symptoms and cardiac function.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014This first treatment series of patients with dominant hepatic involvement in Osler\u2019s disease indicates that arterial embolisation may prevent cardiac failure by significantly lowering cardiac output.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.1.123","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"123-126","source":"Crossref","is-referenced-by-count":53,"title":["Clinical outcome of transfemoral embolisation in patients with arteriovenous malformations of the liver in hereditary haemorrhagic telangiectasia (Weber-Rendu-Osler disease)"],"prefix":"10.1136","volume":"42","author":[{"given":"M","family":"Caselitz","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Wagner","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Chavan","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gebel","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Bleck","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wu","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Schlitt","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Galanski","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Manns","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, \n\nbDepartment of Radiology, \n\ncDepartment of Abdominal Surgery, Medizinische Hochschule, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"2025120520390539000_42.1.123.1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440070028004"},{"key":"2025120520390539000_42.1.123.2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80455-2"},{"key":"2025120520390539000_42.1.123.3","first-page":"363","article-title":"Clinical manifestations of hereditary hemorrhagic telangiectasia.","volume":"79","author":"Reilly","year":"1984","journal-title":"Am J Gastroenterol"},{"key":"2025120520390539000_42.1.123.4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.12.1134"},{"key":"2025120520390539000_42.1.123.5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0016-5085(93)90723-P","article-title":"Hepatic involvement in hereditary hemorrhagic telangiectasia: clinical, radiological, and hemodynamic studies of 11 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Report of 2 cases.","volume":"2","author":"G\u00f6thlin","year":"1982","journal-title":"Eur J Radiol"},{"key":"2025120520390539000_42.1.123.10","first-page":"167","article-title":"Familial occurrence of hyperdynamic circulation status due to intrahepatic fistulae in hereditary hemorrhagic telangiectasia.","volume":"35","author":"Nikolopoulos","year":"1988","journal-title":"Hepatogastroenterology"},{"key":"2025120520390539000_42.1.123.11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1021560"},{"key":"2025120520390539000_42.1.123.12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0140-6736(85)92142-7","article-title":"Therapeutic embolisation of the hepatic artery: a review of 75 procedures.","volume":"i","author":"Allison","year":"1985","journal-title":"Lancet"},{"key":"2025120520390539000_42.1.123.13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00004836-199004000-00030","article-title":"Osler-Weber-Rendu disease associated with hepatic involvement and high output heart failure.","volume":"12","author":"Bourgeois","year":"1990","journal-title":"J Clin Gastroenterol"},{"key":"2025120520390539000_42.1.123.14","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1984.00350180230033"},{"key":"2025120520390539000_42.1.123.15","doi-asserted-by":"publisher","DOI":"10.1177\/000331978703800610"},{"key":"2025120520390539000_42.1.123.16","first-page":"260","article-title":"Embolisation of hepatic arteriovenous malformations using radiolabeled and nonradiolabeled polyvinyl alcohol sponge in a patient with hereditary hemorrhagic telangiectasia: case report.","volume":"33","author":"Whiting","year":"1992","journal-title":"J Nucl Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.42.1.123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:39:15Z","timestamp":1764995955000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.42.1.123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1998,1,1]]},"published-print":{"date-parts":[[1998,1,1]]}},"alternative-id":["10.1136\/gut.42.1.123"],"URL":"https:\/\/doi.org\/10.1136\/gut.42.1.123","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}