{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:25:15Z","timestamp":1765650315783,"version":"3.48.0"},"reference-count":23,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,9,2]]},"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014In several diseases there is a relation between deficiency of neutrophil granulocytes and granulomatous lesions. Recently, in glycogen storage disease type Ib, this relation has been supported by the beneficial effect of treatment of enteritis with granulocyte-macrophage colony stimulating factor.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u2014To investigate whether chronic granulomatous disease could be treated according to the same principle.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and methods<\/jats:italic>\n                    \u2014Inflammatory lesions were monitored in two brothers with chronic granulomatous disease demonstrated by very low superoxide production in neutrophil granulocytes. The two patients were treated with recombinant human granulocyte colony stimulating factor on three occasions when the disease was active.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014In one patient, remission of an inflamed stenosis of the colon sigmoideum was shown by granulocyte scintigraphy after one month of treatment with granulocyte colony stimulating factor. In the other patient, remission of colon disease and later of a non-malignant tumour in the right lung hilum was shown by colonoscopy and computed tomography scans respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014Remission of inflammatory lesions in two brothers with chronic granulomatous disease was induced by granulocyte colony stimulating factor on three occasions. The mechanism for this effect is not known. The result is similar to the response found in patients with leucocyte deficiency due to glycogen storage disease type Ib.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.1.127","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"127-130","source":"Crossref","is-referenced-by-count":40,"title":["Treatment of enteritis in chronic granulomatous disease with granulocyte colony stimulating factor"],"prefix":"10.1136","volume":"42","author":[{"given":"B","family":"Myrup","sequence":"first","affiliation":[{"name":"aDepartment of Medicine A, Section of Gastroenterology, Rigshospitalet, \n\nbDepartment of Paediatrics, Hvidovre Hospital, University Hospital of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N H","family":"Valerius","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine A, Section of Gastroenterology, Rigshospitalet, \n\nbDepartment of Paediatrics, Hvidovre Hospital, University Hospital of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P B","family":"Mortensen","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine A, Section of Gastroenterology, Rigshospitalet, \n\nbDepartment of Paediatrics, Hvidovre Hospital, University Hospital of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"2025121310213456000_42.1.127.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197403142901104"},{"key":"2025121310213456000_42.1.127.2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jlb.51.2.164","article-title":"Chronic granulomatous disease with partial deficiency of cytochrome b558 and incomplete respiratory burst: variant of the X-linked, cytochrome b558-negative form of the disease.","volume":"51","author":"Ross","year":"1992","journal-title":"J Leukoc Biol"},{"key":"2025121310213456000_42.1.127.3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1182\/blood.V33.6.813.813","article-title":"Defective bactericidal activity of monocytes in fatal granulomatous disease.","volume":"33","author":"Rodey","year":"1969","journal-title":"Blood"},{"key":"2025121310213456000_42.1.127.4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0140-6736(78)91445-9","article-title":"Absence of a newly described cytochrome bfrom neutrophils of patients with chronic granulomatous disease.","volume":"2","author":"Segal","year":"1978","journal-title":"Lancet"},{"key":"2025121310213456000_42.1.127.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80975-9"},{"key":"2025121310213456000_42.1.127.6","first-page":"25","article-title":"Inheritance of chronic granulomatous disease.","volume":"3. 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