{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:00:41Z","timestamp":1767859241318,"version":"3.49.0"},"reference-count":0,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>\u2014Human chorionic gonadotropin (hCG) is normally produced and secreted by trophoblastic cells during pregnancy and from gestational trophoblastic neoplasms. It is also detected in ovarian, stomach, and colon adenocarcinomas, as well as in squamous cell carcinoma of the oesophagus. Recently, interest in its role in the pathogenesis of tumours has been enlivened after the presence of \u03b2hCG in the cell membrane of several malignant cells was shown in vitro.<\/jats:p><jats:p><jats:italic>Aims<\/jats:italic>\u2014To investigate the circulating concentrations of \u03b2hCG in patients with exocrine pancreatic adenocarcinoma and to examine its potential prognostic value.<\/jats:p><jats:p><jats:italic>Patients<\/jats:italic>\u2014Thirty six patients with exocrine pancreatic adenocarcinoma, 12 patients with chronic pancreatitis, and 21 healthy volunteers were studied.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>\u2014\u03b2hCG serum concentrations were detected by the application of a radioimmunoassay technique.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>\u2014Fifteen of 36 patients with pancreatic adenocarcinoma and only one patient with chronic pancreatitis had detectable plasma concentrations of \u03b2hCG (p&lt;0.01). The patients with circulating serum titres of \u03b2hCG had a worse outcome compared with the group of \u03b2hCG negative patients: the difference was statistically significant (p=0.01).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>\u2014More than 40% of pancreatic exocrine tumours produce \u03b2hCG and its production is correlated with an adverse effect on outcome.<\/jats:p>","DOI":"10.1136\/gut.42.1.88","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T16:46:12Z","timestamp":1277916372000},"page":"88-91","source":"Crossref","is-referenced-by-count":40,"title":["Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma"],"prefix":"10.1136","volume":"42","author":[{"given":"K N","family":"Syrigos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Fyssas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Konstandoulakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K J","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Milingos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Peveretos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B C","family":"Golematis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,1,1]]},"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.42.1.88","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:32:11Z","timestamp":1601091131000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.42.1.88"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1998,1,1]]},"published-print":{"date-parts":[[1998,1,1]]}},"alternative-id":["10.1136\/gut.42.1.88"],"URL":"https:\/\/doi.org\/10.1136\/gut.42.1.88","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}