{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:54Z","timestamp":1791925254508,"version":"4.3.4"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,6,24]]},"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Impeded flow of pancreatic juice due to mechanical obstruction of the pancreatic duct in patients with cancer of the pancreatic head region causes exocrine pancreatic insufficiency with steatorrhoea and creatorrhoea. This may contribute to the profound weight loss that often occurs in these patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To investigate whether pancreatic enzyme replacement therapy prevents this weight loss.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients<\/jats:italic>\n                    \u2014Twenty one patients with unresectable cancer of the pancreatic head region with suspected pancreatic duct obstruction, a biliary endoprosthesis in situ, and a Karnofsky performance status greater than 60.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Randomised double blind trial of eight weeks with either placebo or high dose enteric coated pancreatin enzyme supplementation. All patients received dietary counselling.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014The mean difference in the percentage change of body weight was 4.9% (p=0.02, 95% confidence interval for the difference: 0.9 to 8.9). Patients on pancreatic enzymes gained 1.2% (0.7 kg) body weight whereas patients on placebo lost 3.7% (2.2 kg). The fat absorption coefficient in patients on pancreatic enzymes improved by 12% whereas in placebo patients it dropped by 8% (p=0.13, 95% confidence interval for the difference: \u20136 to 45). The daily total energy intake was 8.42 MJ in patients on pancreatic enzymes and 6.66 MJ in placebo patients (p=0.04, 95% confidence interval for the difference: 0.08 to 3.44).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Weight loss in patients with unresectable cancer of the pancreatic head region and occlusion of the pancreatic duct can be prevented, at least for the period immediately after insertion of a biliary endoprosthesis, by high dose enteric coated pancreatin enzyme supplementation in combination with dietary counselling.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.1.92","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"92-96","source":"Crossref","is-referenced-by-count":146,"title":["Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region"],"prefix":"10.1136","volume":"42","author":[{"given":"M J","family":"Bruno","sequence":"first","affiliation":[{"name":"aDivision of Gastroenterology and Hepatology, \n\nb\nDepartment of Dietetics, \n\ncDepartment of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E B","family":"Haverkort","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology and Hepatology, \n\nb\nDepartment of Dietetics, \n\ncDepartment of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Tijssen","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology and Hepatology, \n\nb\nDepartment of Dietetics, \n\ncDepartment of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G N J","family":"Tytgat","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology and Hepatology, \n\nb\nDepartment of Dietetics, \n\ncDepartment of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology and Hepatology, \n\nb\nDepartment of Dietetics, \n\ncDepartment of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"2025120519452755000_42.1.92.1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/00000658-198910000-00015","article-title":"Experience with 647 consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct.","volume":"210","author":"Michelassi","year":"1989","journal-title":"Ann Surg"},{"key":"2025120519452755000_42.1.92.2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871101)60:9<2284::AID-CNCR2820600930>3.0.CO;2-V"},{"key":"2025120519452755000_42.1.92.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850715)56:2<397::AID-CNCR2820560232>3.0.CO;2-I"},{"key":"2025120519452755000_42.1.92.4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00005792-195902000-00003","article-title":"Carcinoma of the pancreas.","volume":"38","author":"Gullick","year":"1959","journal-title":"Medicine"},{"key":"2025120519452755000_42.1.92.5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850101)55:1+<225::AID-CNCR2820551304>3.0.CO;2-7"},{"key":"2025120519452755000_42.1.92.6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861015)58:8+<1867::AID-CNCR2820581413>3.0.CO;2-A"},{"key":"2025120519452755000_42.1.92.7","doi-asserted-by":"crossref","unstructured":"Heber D, Tchelonedyian NS. 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