{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:15:55Z","timestamp":1789884955891,"version":"4.0.1"},"reference-count":39,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,9,30]]},"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Offspring with a family history of Crohn\u2019s disease have an earlier age of onset than their parents. This might be due to genetic anticipation, characterised by earlier and\/or more severe disease in subsequent generations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To investigate the possibility of genetic anticipation in affected parent-child pairs with Crohn\u2019s disease from France and Belgium.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and methods<\/jats:italic>\n                    \u2014In a cohort of 160 multiply affected families with Crohn\u2019s disease, 57 parent-first affected child pairs were detected. Clinical characteristics (age at diagnosis, disease extent, and type) of both parents and children were registered and compared.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Children were younger than their parents at diagnosis in 48\/57 (84%) pairs. The median age at diagnosis was 16 years younger in children than in parents (p&lt;0.0001). However, the difference was related to the age at diagnosis in the parents and was not present in 12 parent-child pairs with an early age at diagnosis for the parents. In most cases, disease extent and type were not considered more severe in children than in parents. Parental sex affected neither age at diagnosis nor extent and type of disease in children.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014Patients in the second affected generation acquire their disease at an earlier time in life in some but not all familial cases of Crohn\u2019s disease. Several explanations including genetic anticipation and environmental factors might explain this phenomenon.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.2.170","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"170-174","source":"Crossref","is-referenced-by-count":53,"title":["Anticipation in familial Crohn\u2019s disease"],"prefix":"10.1136","volume":"42","author":[{"given":"B","family":"Grandbastien","sequence":"first","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Peeters","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Franchimont","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gower-Rousseau","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Speckel","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rutgeerts","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bela\u00efche","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cortot","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Vlietinck","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-F","family":"Colombel","sequence":"additional","affiliation":[{"name":"aRegistre des Maladies Inflammatoires du Tube Digestif du Nord-Ouest de la France (EPIMAD), Service D\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, CH et U Lille, France, \n\nbDepartment of Gastroenterology, University of Leuven, Belgium, \n\ncService d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Li\u00e8ge, Belgium, \n\ndGenetic Epidemiology, Department of Human Genetics, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,2,1]]},"reference":[{"key":"2025121222594413000_42.2.170.1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780563"},{"key":"2025121222594413000_42.2.170.2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780560"},{"key":"2025121222594413000_42.2.170.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.5.738"},{"key":"2025121222594413000_42.2.170.4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1053\/gast.1996.v111.pm8780562","article-title":"Familial aggregation in Crohn\u2019s disease: increased age adjusted risk and concordance in clinical 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