{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:03:45Z","timestamp":1791205425766,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,6,24]]},"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background and aims<\/jats:italic>\n                    \u2014Mucin glycoproteins play a key role in the normal function of the epithelium lining the gastrointestinal tract. The expression of mucin genes,\n                    <jats:italic>MUC 3, 4, 5AC, 5B, 6, 7<\/jats:italic>\n                    , and\n                    <jats:italic>8<\/jats:italic>\n                    in human fetal tissues was examined to establish the localisation and age of onset of expression of each mucin gene during human development.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Mucin gene expression was assayed by mRNA in situ hybridisation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Expression of\n                    <jats:italic>MUC3<\/jats:italic>\n                    was detected in the small intestine and colon from 13 weeks gestation onwards and at low levels in the main pancreatic duct at 13 weeks only.\n                    <jats:italic>MUC4<\/jats:italic>\n                    expression was seen at a low level in the colonic epithelium from 13 weeks of gestation but not elsewhere in the gastrointestinal tract. MUC5AC mRNA was detected in the colon at 17 weeks and at high levels in the stomach at 23 weeks.\n                    <jats:italic>MUC6<\/jats:italic>\n                    transcripts were evident in the pancreatic ducts from 13 weeks of gestation and at high levels in the stomach at 23 weeks.\n                    <jats:italic>MUC5B<\/jats:italic>\n                    ,\n                    <jats:italic>MUC7<\/jats:italic>\n                    , and\n                    <jats:italic>MUC8<\/jats:italic>\n                    transcripts were not detected.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Mucin genes are expressed from the early mid-trimester of gestation in the developing human fetal gastrointestinal tract.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.2.220","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"220-226","source":"Crossref","is-referenced-by-count":79,"title":["Developmental expression of mucin genes in the human gastrointestinal system"],"prefix":"10.1136","volume":"42","author":[{"given":"C J","family":"Reid","sequence":"first","affiliation":[{"name":"Paediatric Molecular Genetics, Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Harris","sequence":"additional","affiliation":[{"name":"Paediatric Molecular Genetics, Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,2,1]]},"reference":[{"key":"2025120518581355000_42.2.220.1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91580-6"},{"key":"2025120518581355000_42.2.220.2","first-page":"471","article-title":"Diversity of the peptide moiety of human airway mucins.","volume":"27","author":"Crepin","year":"1991","journal-title":"Biorheology"},{"key":"2025120518581355000_42.2.220.3","doi-asserted-by":"crossref","unstructured":"Dufosse J, Porchet N, Audie JP, et al.Bioche. 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