{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:04:33Z","timestamp":1790744673069,"version":"4.1.0"},"reference-count":31,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,9,23]]},"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Previous studies have failed to identify manometric patterns of gastrointestinal motor activity that can distinguish dyspepsia from health.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To test the hypothesis that the combined use of prolonged, ambulatory, antrojejunal manometry and computer aided analysis in patients selected for the severity of their symptoms could reveal new insights into gastrointestinal motor activity in patients with severe motility-like dyspesia\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Twenty four hour antrojejunal ambulatory manometry was performed in 14 patients and 10 healthy volunteers. Parameters characterising digestive and fasted motility were obtained by a validated computer program and visual analysis. Scoring systems quantified the degree of dysmotility as well as the severity of symptoms. Gastric emptying times were measured in each patient.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014There was a high prevalence of antral and jejunal dysmotility both during the interdigestive period (71% of patients) and in the postprandial period (78%). During the interdigestive period there was a reduced incidence of antral and jejunal phases, a larger contribution of phase 2 during migrating motor complex cycles, and aberrant configuration of jejunal phase 3 in 29% of patients. Postprandially, the most frequent finding was antral (29% of patients) or jejunal (29%) hypomotility or hypermotility. Minute rhythm was present both during the postprandial (29% of patients) and the interdigestive period (21%). There was no positive correlation between symptom scores, gastric half emptying times, or motility scores.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014Even with the use of prolonged recordings and advanced computer aided analysis, it is not possible to identify a specific motor pattern which can discriminate patients with severe motility-like dyspepsia from those with other diseases or even healthy individuals. Clinical symptoms or gastric half emptying times are poor predictors of gastrointestinal dysmotility in patients with functional dyspepsia.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.2.235","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"235-242","source":"Crossref","is-referenced-by-count":83,"title":["Ambulatory gastrojejunal manometry in severe motility-like dyspepsia: lack of correlation between dysmotility, symptoms, and gastric emptying"],"prefix":"10.1136","volume":"42","author":[{"given":"A","family":"Wilmer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Van Cutsem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Andrioli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Coremans","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,2,1]]},"reference":[{"key":"2025121310263007000_42.2.235.1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0016-5085(85)80083-4","article-title":"Manometric evaluation of functional upper gut symptoms.","volume":"88","author":"Malagelada","year":"1985","journal-title":"Gastroenterology"},{"key":"2025121310263007000_42.2.235.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.1.54"},{"key":"2025121310263007000_42.2.235.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.2.184"},{"key":"2025121310263007000_42.2.235.4","first-page":"615","article-title":"Upper gut motility and perception in functional dyspepsia.","volume":"4","author":"Mearin","year":"1992","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121310263007000_42.2.235.5","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199002000-00006"},{"key":"2025121310263007000_42.2.235.6","first-page":"109","article-title":"Antroduodenal manometry: 24-hour ambulatory monitoring versus short-term stationary manometry in patients with functional dyspepsia.","volume":"7","author":"Jebbink","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121310263007000_42.2.235.7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.5.694"},{"key":"2025121310263007000_42.2.235.8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/00365521.1990.12067094","article-title":"Digital ambulatory monitoring of small bowel motility.","volume":"25","author":"Lindbergh","year":"1990","journal-title":"Scand J Gastroenterol"},{"key":"2025121310263007000_42.2.235.9","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/0016-5085(90)90335-X","article-title":"Prolonged ambulatory recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome.","volume":"98","author":"Kellow","year":"1990","journal-title":"Gastroenterology"},{"key":"2025121310263007000_42.2.235.10","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/BF01537575","article-title":"Digital ambulatory manometry of the small intestine in healthy adults. 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