{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:37:37Z","timestamp":1783053457893,"version":"3.54.6"},"reference-count":47,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,7,31]]},"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background\u2014<\/jats:italic>\n                    The effect of histamine H\n                    <jats:sub>2<\/jats:sub>\n                    receptor antagonists on gastric emptying is controversial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims\u2014<\/jats:italic>\n                    To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and methods\u2014<\/jats:italic>\n                    Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (EGG), and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of fasting manometry and EGG recording, subjects received either intravenous saline, ranitidine, or famotidine, followed by another 30 minutes recording and then three hours of postprandial recording after ingestion of a radiolabelled meal. Images were obtained every 10\u201315 minutes for three hours to measure gastric emptying and assess antral contractility. Similar testing was performed after omeprazole 20 mg daily for one week.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results\u2014<\/jats:italic>\n                    Fasting antral phase III migrating motor complexes (MMCs) were more common after ranitidine (9\/15 subjects, 60%), famotidine (12\/15, 80%), and omeprazole (8\/12, 67%) compared with placebo (4\/14, 29%; p&lt;0.05). Postprandially, ranitidine, famotidine, and omeprazole slowed gastric emptying, increased the amplitude of DAS contractions, increased the EGG power, and increased the antral manometric motility index.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions\u2014<\/jats:italic>\n                    Suppression of gastric acid secretion with therapeutic doses of gastric acid suppressants is associated with delayed gastric emptying but increased antral motility.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.2.243","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"243-250","source":"Crossref","is-referenced-by-count":164,"title":["Effect of gastric acid suppressants on human gastric motility"],"prefix":"10.1136","volume":"42","author":[{"given":"H P","family":"Parkman","sequence":"first","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L C","family":"Urbain","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L C","family":"Knight","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Brown","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Trate","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Miller","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A H","family":"Maurer","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"Fisher","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine and Nuclear Medicine Section, Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,2,1]]},"reference":[{"key":"2025121221134307000_42.2.243.1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2036.1987.tb00640.x","article-title":"A comparative study of the effect of cimetidine and ranitidine on the rate of gastric emptying of liquid and solid test meals in man.","volume":"1","author":"Houghton","year":"1987","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121221134307000_42.2.243.2","first-page":"916","article-title":"Ranitidine and total gastric emptying 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