{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:10:02Z","timestamp":1791900602246,"version":"4.3.4"},"reference-count":48,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,6,24]]},"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic\/carcinogenic adduct, and thiobarbituric acid reactive substances (TBARS), as an indirect measure of free radical mediated damage, were determined in biopsy specimens from patients undergoing endoscopy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients<\/jats:italic>\n                    \u2014Eighty eight patients were divided into histological subgroups as follows: 27 with chronic non-atrophic gastritis, 41 with atrophic gastritis, six with gastric cancer, and 14 unaffected controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Intestinal metaplasia,\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection, and disease activity were semiquantitatively scored. 8OHdG concentrations were assessed by HPLC with electrochemical detection, and TBARS concentrations were fluorimetrically assayed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u20148OHdG concentrations (mean number of adducts\/10\n                    <jats:sup>5<\/jats:sup>\n                    dG residues) were significantly higher in chronic atrophic gastritis (p=0.0009). Significantly higher concentrations were also detected in the presence of severe disease activity (p=0.02), intestinal metaplasia (p=0.035), and\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection (p=0.001). TBARS concentrations were also higher in atrophic gastritis, though not significantly so. In a multiple logistic regression analysis, 8OHdG concentrations correlated best with the presence and severity of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection (\n                    <jats:italic>r<\/jats:italic>\n                    =0.53, p=0.002).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Chronic gastritis is characterised by the accumulation of oxidative DNA damage with mutagenic and carcinogenic potential.\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection is the major determinant for DNA adduct formation.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.3.351","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"351-356","source":"Crossref","is-referenced-by-count":209,"title":["Oxidative DNA damage accumulation 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Degan","sequence":"additional","affiliation":[{"name":"aCattedra Malattie Apparato Digerente, Istituto Medicina Interna, \n\nbCattedra Biochimica Clinica, Istituto Medicina di Laboratorio, Universita di Padova, Italy, \n\ncIstituto Nazionale per la Ricerca sul Cancro, Genova, Italy, \n\ndCattedra di Istochimica ed Immuno Istochimica Patologica, Istituto di Anatomia Patologica, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rugge","sequence":"additional","affiliation":[{"name":"aCattedra Malattie Apparato Digerente, Istituto Medicina Interna, \n\nbCattedra Biochimica Clinica, Istituto Medicina di Laboratorio, Universita di Padova, Italy, \n\ncIstituto Nazionale per la Ricerca sul Cancro, Genova, Italy, \n\ndCattedra di Istochimica ed Immuno Istochimica Patologica, Istituto di Anatomia Patologica, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Di Mario","sequence":"additional","affiliation":[{"name":"aCattedra Malattie Apparato Digerente, Istituto Medicina Interna, \n\nbCattedra Biochimica Clinica, Istituto Medicina di Laboratorio, Universita di Padova, Italy, \n\ncIstituto Nazionale per la Ricerca sul Cancro, Genova, Italy, \n\ndCattedra di Istochimica ed Immuno Istochimica Patologica, Istituto di Anatomia Patologica, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bonvicini","sequence":"additional","affiliation":[{"name":"aCattedra Malattie Apparato Digerente, Istituto Medicina Interna, \n\nbCattedra Biochimica Clinica, Istituto Medicina di Laboratorio, Universita di Padova, Italy, \n\ncIstituto Nazionale per la Ricerca sul Cancro, Genova, Italy, \n\ndCattedra di Istochimica ed Immuno Istochimica Patologica, Istituto di Anatomia Patologica, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Naccarato","sequence":"additional","affiliation":[{"name":"aCattedra Malattie Apparato Digerente, Istituto Medicina Interna, \n\nbCattedra Biochimica Clinica, Istituto Medicina di Laboratorio, Universita di Padova, Italy, \n\ncIstituto Nazionale per la Ricerca sul Cancro, Genova, Italy, \n\ndCattedra di Istochimica ed Immuno Istochimica Patologica, Istituto di Anatomia Patologica, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,3,1]]},"reference":[{"key":"2025121221201231000_42.3.351.1","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process.","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer 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