{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:53:57Z","timestamp":1791158037278,"version":"4.1.0"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,9,5]]},"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Selective immunoglobulin A (IgA) deficiency (SIgAD) is associated with coeliac disease (CD).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u2014To make a retrospective study of the association of SIgAD with CD in Italy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Hospital medical records of 2098 patients consecutively diagnosed as having CD were reviewed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Of 2098 patients with CD, 54 (2.6%) had SIgAD, representing a 10\u201316-fold increase over that in the population in general. This increase was not influenced by age or geographical factors. Patients with SIgAD had a higher incidence of silent forms (7\/54, 13%), recurrent infections (16\/54, 29.6%), and atopic diseases (7\/54, 13%) than those without. The association with autoimmune and malignant diseases and the outcome after eating a gluten free diet were similar in patients with or without SIgAD. In all patients with SIgAD, antibodies for IgA gliadin and endomysium were absent, but serum levels of IgG anti-gliadin antibodies were high in almost all of them (51\/54).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Serum IgA should be measured in order to be able to interpret negative results for IgA anti-gliadin antibodies and anti-endomysial antibodies in patients being screened for CD. Since some patients with CD and SIgAD may be negative for IgG anti-gliadin antibodies, an intestinal biopsy should be performed in all suspected cases.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.3.362","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"362-365","source":"Crossref","is-referenced-by-count":238,"title":["Prevalence and clinical features of selective immunoglobulin A deficiency in coeliac disease: an Italian multicentre study"],"prefix":"10.1136","volume":"42","author":[{"given":"F","family":"Cataldo","sequence":"first","affiliation":[{"name":"Clinica Pediatrica R, Via Lancia di Brolo 10B, 90135 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Marino","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica R, Via Lancia di Brolo 10B, 90135 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ventura","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica R, Via Lancia di Brolo 10B, 90135 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Bottaro","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica R, Via Lancia di Brolo 10B, 90135 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G R","family":"Corazza","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica R, Via Lancia di Brolo 10B, 90135 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) \u201cClub del Tenue\u201d Working Groups on Coeliac Disease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,3,1]]},"reference":[{"key":"2025121222372742000_42.3.362.1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209000089"},{"key":"2025121222372742000_42.3.362.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63329-7"},{"key":"2025121222372742000_42.3.362.3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1055\/s-2008-1033999","article-title":"Selective deficiency of immunoglobulin A.","volume":"197","author":"Savilahti","year":"1985","journal-title":"Klin Padiatr"},{"key":"2025121222372742000_42.3.362.4","first-page":"248","article-title":"IgA deficiency.","volume":"19","author":"Klemola","year":"1987","journal-title":"Annals of Clinical Research"},{"key":"2025121222372742000_42.3.362.5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0140-6736(71)92301-4","article-title":"Gluten enteropathy associated with selective IgA deficiency.","volume":"2","author":"Mawhinney","year":"1971","journal-title":"Lancet"},{"key":"2025121222372742000_42.3.362.6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.46.249.665"},{"key":"2025121222372742000_42.3.362.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1970.tb15545.x"},{"key":"2025121222372742000_42.3.362.8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"2025121222372742000_42.3.362.9","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1651-2227.1991.tb11952.x","article-title":"Clinical manifestations in selective IgA deficiency in childhood. 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The basic measures, concepts and estimation procedures.","volume":"19","author":"Green","year":"1982","journal-title":"Tissue Antigens"},{"key":"2025121222372742000_42.3.362.13","first-page":"7","article-title":"Biologia e clinica del deficit di IgA in pediatria.","volume":"7","author":"De Martino","year":"1992","journal-title":"Rivista Italiana di Infettivologia Pediatrica"},{"key":"2025121222372742000_42.3.362.14","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1651-2227.1995.tb13583.x","article-title":"Coeliac disease and insulin dependent diabetes mellitus: a casual association?","volume":"84","author":"Pocecco","year":"1995","journal-title":"Acta Paediatr"},{"key":"2025121222372742000_42.3.362.15","unstructured":"Ventura A, Magazzu\u2019 G. Autoimmune disorders in coeliac disease. Seventh International Symposium on Coeliac Disease. 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