{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:43:17Z","timestamp":1791088997600,"version":"4.1.0"},"reference-count":34,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,11,6]]},"published-print":{"date-parts":[[1998,4,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Abnormal visceral mechanosensory and vagal function may play a role in the development of functional gastrointestinal disorders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To assess whether vagal efferent and afferent function is linked with small intestinal mechanosensory function.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014In seven patients with functional dyspepsia, six patients with a history of Billroth I gastrectomy and\/or vagotomy, and seven healthy controls, intestinal perception thresholds were tested by a randomised ramp distension procedure performed with a barostat device. On a separate day, an insulin hypoglycaemia test was performed to assess the plasma levels of pancreatic polypeptide (PP) in response to hypoglycaemia, as a test of efferent vagal function.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014First perception of intestinal balloon distension occurred at significantly lower pressures in patients with functional dyspepsia (median 19.3, range 14.7\u201325.3 mm Hg) compared with healthy controls (median 26.0, range 21.7\u201343.7 mm Hg, p&lt;0.01). Sensory thresholds were significantly lower in patients after gastrectomy (median 12.2, range 8.0\u201314.7 mm Hg, p&lt;0.05 versus all others). In healthy controls and patients with functional dyspepsia, insulin hypoglycaemia significantly (p&lt;0.001) increased plasma PP levels. However, only two out of seven patients with functional dyspepsia had a more than twofold increase in PP values whereas all healthy controls had a more than twofold increase in PP levels after insulin hypoglycaemia (p&lt;0.05). In contrast, there was no significant PP response in the gastrectomised patients (median 2%, range \u221210 to +23%). PP responses and visceral sensory thresholds were significantly correlated (\n                    <jats:italic>r<\/jats:italic>\n                    =0.65, p&lt;0.002).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014The diminished PP response after insulin hypoglycaemia indicates disturbed efferent vagal function in a subgroup of patients with functional dyspepsia. The data also suggest that the intact vagal nerve may exert an antinociceptive visceral effect.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.4.501","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"501-506","source":"Crossref","is-referenced-by-count":106,"title":["Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia"],"prefix":"10.1136","volume":"42","author":[{"given":"G","family":"Holtmann","sequence":"first","affiliation":[{"name":"aDivision of Gastroenterology, \n\nbDivision of Endocrinology, University of Essen, Germany, \n\ncDepartment of Medicine, University of Sydney, Nepean Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Goebell","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology, \n\nbDivision of Endocrinology, University of Essen, Germany, \n\ncDepartment of Medicine, University of Sydney, Nepean Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Jockenhoevel","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology, \n\nbDivision of Endocrinology, University of Essen, Germany, \n\ncDepartment of Medicine, University of Sydney, Nepean Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N J","family":"Talley","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology, \n\nbDivision of Endocrinology, University of Essen, Germany, \n\ncDepartment of Medicine, University of Sydney, Nepean Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"2025121302091982000_42.4.501.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307517"},{"key":"2025121302091982000_42.4.501.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300087"},{"key":"2025121302091982000_42.4.501.3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90726-2"},{"key":"2025121302091982000_42.4.501.4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.2.125"},{"key":"2025121302091982000_42.4.501.5","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0016-5085(90)90332-U","article-title":"Tolerance of rectosigmoid distension in irritable bowel syndrome.","volume":"90","author":"Whitehead","year":"1990","journal-title":"Gastroenterology"},{"key":"2025121302091982000_42.4.501.6","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90809-5"},{"key":"2025121302091982000_42.4.501.7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90086-8"},{"key":"2025121302091982000_42.4.501.8","first-page":"G595","article-title":"Reflex gastric relaxation in response to distension of the duodenum.","volume":"252","author":"De Ponti","year":"1987","journal-title":"Am J Physiol"},{"key":"2025121302091982000_42.4.501.9","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90536-3"},{"key":"2025121302091982000_42.4.501.10","first-page":"485","article-title":"Impaired small intestinal peristaltic reflexes and sensory thresholds are independent functional disturbances in patients with chronic unexplained dyspepsia.","volume":"91","author":"Holtmann","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025121302091982000_42.4.501.11","first-page":"954","article-title":"Functional dyspepsia and irritable bowel syndrome: is there a common pathophysiological basis?","volume":"92","author":"Holtmann","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121302091982000_42.4.501.12","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)70018-S"},{"key":"2025121302091982000_42.4.501.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91792-2"},{"key":"2025121302091982000_42.4.501.14","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199410000-00014"},{"key":"2025121302091982000_42.4.501.15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-8-671"},{"key":"2025121302091982000_42.4.501.16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087563"},{"key":"2025121302091982000_42.4.501.17","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0016-5085(85)80083-4","article-title":"Manometric evaluation of functional upper gut symptoms.","volume":"88","author":"Malagelada","year":"1985","journal-title":"Gastroenterology"},{"key":"2025121302091982000_42.4.501.18","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088548"},{"key":"2025121302091982000_42.4.501.19","doi-asserted-by":"publisher","DOI":"10.2307\/2280779"},{"key":"2025121302091982000_42.4.501.20","unstructured":"SAS Institute Inc (1988) SAS\/STAT user\u2019s guide, Release 6.03. 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