{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:54:27Z","timestamp":1771559667369,"version":"3.50.1"},"reference-count":36,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,12,19]]},"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:p>\n                  <jats:italic>Background<\/jats:italic>\u2014Although chemokines have been suggested to play an important role in <jats:italic>Helicobacter pylori<\/jats:italic>associated gastritis, few studies have investigated the role of chemokines other than interleukin 8 (IL-8) in gastric mucosa.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Aims<\/jats:italic>\u2014To investigate the expression and production patterns of various chemokines using gastric biopsy specimens.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Methods<\/jats:italic>\u2014In 192 patients, expression patterns of C-X-C chemokines (IL-8 and growth regulated \u03b1 (GRO\u03b1)) and C-C chemokines (regulated on activation, normal T cell expressed and presumably secreted (RANTES), monocyte chemotactic and activating factor (MCAF), macrophage inflammatory protein 1\u03b1 (MIP-1\u03b1), and MIP-1\u03b2) were examined using reverse transcription polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA).<jats:italic>cagA <\/jats:italic>gene was identified using PCR.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Results<\/jats:italic>\u2014<jats:italic>H pylori<\/jats:italic> infection was associated with increased rates of expression of mRNA for IL-8, GRO\u03b1, RANTES, and MIP-1\u03b1 and with increased levels of mucosal IL-8 and GRO\u03b1. IL-8 and GRO\u03b1 levels correlated with the density of <jats:italic>H pylori<\/jats:italic> in both the antrum and corpus. The levels of these chemokines correlated with cellular infiltration in the antrum but not the corpus. <jats:italic>cagA <\/jats:italic>gene positive <jats:italic>H pylori<\/jats:italic>infection was associated with increased rates of expression of mRNA for IL-8 and GRO\u03b1 and with increased levels of these chemokines.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Conclusion<\/jats:italic>\u2014<jats:italic>H pylori<\/jats:italic> infection is associated with increased expression rates and production of C-X-C chemokines (IL-8 and GRO\u03b1), but not with increased production of C-C chemokines. Although <jats:italic>H pylori<\/jats:italic> infection is associated with increased C-X-C chemokines in the antrum and corpus, there is a difference in the inflammatory response between these two areas of the stomach.<\/jats:p>","DOI":"10.1136\/gut.42.5.609","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"609-617","source":"Crossref","is-referenced-by-count":160,"title":["Chemokines in the gastric mucosa in <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1136","volume":"42","author":[{"given":"Y","family":"Yamaoka","sequence":"first","affiliation":[{"name":"aThird Department of Internal Medicine, \n\nbDepartment of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kita","sequence":"additional","affiliation":[{"name":"aThird Department of Internal Medicine, \n\nbDepartment of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kodama","sequence":"additional","affiliation":[{"name":"aThird Department of Internal Medicine, \n\nbDepartment of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Sawai","sequence":"additional","affiliation":[{"name":"aThird Department of Internal Medicine, \n\nbDepartment of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Tanahashi","sequence":"additional","affiliation":[{"name":"aThird Department of Internal Medicine, \n\nbDepartment of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kashima","sequence":"additional","affiliation":[{"name":"aThird Department of Internal Medicine, \n\nbDepartment of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Imanishi","sequence":"additional","affiliation":[{"name":"aThird Department of Internal Medicine, \n\nbDepartment of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"2025090722314860000_42.5.609.1","doi-asserted-by":"crossref","unstructured":"Blaser MJ. 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