{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:55:03Z","timestamp":1765648503688,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,12,19]]},"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    eradication therapy is routinely used for treating patients with peptic ulcer disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To assess the value of symptomatic response to\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication therapy as a marker of post-treatment\n                    <jats:italic>H pylori<\/jats:italic>\n                    status.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients and methods<\/jats:italic>\n                    \u2014One hundred and nine dyspeptic patients with active duodenal or gastric ulceration associated with\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection had their symptoms measured by a validated questionnaire before and three months following\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication therapy. The symptomatic response was compared with post-treatment\n                    <jats:italic>H pylori<\/jats:italic>\n                    status as determined by the\n                    <jats:sup>14<\/jats:sup>\n                    C urea breath test.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014An eradication rate of 84% was achieved. Of the 92 patients eradicated of\n                    <jats:italic>H pylori<\/jats:italic>\n                    , 47% experienced complete or near complete resolution of dyspepsia. Of the 17 patients in whom the infection was not eradicated, only one (6%) experienced resolution of dyspepsia. Resolution of dyspepsia was therefore a powerful predictor of eradication of\n                    <jats:italic>H pylori<\/jats:italic>\n                    with a predictive value of 98%. In contrast, persistence of dyspepsia was a weak predictor of persisting infection with a predictive value of only 25%. Excluding patients with endoscopic evidence of coexisting oesophagitis and\/or retrosternal discomfort or reflux at initial presentation did not increase the predictive value of persisting dyspepsia for persisting infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Complete resolution of dyspeptic symptoms is a powerful predictor of eradication of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection in ulcer patients. Persistence of symptoms is a weak predictor of persisting infection and patients with persisting dyspepsia must have their\n                    <jats:italic>H pylori<\/jats:italic>\n                    status rechecked to guide future management.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.5.618","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"618-622","source":"Crossref","is-referenced-by-count":29,"title":["Assessment of symptomatic response as predictor of\n                    <i>Helicobacter pylori<\/i>\n                    status following eradication therapy in patients with ulcer"],"prefix":"10.1136","volume":"42","author":[{"given":"K E L","family":"McColl","sequence":"first","affiliation":[{"name":"University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"El-Nujumi","sequence":"additional","affiliation":[{"name":"University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L S","family":"Murray","sequence":"additional","affiliation":[{"name":"University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"El-Omar","sequence":"additional","affiliation":[{"name":"University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dickson","sequence":"additional","affiliation":[{"name":"University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Kelman","sequence":"additional","affiliation":[{"name":"University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T E","family":"Hilditch","sequence":"additional","affiliation":[{"name":"University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"2025121309500795000_42.5.618.1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00042737-199610000-00006","article-title":"The Glasgow Dyspepsia Severity Score\u2014a tool for the global assessment of dyspepsia.","volume":"8","author":"El-Omar","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121309500795000_42.5.618.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.9.973"},{"key":"2025121309500795000_42.5.618.3","first-page":"200","article-title":"Rapid urease test in the management of Campylobacter pyloridis-associated gastritis.","volume":"82","author":"Marshall","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"2025121309500795000_42.5.618.4","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90142-Y"},{"key":"2025121309500795000_42.5.618.5","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90373-9"},{"key":"2025121309500795000_42.5.618.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6779.749"},{"key":"2025121309500795000_42.5.618.7","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90287-F"},{"key":"2025121309500795000_42.5.618.8","doi-asserted-by":"publisher","DOI":"10.3109\/00365529008997594"},{"key":"2025121309500795000_42.5.618.9","first-page":"A319","article-title":"Recurrent symptoms after Helicobacter pylori treatment, endoscopic and microbiological findings [abstract].","volume":"112","author":"Vakil","year":"1997","journal-title":"Gastroenterology"},{"key":"2025121309500795000_42.5.618.10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2036.1995.tb00410.x","article-title":"Helicobacter pylori eradication in a clinical setting: success rates and the effect on the quality of life in peptic ulcer.","volume":"9","author":"Reilly","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121309500795000_42.5.618.11","first-page":"1539","article-title":"The prevalence of oesophagitis in patients with duodenal ulcer or ulcer-like dyspepsia.","volume":"91","author":"Boyd","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025121309500795000_42.5.618.12","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90374-7"},{"key":"2025121309500795000_42.5.618.13","doi-asserted-by":"crossref","unstructured":"Solcia E, Villani L, Fiocca R, et al. Effects of eradication of Helicobacter pylori on gastritis in duodenal ulcer patients. Scand J Gastroenterol 1994;29(suppl 201):28\u201334. .","DOI":"10.3109\/00365529409105357"},{"key":"2025121309500795000_42.5.618.14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/bmj.312.7027.349","article-title":"Absence of dyspeptic symptoms as a test for Helicobacter pylori eradication.","volume":"312","author":"Phull","year":"1996","journal-title":"BMJ"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.42.5.618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:50:12Z","timestamp":1765648212000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.42.5.618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5,1]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1998,5,1]]},"published-print":{"date-parts":[[1998,5,1]]}},"alternative-id":["10.1136\/gut.42.5.618"],"URL":"https:\/\/doi.org\/10.1136\/gut.42.5.618","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1998,5,1]]}}}