{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:18Z","timestamp":1790517378587,"version":"4.1.0"},"reference-count":27,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1997,10,31]]},"published-print":{"date-parts":[[1998,6,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Hypersensitivity of gastric afferent pathways may play an aetiological role in symptoms of functional dyspepsia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To determine whether patients with severe organic dyspepsia (associated with tissue irritation\/injury) and those with functional dyspepsia (no detectable tissue irritation) differ in their perception of gastric distension and whether this difference is reflected in differences in their gastrointestinal and psychological symptoms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Perceptual thresholds, referral patterns, and gastrointestinal and psychological symptoms were compared in 23 patients with functional dyspepsia, 10 organic dyspeptics, and 15 healthy controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Fifteen (65%) functional dyspeptics and no organic dyspeptics had reduced perceptual thresholds for fullness, discomfort, or pain (odds ratio (OR) 19.56, 95% confidence interval (CI) 1.95 to 476.09, p=0.0017). Either reduced perceptual thresholds or altered referral was found in 20 (87%) functional dyspeptics and four (20%) organic dyspeptics (OR 10.0, 95% CI 1.34 to 89.54, p=0.014). During sham distension fullness, discomfort and pain were reported by healthy controls, organic dyspeptics, and functional dyspeptics. A sham response of pain but no other sensation was more frequent among functional dyspeptics (43%) than healthy controls (7%) (OR 10.77, 95% CI 1.10 to 257.35, p=0.026). Gastrointestinal and psychological symptoms and gastric compliance were similar in the functional and organic groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Alterations in the perception of gastric distension distinguishes between functional and organic dyspepsia, while symptoms do not. A total of 87% of functional dyspeptics studied had evidence of altered visceral afferent function. In this study population, psychological abnormalities or changes in compliance did not explain the findings.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.6.814","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"814-822","source":"Crossref","is-referenced-by-count":213,"title":["Symptoms and visceral perception in severe functional and organic dyspepsia"],"prefix":"10.1136","volume":"42","author":[{"given":"H","family":"Mertz","sequence":"first","affiliation":[{"name":"aCURE: Digestive Disease Research Center\/Neuroenteric Disease Program, UCLA, Los Angeles, California, USA, \n\nbDepartment of Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fullerton","sequence":"additional","affiliation":[{"name":"aCURE: Digestive Disease Research Center\/Neuroenteric Disease Program, UCLA, Los Angeles, California, USA, \n\nbDepartment of Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Naliboff","sequence":"additional","affiliation":[{"name":"aCURE: Digestive Disease Research Center\/Neuroenteric Disease Program, UCLA, Los Angeles, California, USA, \n\nbDepartment of Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Mayer","sequence":"additional","affiliation":[{"name":"aCURE: Digestive Disease Research Center\/Neuroenteric Disease Program, UCLA, Los Angeles, California, USA, \n\nbDepartment of Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,6,1]]},"reference":[{"key":"2025121312101786000_42.6.814.1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/00365528609015159","article-title":"The clinical benefit of routine upper gastrointestinal endoscopy.","volume":"21","author":"Fjosne","year":"1986","journal-title":"Scand J Gastroenterol"},{"key":"2025121312101786000_42.6.814.2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00004836-199303000-00015","article-title":"Open access endoscopy: a large scale analysis of its use in dyspeptic patients.","volume":"16","author":"Mansi","year":"1993","journal-title":"J Clin Gastroenterol"},{"key":"2025121312101786000_42.6.814.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02285210"},{"key":"2025121312101786000_42.6.814.4","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/0016-5085(90)90475-G","article-title":"Role of visceral afferent mechanisms in functional bowel disorders.","volume":"99","author":"Mayer","year":"1990","journal-title":"Gastroenterology"},{"key":"2025121312101786000_42.6.814.5","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90086-8"},{"key":"2025121312101786000_42.6.814.6","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90809-5"},{"key":"2025121312101786000_42.6.814.7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90267-8"},{"key":"2025121312101786000_42.6.814.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300087"},{"key":"2025121312101786000_42.6.814.9","unstructured":"Malagelada JR (1993) Altered visceral sensation in functional dyspepsia and related syndromes. in Basic and clinical aspects of chronic abdominal pain. eds Mayer EA Raybould HE (Elsevier, Amsterdam), pp 55\u201359."},{"key":"2025121312101786000_42.6.814.10","first-page":"A551","article-title":"Evidence for altered spinal processing of gastric afferent information in non-ulcer dyspepsia [abstract].","volume":"104","author":"Mertz","year":"1993","journal-title":"Gastroenterology"},{"key":"2025121312101786000_42.6.814.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62169-7"},{"key":"2025121312101786000_42.6.814.12","unstructured":"Derogatis LR. 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