{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:02:43Z","timestamp":1792008163821,"version":"4.4.0"},"reference-count":41,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,1,19]]},"published-print":{"date-parts":[[1998,6,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Corticotropin-releasing hormone (CRH) plays a key role in modulating intestinal motility in stressed animals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To evaluate the effect of CRH on intestinal motility in humans and to determine whether patients with irritable bowel syndrome (IBS) have an exaggerated response to CRH.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Subjects<\/jats:italic>\n                    \u2014Ten IBS patients diagnosed by Rome criteria and 10 healthy controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014CRH (2 \u03bcg\/kg) was intravenously administered during duodenal and colonic manometry and plasma adrenocorticotropic hormone (ACTH) was measured by radioimmunoassay.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014CRH induced motility of the descending colon in both groups (p&lt;0.001) and induced greater motility indexes in IBS patients than in controls (p&lt;0.05). CRH produced duodenal phase III motor activity in 80% of the subjects and duodenal dysmotility in 40% of IBS patients. Abdominal symptoms evoked by CRH in IBS patients lasted significantly longer than those in controls (p&lt;0.05). CRH induced significant increases in plasma ACTH levels in both groups (p&lt;0.001) and produced significantly higher plasma ACTH levels in IBS patients than in controls (p&lt;0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014Human intestinal motility is probably modulated by exogenous CRH. The brain-gut in IBS patients may have an exaggerated response to CRH.\n                  <\/jats:p>","DOI":"10.1136\/gut.42.6.845","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"845-849","source":"Crossref","is-referenced-by-count":325,"title":["Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome"],"prefix":"10.1136","volume":"42","author":[{"given":"S","family":"Fukudo","sequence":"first","affiliation":[{"name":"aDepartment of Psychosomatic Medicine, \n\nbDepartment of Comprehensive Medicine, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Nomura","sequence":"additional","affiliation":[{"name":"aDepartment of Psychosomatic Medicine, \n\nbDepartment of Comprehensive Medicine, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hongo","sequence":"additional","affiliation":[{"name":"aDepartment of Psychosomatic Medicine, \n\nbDepartment of Comprehensive Medicine, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,6,1]]},"reference":[{"key":"2025121306303329000_42.6.845.1","unstructured":"Malagelada J-R (1991) The gastroduodenal response to stress in man in health and functional dyspepsia. in Brain-gut interactions. eds Tache Y Wingate D (CRC Press, Boca Raton, Florida), pp 297\u2013305."},{"key":"2025121306303329000_42.6.845.2","unstructured":"Drossman DA Richter JE Talley NJ (1994) The functional gastrointestinal disorders. 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