{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:33:59Z","timestamp":1778675639408,"version":"3.51.4"},"reference-count":22,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,1,19]]},"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Fibroblast growth factor 5 (FGF-5) belongs to a group of mitogenic and angiogenic heparin binding growth factors but its potential role in chronic inflammatory conditions is not known.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To compare FGF-5 expression in the normal pancreas and in the pancreas of patients with chronic pancreatitis (CP) and to characterise FGF-5 expression and secretion in TAKA-1 cells, an immortalised Syrian hamster pancreatic duct cell line.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and results<\/jats:italic>\n                    \u2014Northern blotting revealed the presence of a 4.0 kb FGF-5 mRNA transcript in both normal and CP tissue samples. Densitometric analysis indicated that the transcript levels were increased by a factor of 1.44 in CP tissue samples compared with normal tissue samples (p=0.039). By immunohistochemisty and in situ hybridisation, FGF-5 was faintly expressed in ductal and islet cells in the normal pancreas. In contrast, in CP tissue samples, there was abundant expression of FGF-5 in ductal, acinar, and islet cells, as well as in periductal fibroblasts. FGF-5 was also expressed in TAKA-1 cells as determined by Northern blotting. By immunoblotting of heparin-sepharose precipitates, TAKA-1 cells were shown to secrete FGF-5 into the medium.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014Exocrine and stromal derived FGF-5 has the potential to participate in autocrine and paracrine pathways that may contribute to the pathobiology of chronic pancreatitis.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.1.134","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"134-139","source":"Crossref","is-referenced-by-count":21,"title":["Enhanced fibroblast growth factor 5 expression in stromal and exocrine elements of the pancreas in chronic pancreatitis"],"prefix":"10.1136","volume":"43","author":[{"given":"T","family":"Ishiwata","sequence":"first","affiliation":[{"name":"aDepartments of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, California, USA, \n\nbDepartment of General Surgery, University of Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kornmann","sequence":"additional","affiliation":[{"name":"aDepartments of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, California, USA, \n\nbDepartment of General Surgery, University of Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H G","family":"Beger","sequence":"additional","affiliation":[{"name":"aDepartments of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, California, USA, \n\nbDepartment of General Surgery, University of Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Korc","sequence":"additional","affiliation":[{"name":"aDepartments of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, California, 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