{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:28:44Z","timestamp":1791052124856,"version":"4.1.0"},"reference-count":47,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,2,4]]},"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014The efficacy of endoscopic biopsy surveillance of Barrett\u2019s oesophagus in reducing mortality from oesophageal cancer has not been confirmed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To investigate the impact of endoscopic biopsy surveillance on pathological stage and clinical outcome of Barrett\u2019s carcinoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014A clinicopathological comparison was made between patients who initially presented with oesophageal adenocarcinoma (n=54), and those in whom the cancer had been detected during surveillance of Barrett\u2019s oesophagus (n=16).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014The surveyed patients were known to have Barrett\u2019s oesophagus for a median period of 42 months (range 6\u2013144 months). Prior to the detection of adenocarcinoma or high grade dysplasia, 13 of 16 patients (81%) were previously found to have low grade dysplasia. Surgical pathology showed that surveyed patients had significantly earlier stages than non-surveyed patients (p=0.0001). Only one surveyed patient (6%) versus 34 non-surveyed patients (63%) had nodal involvement (p=0.0001). Two year survival was 85.9% for surveyed patients and 43.3% for non-surveyed patients (p=0.0029).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014The temporal course of histological progression in our surveyed patients supports the theory that adenocarcinoma in Barrett\u2019s oesophagus develops through stages of increasing severity of dysplasia. Endoscopic biopsy surveillance of Barrett\u2019s oesophagus permits detection of malignancy at an early and curable stage, thereby potentially reducing mortality from oesophageal adenocarcinoma.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.2.216","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"216-222","source":"Crossref","is-referenced-by-count":325,"title":["Impact of endoscopic biopsy surveillance of Barrett\u2019s oesophagus on pathological stage and clinical outcome of Barrett\u2019s carcinoma"],"prefix":"10.1136","volume":"43","author":[{"given":"J W","family":"van Sandick","sequence":"first","affiliation":[{"name":"aDepartment of Surgery, \n\nbDepartment of Gastroenterology, \n\ncDepartment of Pathology, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J B","family":"van Lanschot","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery, \n\nbDepartment of Gastroenterology, \n\ncDepartment of Pathology, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B W","family":"Kuiken","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery, \n\nbDepartment of Gastroenterology, \n\ncDepartment of Pathology, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G N J","family":"Tytgat","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery, \n\nbDepartment of Gastroenterology, \n\ncDepartment of Pathology, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G J A","family":"Offerhaus","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery, \n\nbDepartment of Gastroenterology, \n\ncDepartment of Pathology, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Obertop","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery, \n\nbDepartment of Gastroenterology, \n\ncDepartment of Pathology, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,8,1]]},"reference":[{"key":"2025121222215998000_43.2.216.1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0016-5085(87)90847-X","article-title":"Barrett\u2019s esophagus. 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