{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:18:24Z","timestamp":1779880704484,"version":"3.53.1"},"reference-count":50,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,2,4]]},"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbit model of severe acute pancreatitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Acute pancreatitis was induced by retrograde injection of 5% chenodeoxycholic acid into the pancreatic duct and duct ligation. Twenty rabbits were divided equally into two groups: acute pancreatitis controls received physiological saline and the treated group received WS-4, 30 minutes before induction of acute pancreatitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Pretreatment of animals with WS-4 resulted in significant down regulation of serum IL-8 and tumour necrosis factor \u03b1 (TNF-\u03b1) from three to six hours after induction of acute pancreatitis (p=0.011 and 0.047 for IL-8 and 0.033 and 0.022 for TNF-\u03b1, respectively). In addition, a significant reduction in the CD11b and CD18 positive cells and the amount of interstitial neutrophil infiltration in the lungs from WS-4 treated animals was seen. In contrast, WS-4 did not alter the amount of pancreatic necrosis and the serum concentrations of amylase, lipase, calcium, and glucose.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014WS-4 cannot change the amount of pancreatic necrosis induced by injection of 5% bile acid, but does reduce the acute lung injury, presumably through inhibition of circulating IL-8 and TNF-\u03b1, and CD11b\/CD18 in lung tissue. Therefore, a role of IL-8 in the progression of acute pancreatitis and the development of its systemic complications is suggested.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.2.232","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"232-239","source":"Crossref","is-referenced-by-count":102,"title":["A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits"],"prefix":"10.1136","volume":"43","author":[{"given":"M O","family":"Osman","sequence":"first","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J U","family":"Kristensen","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N O","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S B","family":"Lausten","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Deleuran","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Deleuran","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gesser","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Matsushima","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, \n\nbDepartment of Pathology, \n\ncDepartment of Rheumatology, \n\ndDepartment of Dermatology, \n\neDepartment of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C G","family":"Larsen","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery L, Aarhus University Hospital, Denmark, 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