{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:28:49Z","timestamp":1769498929736,"version":"3.49.0"},"reference-count":28,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,2,18]]},"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Routine coagulation tests do not necessarily reflect haemostasis in vivo in cirrhotic patients, particularly those who have bleeding varices. Thrombelastography (TEG) can provide a global assessment of haemostatic function from initial clot formation to clot dissolution.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    \u2014To evaluate TEG changes in cirrhotic patients with variceal bleeding and their association with early rebleeding.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients\/Methods<\/jats:italic>\n                    \u2014Twenty cirrhotic patients with active variceal bleeding had serial TEG and routine coagulation tests daily for seven days. The TEG variables before the day of rebleeding (n = 6) were compared with those of patients without rebleeding (n = 14).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Baseline characteristics of the rebleeding and non-rebleeding groups were comparable apart from a higher incidence of uncontrolled infection on the day of rebleeding in the rebleeding group (p = 0.007). The patients in the rebleeding group were more hypocoagulable before the day of rebleeding as shown by longer\n                    <jats:italic>r<\/jats:italic>\n                    (42\n                    <jats:italic>v<\/jats:italic>\n                    24 mm, p&lt;0.001) and\n                    <jats:italic>k<\/jats:italic>\n                    (48\n                    <jats:italic>v<\/jats:italic>\n                    13 mm, p&lt;0.001) and smaller\n                    <jats:italic>a<\/jats:italic>\n                    (12\n                    <jats:italic>v<\/jats:italic>\n                    38\u00b0, p&lt;0.001) compared with the mean of daily results of the non-rebleeding group. Routine coagulation tests, however, showed no significant differences between the two groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    \u2014The results of serial TEG measurements suggest that hypocoagulability may be associated with early rebleeding in cirrhotic patients.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.2.267","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"267-271","source":"Crossref","is-referenced-by-count":91,"title":["Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding"],"prefix":"10.1136","volume":"43","author":[{"given":"T N","family":"Chau","sequence":"first","affiliation":[{"name":"aDepartment of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK, \n\nbDepartment of Public Health, School of Medicine, Kyushu University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y W","family":"Chan","sequence":"additional","affiliation":[{"name":"aDepartment of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK, \n\nbDepartment of Public Health, School of Medicine, Kyushu University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Patch","sequence":"additional","affiliation":[{"name":"aDepartment of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK, \n\nbDepartment of Public Health, School of Medicine, Kyushu University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"aDepartment of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK, \n\nbDepartment of Public Health, School of Medicine, Kyushu University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Greenslade","sequence":"additional","affiliation":[{"name":"aDepartment of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK, \n\nbDepartment of Public Health, School of Medicine, Kyushu University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Burroughs","sequence":"additional","affiliation":[{"name":"aDepartment of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK, \n\nbDepartment of Public Health, School of Medicine, Kyushu University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,8,1]]},"reference":[{"key":"2025112108432378000_43.2.267.1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/hep.1840060631","article-title":"Pitfalls in studies of prophylactic therapy for variceal bleeding in cirrhotics.","volume":"6","author":"Burroughs","year":"1986","journal-title":"Hepatology"},{"key":"2025112108432378000_43.2.267.2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(85)91444-8","article-title":"Porphylactic endoscopic sclerotherapy of oesophageal varices. 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