{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:48:35Z","timestamp":1791103715014,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,4,8]]},"published-print":{"date-parts":[[1998,9,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014During the interdigestive state in humans, erythromycin 40 mg induces a premature activity front that starts in the stomach, while erythromycin 200 mg induces a prolonged period of enhanced antral contractile activity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To study the involvement of a cholinergic pathway in the motor effects of erythromycin using the muscarinic antagonist atropine and the neural 5-HT\n                    <jats:sub>1<\/jats:sub>\n                    receptor agonist sumatriptan.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014In 30 healthy volunteers, fasted antroduodenojejunal motor activity was studied by stationary manometry. Placebo (n=10), atropine (15 \u03bcg\/kg intravenous bolus plus 15 \u03bcg\/kg\/h over 30 minutes; n=10), or sumatriptan (6 mg subcutaneously; n=10) was administered, followed by infusion of erythromycin 40 mg or 200 mg.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014After placebo, erythromycin 40 mg induced a premature activity front with gastric onset after 19.1 (1.7) minutes in all volunteers. After atropine, erythromycin 40 mg failed to induce a premature activity front during a 60 minute period in all volunteers (p&lt;0.001), while sumatriptan prevented the induction of a premature activity front during a 60 minute period in all but one volunteer (p&lt;0.005). The number of antral contractions and their mean amplitude in the 60 minutes after erythromycin 200 mg did not differ significantly after atropine or sumatriptan versus placebo.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014The antral motor effects of erythromycin in humans are mediated via different pathways. The induction of a premature activity front is mediated through activation of an intrinsic cholinergic pathway, while the induction of enhanced antral contractile activity may be mediated via a pathway potentially involving activation of a muscular receptor.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.3.395","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"395-400","source":"Crossref","is-referenced-by-count":145,"title":["Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans"],"prefix":"10.1136","volume":"43","author":[{"given":"B","family":"Coulie","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,9,1]]},"reference":[{"key":"2025121312464224000_43.3.395.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004123221502"},{"key":"2025121312464224000_43.3.395.2","first-page":"1490","article-title":"Intravenous erythromycin dramatically accelerates gastric emptying in gastroparesis diabeticorum and normals and abolishes the emptying discrimination between solids and liquids.","volume":"31","author":"Urbain","year":"1990","journal-title":"J Nucl Med"},{"key":"2025121312464224000_43.3.395.3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91097-N"},{"key":"2025121312464224000_43.3.395.4","first-page":"G470","article-title":"Erythromycin is a motilin receptor agonist.","volume":"237","author":"Peeters","year":"1989","journal-title":"Am J Physiol"},{"key":"2025121312464224000_43.3.395.5","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91089-Z"},{"key":"2025121312464224000_43.3.395.6","first-page":"G418","article-title":"Gastrokinetic effects of erythromycin: myogenic and neurogenic mechanisms of action in rabbit stomach.","volume":"269","author":"Parkman","year":"1995","journal-title":"Am J Physiol"},{"key":"2025121312464224000_43.3.395.7","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(96)00053-8"},{"key":"2025121312464224000_43.3.395.8","first-page":"A490","article-title":"Erythromycin acts on presynaptic neurons to stimulate gastrointestinal motor activity [abstract]].","volume":"100","author":"Sarna","year":"1991","journal-title":"Gastroenterology"},{"key":"2025121312464224000_43.3.395.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02090212"},{"key":"2025121312464224000_43.3.395.10","first-page":"A547","article-title":"Erythromycin accelerates gastric and gallbladder emptying through a cholinergic mediated mechanism in humans [abstract]].","volume":"104","author":"Marzlo","year":"1993","journal-title":"Gastroenterology"},{"key":"2025121312464224000_43.3.395.11","doi-asserted-by":"crossref","unstructured":"Bruley des Varannes S, Parys V, Ropert A,et al. Erythromycin enhances fasting and postprandial proximal gastric tone in humans.Gastroenterology1995;109:32\u20139. .","DOI":"10.1016\/0016-5085(95)90266-X"},{"key":"2025121312464224000_43.3.395.12","first-page":"29","article-title":"Sumatriptan is an agonist at 5-HT1P receptors on myenteric neurons in the guinea-pig antrum [abstract]].","volume":"7","author":"Vanden Berghe","year":"1995","journal-title":"Neurogastroenterol Motil"},{"key":"2025121312464224000_43.3.395.13","first-page":"G386","article-title":"Blockade of 5-HT-mediated enteric slow EPSPs by BRL 24924: gastrokinetic effects.","volume":"257","author":"Mawe","year":"1989","journal-title":"Am J Physiol"},{"key":"2025121312464224000_43.3.395.14","first-page":"G902","article-title":"Sumatriptan, a selective 5HT1 receptor agonist, induces a lag phase for gastric emptying of liquids in humans.","volume":"272","author":"Coulie","year":"1997","journal-title":"Am J Physiol"},{"key":"2025121312464224000_43.3.395.15","doi-asserted-by":"crossref","first-page":"A696","DOI":"10.1016\/0016-5085(95)27097-3","article-title":"Sumatriptan, a 5-HT1 receptor agonist, causes a significant relxation of the gastric fundus in man [abstract]].","volume":"108","author":"Tack","year":"1995","journal-title":"Gastroenterology"},{"key":"2025121312464224000_43.3.395.16","first-page":"A715","article-title":"Motor patterns underlying the delay in gastric emptying during 5-HT1 receptor activation in man [abstract]].","volume":"112","author":"Coulie","year":"1997","journal-title":"Gastroenterology"},{"key":"2025121312464224000_43.3.395.17","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199243050-00010"},{"key":"2025121312464224000_43.3.395.18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108740"},{"key":"2025121312464224000_43.3.395.19","first-page":"289","article-title":"The 5-HT1 agonist sumatriptan induces a premature intestinal activity front in man [abstract]].","volume":"7","author":"Tack","year":"1995","journal-title":"Neurogastroenterol Motil"},{"key":"2025121312464224000_43.3.395.20","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991914"},{"key":"2025121312464224000_43.3.395.21","doi-asserted-by":"crossref","first-page":"A573","DOI":"10.1016\/0016-5085(95)26605-4","article-title":"Neural mediation of the motilin motor effect on the human antrum [abstract]].","volume":"108","author":"Boivin","year":"1995","journal-title":"Gastroenterology"},{"key":"2025121312464224000_43.3.395.22","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/0024-3205(84)90305-9","article-title":"The mechanism of motilin excitation of the canine small intestine.","volume":"34","author":"Fox","year":"1984","journal-title":"Life Sci"},{"key":"2025121312464224000_43.3.395.23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(88)90131-X"},{"key":"2025121312464224000_43.3.395.24","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90014-X"},{"key":"2025121312464224000_43.3.395.25","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(86)90084-4"},{"key":"2025121312464224000_43.3.395.26","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580991"},{"key":"2025121312464224000_43.3.395.27","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(88)90025-0"},{"key":"2025121312464224000_43.3.395.28","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0022-3565(25)22837-3","article-title":"EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum.","volume":"271","author":"Satoh","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"2025121312464224000_43.3.395.29","first-page":"291","article-title":"Evidence for an excitatory effect of motilin on enteric neurons in the rabbit antrum in vitro [abstract]].","volume":"7","author":"Van Assche","year":"1995","journal-title":"Neurogastroenterol Motil"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.43.3.395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:46:50Z","timestamp":1765658810000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.43.3.395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,9,1]]},"published-print":{"date-parts":[[1998,9,1]]}},"alternative-id":["10.1136\/gut.43.3.395"],"URL":"https:\/\/doi.org\/10.1136\/gut.43.3.395","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,1]]}}}