{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:16:49Z","timestamp":1765621009956,"version":"3.48.0"},"reference-count":44,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,3,23]]},"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Gastric mucosal surface hydrophobicity (GMSH) is an essential component of the mucosal defence system that is decreased by\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    and non-steroidal anti-inflammatory drugs (NSAIDs). Gastric ulcers occur predominantly in elderly subjects, and may thus reflect diminished mucosal resistance.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To investigate whether aging decreases GMSH.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients<\/jats:italic>\n                    \u2014One hundred and twenty patients without peptic ulcer disease were divided into three age groups: I (41 years or below); II (41\u201364 years); and III (65 years or above).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Biopsy specimens were taken from the antrum, corpus, and cardia for histology (Sydney system), urease testing for\n                    <jats:italic>H pylori<\/jats:italic>\n                    , and for contact angle measurement of GMSH with a goniometer. The presence of specific\n                    <jats:italic>H pylori<\/jats:italic>\n                    antibodies was checked by immunoblotting.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Fifty two patients (43%) were infected, and 68 were uninfected with\n                    <jats:italic>H pylori.<\/jats:italic>\n                    GMSH at all biopsy sites was lower in\n                    <jats:italic>H pylori<\/jats:italic>\n                    infected subjects (p=0.0001), but also decreased with age independently of infection status (p=0.0001). The most notable decrease in GMSH occurred between age groups I and II in those with, and between age groups II and III in those without,\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection. GMSH was greater in antral than in corpus mucosa in both infected (p=0.0001) and uninfected patients (p=0.0003).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014A physiological decrease in GMSH with aging may contribute to the risk of ulcer development in the elderly, and may act synergistically with\n                    <jats:italic>H pylori<\/jats:italic>\n                    and\/or NSAIDs on gastric mucosal defence.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.4.465","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"465-469","source":"Crossref","is-referenced-by-count":24,"title":["Age and\n                    <i>Helicobacter pylori<\/i>\n                    decrease gastric mucosal surface hydrophobicity independently"],"prefix":"10.1136","volume":"43","author":[{"given":"A","family":"Hackelsberger","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology, Hepatology, and Infectious Diseases, \n\nbDepartment of Pathology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Platzer","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Hepatology, and Infectious Diseases, \n\nbDepartment of Pathology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nilius","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Hepatology, and Infectious Diseases, \n\nbDepartment of Pathology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Schultze","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Hepatology, and Infectious Diseases, \n\nbDepartment of Pathology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Hepatology, and Infectious Diseases, \n\nbDepartment of Pathology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Dominguez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Hepatology, and Infectious Diseases, \n\nbDepartment of Pathology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Malfertheiner","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Hepatology, and Infectious Diseases, \n\nbDepartment of Pathology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"2025121302124683000_43.4.465.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520010077036"},{"key":"2025121302124683000_43.4.465.2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0016-5085(89)80061-7","article-title":"Towards an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug 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