{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:03:21Z","timestamp":1791205401529,"version":"4.1.0"},"reference-count":26,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,3,4]]},"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014It has been proposed that a pathogenic effect of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is a weakening of the protective mucus barrier; however, this remains controversial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To clarify the effects of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection on the mucus gel barrier in vivo.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Mucus gel polymeric structure and the thickness of the adherent mucus barrier were measured in endoscopic biopsy samples in subjects with and without\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014There was a significant 18% reduction in the proportion of polymeric gel forming mucin in the adherent mucus layer in\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive compared with negative subjects. There was no change in the adherent mucus thickness between\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive and negative subjects without gastric atrophy (mean (SD): 104 (26) \u03bcm, 106 (30) \u03bcm respectively). There was however a significant reduction in mucus thickness in those\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive subjects with underlying gastric atrophy (84 (13) \u03bcm, p=0.03) compared with those without atrophy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014A partial breakdown in gel forming structure of the gastric mucus barrier does occur in\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection per se but this is insufficient to cause a collapse of the mucus barrier\n                    <jats:italic>.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1136\/gut.43.4.470","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"470-475","source":"Crossref","is-referenced-by-count":40,"title":["<i>Helicobacter pylori<\/i>\n  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Physiological Sciences, \n\nbDepartment of Medicine, University of Newcastle-upon- Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pearson","sequence":"additional","affiliation":[{"name":"aDepartment of Physiological Sciences, \n\nbDepartment of Medicine, University of Newcastle-upon- Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O F W","family":"James","sequence":"additional","affiliation":[{"name":"aDepartment of Physiological Sciences, \n\nbDepartment of Medicine, University of Newcastle-upon- Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Allen","sequence":"additional","affiliation":[{"name":"aDepartment of Physiological Sciences, \n\nbDepartment of Medicine, University of Newcastle-upon- Tyne, 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